HitPredict

Interactor 1: FMR1 (Q06787)
Fragile X messenger ribonucleoprotein 1 (Fragile X messenger ribonucleoprotein) (FMRP) (Protein FMR-1)
Gene: FMR1

Interactor 2: PRC2B (Q5JSZ5)
Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B)
Gene: PRRC2B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29395067
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 632 Hs			1 2229
+	Mm
		729533 FMR1_MOUSE (1-632): 0: 1063: 93.99		PRC2A_MOUSE (1-2188): 2.51e-101: 366: 22.76
+	Mm
		729531 FMR1_MOUSE (1-632): 0: 1063: 93.99		PRC2B_MOUSE (1-1460): 6.92e-75: 279: 48.22
+	Hs
		311804 FMR1_HUMAN (1-632): 0: 1106: 100.00		TACC2_HUMAN (220-2228): 4.35e-33: 143: 9.07
+	Hs
		989216 FMR1_HUMAN (1-632): 0: 1106: 100.00		PRC2C_HUMAN (85-2229): 5.01e-29: 130: 8.12
+	Hs
		843719 FXR1_HUMAN (1-334): 0: 604: 73.95		PRC2B_HUMAN (1-2229): 0: 619: 100.00
+	Mm
		729509 FMR1_MOUSE (1-632): 0: 1063: 93.99		NIPBL_MOUSE (85-1137): 1.28e-34: 148: 10.73
+	Hs
		820894 FMR1_HUMAN (1-632): 0: 1106: 100.00		PRC2A_HUMAN (971-2229): 8.27e-11: 70.1: 8.24
+	Mm
		729462 FMR1_MOUSE (1-632): 0: 1063: 93.99		PRC2C_MOUSE (115-1260): 2.73e-14: 81.6: 7.40
+	Mm
		1186751 Q8BPK8_MOUSE (1-357): 0: 688: 97.76		PRC2A_MOUSE (1-2188): 2.51e-101: 366: 22.76
+	Mm
		1186627 Q8BPK8_MOUSE (1-357): 0: 688: 97.76		PRC2B_MOUSE (1-1460): 6.92e-75: 279: 48.22
+	Mm
		1142853 FXR1_MOUSE (1-334): 0: 596: 73.65		PRC2A_MOUSE (1-2188): 2.51e-101: 366: 22.76
+	Mm
		1142852 FXR1_MOUSE (1-334): 0: 596: 73.65		PRC2B_MOUSE (1-1460): 6.92e-75: 279: 48.22
+	Mm
		1154098 Q8BPK8_MOUSE (1-357): 0: 688: 97.76		NIPBL_MOUSE (85-1137): 1.28e-34: 148: 10.73
+	Mm
		1111989 Q8BPK8_MOUSE (1-357): 0: 688: 97.76		PRC2C_MOUSE (115-1260): 2.73e-14: 81.6: 7.40
+	Hs
		311796 FXR1_HUMAN (1-334): 0: 604: 73.95		TACC2_HUMAN (220-2228): 4.35e-33: 143: 9.07
+	Hs
		843980 FXR1_HUMAN (1-334): 0: 604: 73.95		PRC2C_HUMAN (85-2229): 5.01e-29: 130: 8.12
+	Hs
		843666 FXR1_HUMAN (1-334): 0: 604: 73.95		EIF3A_HUMAN (962-1409): 3.68e-26: 120: 14.63
+	Mm
		1111986 FXR1_MOUSE (1-334): 0: 596: 73.65		PRC2C_MOUSE (115-1260): 2.73e-14: 81.6: 7.40
+	Hs
		820851 FXR1_HUMAN (1-334): 0: 604: 73.95		PRC2A_HUMAN (971-2229): 8.27e-11: 70.1: 8.24
+	Hs
		820852 FXR2_HUMAN (268-525): 3.17e-50: 186: 30.56		PRC2A_HUMAN (971-2229): 8.27e-11: 70.1: 8.24