Protein: NKX21
Homeobox protein Nkx-2.1 (Homeobox protein NK-2 homolog A) (Thyroid nuclear factor 1) (Thyroid transcription factor 1) (TTF-1) (Thyroid-specific enhancer-binding protein) (T/EBP)

Gene: NKX21, NKX2-1
Organism: Homo sapiens
Interactions: 174
UniProt ID: P43699

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

799069

FOXA1
Hepatocyte nuclear factor 3-alpha

3

20

Small-scale

0.669

High

799133

CBP
CREB-binding protein

3

20

Small-scale

0.650

High

799108

NCOA1
Nuclear receptor coactivator 1

2

15

Small-scale

0.619

High

447229

HXB5
Homeobox protein Hox-B5

1

20

Small-scale

0.618

High

799056

NKX21
Homeobox protein Nkx-2.1

1

18

High-throughput

0.618

High

799109

ZFHX3
Zinc finger homeobox protein 3

1

17

High-throughput

0.618

High

799159

SATB2
DNA-binding protein SATB2

1

12

High-throughput

0.618

High

799166

NCOA3
Nuclear receptor coactivator 3

2

20

Small-scale

0.594

High

799089

PAX8
Paired box protein Pax-8

1

18

Small-scale

0.561

High

799151

TAP26
Thyroid transcription factor 1-associated protein 26

1

0

Small-scale

0.506

High

653509

CALR
Calreticulin

1

0

Small-scale

0.504

High

487918

RARA
Retinoic acid receptor alpha

1

13

Small-scale

0.481

High

799107

NCOA2
Nuclear receptor coactivator 2

1

20

Small-scale

0.481

High

799149

HIPK2
Homeodomain-interacting protein kinase 2

1

4

Small-scale

0.481

High

799114

CAVN1
Caveolae-associated protein 1

1

0

Small-scale

0.480

High

134844

IMA3
Importin subunit alpha-3

1

2

High-throughput

0.479

High

151479

CHD2
Chromodomain-helicase-DNA-binding protein 2

1

17

High-throughput

0.479

High

229336

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

High-throughput

0.479

High

232033

KDM1A
Lysine-specific histone demethylase 1A

1

3

High-throughput

0.479

High

260791

H2AY
Core histone macro-H2A.1

1

1

High-throughput

0.479

High

266931

SRS10
Serine/arginine-rich splicing factor 10

1

1

High-throughput

0.479

High

295957

MTA2
Metastasis-associated protein MTA2

1

18

High-throughput

0.479

High

337386

ABL1
Tyrosine-protein kinase ABL1

1

7

High-throughput

0.479

High

359312

K1C14
Keratin, type I cytoskeletal 14

1

2

High-throughput

0.479

High

359737

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

3

High-throughput

0.479

High

412077

FYN
Tyrosine-protein kinase Fyn

1

7

High-throughput

0.479

High

443146

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

455188

PARP1
Poly [ADP-ribose] polymerase 1

1

9

High-throughput

0.479

High

508387

TOP1
DNA topoisomerase 1

1

5

High-throughput

0.479

High

518604

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.479

High

522846

SRC
Proto-oncogene tyrosine-protein kinase Src

1

7

High-throughput

0.479

High

523574

XRCC6
X-ray repair cross-complementing protein 6

1

7

High-throughput

0.479

High

524827

XRCC5
X-ray repair cross-complementing protein 5

1

7

High-throughput

0.479

High

547740

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

12

High-throughput

0.479

High

548231

FOSL1
Fos-related antigen 1

1

13

High-throughput

0.479

High

552157

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

557634

NCK1
SH2/SH3 adapter protein NCK1

1

11

High-throughput

0.479

High

566733

JUNB
Transcription factor JunB

1

14

High-throughput

0.479

High

568250

ATF7
Cyclic AMP-dependent transcription factor ATF-7

1

13

High-throughput

0.479

High

569345

CEBPB
CCAAT/enhancer-binding protein beta

1

11

High-throughput

0.479

High

572887

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

579669

XRCC1
DNA repair protein XRCC1

1

1

High-throughput

0.479

High

595128

LMNB1
Lamin-B1

1

3

High-throughput

0.479

High

613368

SFPQ
Splicing factor, proline- and glutamine-rich

1

6

High-throughput

0.479

High

643444

PTBP1
Polypyrimidine tract-binding protein 1

1

2

High-throughput

0.479

High

650593

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

658468

TEAD1
Transcriptional enhancer factor TEF-1

1

1

High-throughput

0.479

High

708829

MCM7
DNA replication licensing factor MCM7

1

2

High-throughput

0.479

High

718590

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

719896

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

721939

RFC4
Replication factor C subunit 4

1

4

High-throughput

0.479

High

722076

RFC2
Replication factor C subunit 2

1

4

High-throughput

0.479

High

722184

RFC1
Replication factor C subunit 1

1

7

High-throughput

0.479

High

724050

K1C9
Keratin, type I cytoskeletal 9

1

3

High-throughput

0.479

High

726639

FUS
RNA-binding protein FUS

1

4

High-throughput

0.479

High

740115

NUP62
Nuclear pore glycoprotein p62

1

10

High-throughput

0.479

High

745087

RBMX
RNA-binding motif protein, X chromosome

1

2

High-throughput

0.479

High

777824

RFC5
Replication factor C subunit 5

1

4

High-throughput

0.479

High

777956

RFC3
Replication factor C subunit 3

1

4

High-throughput

0.479

High

781604

ETV6
Transcription factor ETV6

1

20

High-throughput

0.479

High

785737

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.479

High

799057

RAGP1
Ran GTPase-activating protein 1

1

2

High-throughput

0.479

High

799058

CRK
Adapter molecule crk

1

7

High-throughput

0.479

High

799060

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

799061

DNLI3
DNA ligase 3

1

3

High-throughput

0.479

High

799062

DNLI4
DNA ligase 4

1

3

High-throughput

0.479

High

799063

EMD
Emerin

1

4

High-throughput

0.479

High

799064

MECP2
Methyl-CpG-binding protein 2

1

4

High-throughput

0.479

High

799065

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

3

High-throughput

0.479

High

799066

NUP98
Nuclear pore complex protein Nup98-Nup96

1

14

High-throughput

0.479

High

799067

XPO2
Exportin-2

1

1

High-throughput

0.479

High

799070

SEC13
Protein SEC13 homolog

1

5

High-throughput

0.479

High

799072

H4
Histone H4

1

3

High-throughput

0.479

High

799073

RAN
GTP-binding nuclear protein Ran

1

1

High-throughput

0.479

High

799074

GRB2
Growth factor receptor-bound protein 2

1

13

High-throughput

0.479

High

799075

TRA2B
Transformer-2 protein homolog beta

1

2

High-throughput

0.479

High

799077

H31
Histone H3.1

1

3

High-throughput

0.479

High

799079

RAE1L
mRNA export factor RAE1

1

11

High-throughput

0.479

High

799080

PRKDC
DNA-dependent protein kinase catalytic subunit

1

2

High-throughput

0.479

High

799082

H33
Histone H3.3

1

3

High-throughput

0.479

High

799083

TFAM
Transcription factor A, mitochondrial

1

20

High-throughput

0.479

High

799085

RUNX1
Runt-related transcription factor 1

1

1

High-throughput

0.479

High

799086

TF65
Transcription factor p65

1

7

Small-scale

0.479

High

799087

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

6

High-throughput

0.479

High

799088

PSME1
Proteasome activator complex subunit 1

1

2

High-throughput

0.479

High

799090

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.479

High

799091

RBBP4
Histone-binding protein RBBP4

1

14

High-throughput

0.479

High

799093

TFCP2
Alpha-globin transcription factor CP2

1

2

High-throughput

0.479

High

799094

ILF2
Interleukin enhancer-binding factor 2

1

2

High-throughput

0.479

High

799095

TIF1B
Transcription intermediary factor 1-beta

1

7

High-throughput

0.479

High

799096

CTBP1
C-terminal-binding protein 1

1

2

High-throughput

0.479

High

799098

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

8

High-throughput

0.479

High

799099

HDAC1
Histone deacetylase 1

1

11

High-throughput

0.479

High

799101

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

7

High-throughput

0.479

High

799102

MDC1
Mediator of DNA damage checkpoint protein 1

1

20

High-throughput

0.479

High

799104

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

14

High-throughput

0.479

High

799105

IMB1
Importin subunit beta-1

1

1

High-throughput

0.479

High

799106

NONO
Non-POU domain-containing octamer-binding protein

1

7

High-throughput

0.479

High

799110

DDB1
DNA damage-binding protein 1

1

1

High-throughput

0.479

High

799111

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.479

High

799115

H2AV
Histone H2A.V

1

2

High-throughput

0.479

High

799116

APTX
Aprataxin

1

3

High-throughput

0.479

High

799117

I2BP2
Interferon regulatory factor 2-binding protein 2

1

5

High-throughput

0.479

High

799118

THOC4
THO complex subunit 4

1

6

High-throughput

0.479

High

799119

I2BP1
Interferon regulatory factor 2-binding protein 1

1

5

High-throughput

0.479

High

799120

VRK3
Serine/threonine-protein kinase VRK3

1

2

High-throughput

0.479

High

799122

CGAS
Cyclic GMP-AMP synthase

1

2

High-throughput

0.479

High

799125

NUP43
Nucleoporin Nup43

1

8

High-throughput

0.479

High

799126

NUP37
Nucleoporin Nup37

1

11

High-throughput

0.479

High

799127

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

799129

ZN384
Zinc finger protein 384

1

5

High-throughput

0.479

High

799131

JDP2
Jun dimerization protein 2

1

10

High-throughput

0.479

High

799134

RBP56
TATA-binding protein-associated factor 2N

1

5

High-throughput

0.479

High

799137

RBM14
RNA-binding protein 14

1

2

High-throughput

0.479

High

799139

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

2

High-throughput

0.479

High

799141

OVOL2
Transcription factor Ovo-like 2

1

5

High-throughput

0.479

High

799143

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

4

High-throughput

0.479

High

799146

PDIP3
Polymerase delta-interacting protein 3

1

6

High-throughput

0.479

High

799147

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

11

High-throughput

0.479

High

799148

I2BPL
Probable E3 ubiquitin-protein ligase IRF2BPL

1

14

High-throughput

0.479

High

799150

TF7L2
Transcription factor 7-like 2

1

20

High-throughput

0.479

High

799152

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

17

High-throughput

0.479

High

799153

NXF1
Nuclear RNA export factor 1

1

1

High-throughput

0.479

High

799154

PARP2
Poly [ADP-ribose] polymerase 2

1

6

High-throughput

0.479

High

799155

TCF20
Transcription factor 20

1

17

High-throughput

0.479

High

799156

PUF60
Poly(U)-binding-splicing factor PUF60

1

3

High-throughput

0.479

High

799157

RCOR1
REST corepressor 1

1

20

High-throughput

0.479

High

799158

MAFF
Transcription factor MafF

1

5

High-throughput

0.479

High

799160

RTRAF
RNA transcription, translation and transport factor protein

1

1

High-throughput

0.479

High

799161

RUVB2
RuvB-like 2

1

1

High-throughput

0.479

High

799162

FOXA2
Hepatocyte nuclear factor 3-beta

1

16

Small-scale

0.479

High

799163

RUVB1
RuvB-like 1

1

1

High-throughput

0.479

High

799165

TR150
Thyroid hormone receptor-associated protein 3

1

6

High-throughput

0.479

High

214876

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.458

High

268418

BAF
Barrier-to-autointegration factor

1

0

High-throughput

0.458

High

380577

K2C1
Keratin, type II cytoskeletal 1

1

0

High-throughput

0.458

High

381843

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

508860

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.458

High

517122

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

564825

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.458

High

578388

RCC1
Regulator of chromosome condensation

1

0

High-throughput

0.458

High

799059

ATPO
ATP synthase subunit O, mitochondrial

1

0

High-throughput

0.458

High

799068

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

799076

UBC9
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.458

High

799097

XRCC4
DNA repair protein XRCC4

1

0

High-throughput

0.458

High

799100

PEBB
Core-binding factor subunit beta

1

0

High-throughput

0.458

High

799103

MVP
Major vault protein

1

0

High-throughput

0.458

High

799123

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

799124

LEMD2
LEM domain-containing protein 2

1

0

High-throughput

0.458

High

799140

NUP88
Nuclear pore complex protein Nup88

1

0

High-throughput

0.458

High

799145

NUP85
Nuclear pore complex protein Nup85

1

0

High-throughput

0.458

High

799081

SMAD3
Mothers against decapentaplegic homolog 3

1

9

Small-scale

0.457

High

770730

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.437

High

799078

TCPB
T-complex protein 1 subunit beta

1

1

High-throughput

0.437

High

799084

S25A3
Solute carrier family 25 member 3

1

1

High-throughput

0.437

High

799130

NU133
Nuclear pore complex protein Nup133

1

1

High-throughput

0.437

High

799132

NU205
Nuclear pore complex protein Nup205

1

1

High-throughput

0.437

High

799135

SEH1
Nucleoporin SEH1

1

5

High-throughput

0.437

High

799136

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

1

High-throughput

0.437

High

799144

NUP58
Nucleoporin p58/p45

1

2

High-throughput

0.437

High

799164

AMOL2
Angiomotin-like protein 2

1

2

High-throughput

0.437

High

48287

ESYT2
Extended synaptotagmin-2

1

0

High-throughput

0.249

Low

273719

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.249

Low

335065

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.249

Low

580621

ML12A
Myosin regulatory light chain 12A

1

0

High-throughput

0.249

Low

799071

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.249

Low

799092

NU160
Nuclear pore complex protein Nup160

1

0

High-throughput

0.249

Low

799112

NU188
Nucleoporin NUP188

1

0

High-throughput

0.249

Low

799113

TM214
Transmembrane protein 214

1

0

High-throughput

0.249

Low

799121

NUP93
Nuclear pore complex protein Nup93

1

0

High-throughput

0.249

Low

799128

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.249

Low

799138

TM209
Transmembrane protein 209

1

0

High-throughput

0.249

Low

799142

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024