HitPredict

Interactor 1: STX10 (O60499)
Syntaxin-10 (Syn10)
Gene: STX10

Interactor 2: VAMP4 (O75379)
Vesicle-associated membrane protein 4 (VAMP-4)
Gene: VAMP4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	28514442, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin
Common GO terms	GO:0000139 - Golgi membrane GO:0005802 - trans-Golgi network GO:0031201 - SNARE complex GO:0032588 - trans-Golgi network membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 249 Hs			1 141
+	Hs
		212689 STX6_HUMAN (1-233): 6.56e-59: 188: 61.09		VAMP4_HUMAN (1-120): 4.03e-40: 132: 100.00
+	Hs
		235174 STX10_HUMAN (1-233): 1.52e-69: 215: 100.00		VAMP3_HUMAN (47-119): 2.22e-26: 96.7: 41.10
+	Hs
		212772 STX6_HUMAN (1-233): 6.56e-59: 188: 61.09		VAMP7_HUMAN (15-139): 2.43e-33: 118: 27.20
+	Rn
		1144363 STX6_RAT (1-234): 2.54e-61: 195: 61.67		VAMP1_RAT (32-125): 5.09e-29: 103: 31.92
+	Hs
		235133 STX10_HUMAN (1-233): 1.52e-69: 215: 100.00		VAMP5_HUMAN (52-118): 5.78e-18: 75.8: 31.34
+	Rn
		1144365 STX6_RAT (1-234): 2.54e-61: 195: 61.67		VAMP8_RAT (44-116): 5.41e-24: 90.5: 30.14
+	Hs
		212844 STX6_HUMAN (1-233): 6.56e-59: 188: 61.09		VAMP3_HUMAN (47-119): 2.22e-26: 96.7: 41.10
+	Dm
		577224 Q7JRF1_DROME (1-249): 1.2e-51: 172: 31.23		SYB_DROME (24-135): 9.5e-32: 112: 26.79
+	Hs
		212790 STX6_HUMAN (1-233): 6.56e-59: 188: 61.09		VAMP2_HUMAN (46-122): 9.98e-26: 95.5: 35.07
+	Hs
		212988 STX6_HUMAN (1-233): 6.56e-59: 188: 61.09		VAMP8_HUMAN (41-120): 1.87e-25: 94.3: 27.50
+	Hs
		261740 STX8_HUMAN (3-230): 5.49e-38: 134: 16.52		VAMP4_HUMAN (1-120): 4.03e-40: 132: 100.00
+	Hs
		212700 STX6_HUMAN (1-233): 6.56e-59: 188: 61.09		VAMP5_HUMAN (52-118): 5.78e-18: 75.8: 31.34
+	Hs
		850607 STX8_HUMAN (3-230): 5.49e-38: 134: 16.52		VAMP7_HUMAN (15-139): 2.43e-33: 118: 27.20
+	Dm
		1178135 Q9VV76_DROME (5-235): 9.81e-35: 126: 14.72		Q7JYX5_DROME (15-138): 4.76e-36: 125: 27.42
+	Dm
		577257 Q9VV76_DROME (5-235): 9.81e-35: 126: 14.72		SYB_DROME (24-135): 9.5e-32: 112: 26.79
+	Hs
		1079469 STX8_HUMAN (3-230): 5.49e-38: 134: 16.52		VAMP3_HUMAN (47-119): 2.22e-26: 96.7: 41.10
+	Hs
		926267 STX8_HUMAN (3-230): 5.49e-38: 134: 16.52		VAMP2_HUMAN (46-122): 9.98e-26: 95.5: 35.07
+	Hs
		1313466 STX8_HUMAN (3-230): 5.49e-38: 134: 16.52		VAMP8_HUMAN (41-120): 1.87e-25: 94.3: 27.50
+	Sc
		605870 TLG1_YEAST (2-232): 9.05e-31: 115: 19.05		SEC22_YEAST (23-133): 3.08e-25: 97: 17.12
+	Hs
		306889 STX8_HUMAN (3-230): 5.49e-38: 134: 16.52		VAMP5_HUMAN (52-118): 5.78e-18: 75.8: 31.34