Protein: ESF1
Pre-rRNA-processing protein ESF1 (18S rRNA factor 1)

Gene: ESF1
Organism: Saccharomyces cerevisiae S288C
Interactions: 181
UniProt ID: Q06344

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0006364 - rRNA processing
GO:0030490 - maturation of SSU-rRNA

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

923257

ESF2
Pre-rRNA-processing protein ESF2

6

1

Small-scale

0.736

High

632746

DBP4
ATP-dependent RNA helicase HCA4

4

3

High-throughput

0.705

High

678466

PWP2
Periodic tryptophan protein 2

3

1

High-throughput

0.662

High

1054898

UTP4
U3 small nucleolar RNA-associated protein 4

3

1

High-throughput

0.654

High

844623

UTP10
U3 small nucleolar RNA-associated protein 10

4

0

High-throughput

0.653

High

918830

UTP22
U3 small nucleolar RNA-associated protein 22

3

0

Small-scale

0.643

High

871061

NOL10
Ribosome biogenesis protein ENP2

3

0

High-throughput

0.634

High

1054897

BFR2
Protein BFR2

3

0

High-throughput

0.634

High

525235

HSP71
Heat shock protein SSA1

3

1

High-throughput

0.633

High

586028

CSK21
Casein kinase II subunit alpha

2

2

High-throughput

0.633

High

802772

RRP3
ATP-dependent rRNA helicase RRP3

2

3

High-throughput

0.628

High

1054909

YRA1
RNA annealing protein YRA1

2

1

High-throughput

0.621

High

924638

NAT10
RNA cytidine acetyltransferase

2

1

High-throughput

0.614

High

677575

KRR1
KRR1 small subunit processome component

3

0

Small-scale

0.613

High

798320

ENP1
Essential nuclear protein 1

3

0

High-throughput

0.613

High

818347

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

2

1

High-throughput

0.611

High

1054917

NOP58
Nucleolar protein 58

2

2

High-throughput

0.611

High

585384

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

1

Small-scale

0.601

High

700297

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

2

1

High-throughput

0.601

High

823391

UTP18
U3 small nucleolar RNA-associated protein 18

2

0

High-throughput

0.588

High

1036415

UTP6
U3 small nucleolar RNA-associated protein 6

2

0

High-throughput

0.588

High

1054894

ESF1
Pre-rRNA-processing protein ESF1

2

0

High-throughput

0.588

High

1054908

SAS10
Something about silencing protein 10

2

0

High-throughput

0.588

High

806579

UTP9
U3 small nucleolar RNA-associated protein 9

2

0

High-throughput

0.585

High

1050169

RRP5
rRNA biogenesis protein RRP5

2

0

High-throughput

0.585

High

1053516

UTP21
U3 small nucleolar RNA-associated protein 21

2

2

Small-scale

0.584

High

751491

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

2

0

High-throughput

0.576

High

1039857

UTP17
NET1-associated nuclear protein 1

2

3

High-throughput

0.571

High

674848

RS2
Small ribosomal subunit protein uS5

2

0

Small-scale

0.559

High

826855

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.559

High

1046797

UTP14
U3 small nucleolar RNA-associated protein 14

2

0

High-throughput

0.559

High

1054896

NOC4
Nucleolar complex protein 4

2

0

High-throughput

0.559

High

427453

RLA0
Large ribosomal subunit protein uL10

2

2

Small-scale

0.558

High

779163

DHR2
Probable ATP-dependent RNA helicase DHR2

1

1

High-throughput

0.541

High

1043289

HAS1
ATP-dependent RNA helicase HAS1

1

4

High-throughput

0.541

High

381276

H2B1
Histone H2B.1

1

2

High-throughput

0.536

High

584276

MS116
ATP-dependent RNA helicase MSS116, mitochondrial

1

4

High-throughput

0.536

High

623019

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.536

High

851022

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.536

High

1054900

NOP12
Nucleolar protein 12

1

1

High-throughput

0.536

High

513232

RS8A
Small ribosomal subunit protein eS8A

2

1

High-throughput

0.533

High

752763

HSP78
Heat shock protein 78, mitochondrial

2

1

High-throughput

0.521

High

1053782

SGD1
Suppressor of glycerol defect protein 1

1

0

High-throughput

0.518

High

676530

PUT3
Proline utilization trans-activator

1

1

High-throughput

0.515

High

454003

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.513

High

531897

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.513

High

722277

XPO1
Exportin-1

1

0

High-throughput

0.513

High

751988

LHP1
La protein homolog

1

0

High-throughput

0.513

High

782454

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.513

High

518135

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.500

High

811696

CAT8
Regulatory protein CAT8

1

0

High-throughput

0.493

High

1054904

RRS1
Regulator of ribosome biosynthesis

1

0

High-throughput

0.493

High

1054907

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.493

High

1054912

GIN4
Serine/threonine-protein kinase GIN4

1

0

High-throughput

0.493

High

403663

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.479

High

645541

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.479

High

512158

RS4A
Small ribosomal subunit protein eS4A

1

2

High-throughput

0.479

High

692630

NSR1
Nuclear localization sequence-binding protein

1

1

Small-scale

0.479

High

802907

DBP8
ATP-dependent RNA helicase DBP8

1

3

High-throughput

0.479

High

808313

RRP8
25S rRNA

1

1

High-throughput

0.479

High

827616

RLP7
Ribosome biogenesis protein RLP7

1

1

Small-scale

0.479

High

1045109

UTP5
U3 small nucleolar RNA-associated protein 5

1

1

High-throughput

0.479

High

1053113

UTP13
U3 small nucleolar RNA-associated protein 13

1

3

High-throughput

0.479

High

1053607

MRD1
Multiple RNA-binding domain-containing protein 1

1

2

High-throughput

0.479

High

1054911

UTP12
U3 small nucleolar RNA-associated protein 12

1

2

High-throughput

0.479

High

410349

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

433861

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

435375

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.458

High

436183

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

436525

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

442122

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

448337

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.458

High

455275

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

570151

RL3
Large ribosomal subunit protein uL3

1

0

Small-scale

0.458

High

672954

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

673234

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.458

High

680083

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

689675

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

694649

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.458

High

708253

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

735177

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

754339

DCA13
Protein SOF1

1

0

High-throughput

0.458

High

1054540

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.458

High

758412

UTP11
U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

778544

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

782108

RL1D1
Ribosome biogenesis protein UTP30

1

0

High-throughput

0.458

High

792261

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.458

High

792964

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

808915

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

817638

UTP7
U3 small nucleolar RNA-associated protein 7

1

0

High-throughput

0.458

High

825086

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

825565

UTP25
U3 small nucleolar RNA-associated protein 25

1

0

High-throughput

0.458

High

826215

FAF1
Protein FAF1

1

0

High-throughput

0.458

High

852609

ROK1
ATP-dependent RNA helicase ROK1

1

0

High-throughput

0.458

High

864966

NOP9
Nucleolar protein 9

1

0

Small-scale

0.458

High

865178

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

0

High-throughput

0.458

High

919177

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

High-throughput

0.458

High

925077

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

925202

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

0

High-throughput

0.458

High

1033578

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

1044764

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

1046041

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

1046257

UTP15
U3 small nucleolar RNA-associated protein 15

1

0

High-throughput

0.458

High

1046476

BUD22
Bud site selection protein 22

1

0

High-throughput

0.458

High

1046519

PUF6
Pumilio homology domain family member 6

1

0

Small-scale

0.458

High

1051163

FCF1
rRNA-processing protein FCF1

1

0

High-throughput

0.458

High

1051614

HRQ1
ATP-dependent helicase HRQ1

1

0

Small-scale

0.458

High

1053970

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

1054895

RRP9
Ribosomal RNA-processing protein 9

1

0

High-throughput

0.458

High

1054899

RCL1
rRNA processing protein RCL1

1

0

High-throughput

0.458

High

1054902

SGO1
Shugoshin

1

0

High-throughput

0.458

High

1054903

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.458

High

1054905

BMS1
Ribosome biogenesis protein BMS1

1

0

High-throughput

0.458

High

1054906

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.458

High

1054916

RRP36
rRNA biogenesis protein RRP36

1

0

High-throughput

0.458

High

1054918

EFG1P
rRNA-processing protein EFG1

1

0

High-throughput

0.458

High

1054919

NOP14
Nucleolar complex protein 14

1

0

High-throughput

0.458

High

419514

H2A1
Histone H2A.1

1

2

High-throughput

0.445

High

419883

H2A2
Histone H2A.2

1

2

High-throughput

0.445

High

527746

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

546377

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

727330

HS104
Heat shock protein 104

1

1

High-throughput

0.445

High

742460

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

819869

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

963735

H3
Histone H3

1

2

High-throughput

0.445

High

1054910

RL7B
Large ribosomal subunit protein uL30B

1

1

High-throughput

0.445

High

1054915

NOP56
Nucleolar protein 56

1

2

High-throughput

0.445

High

504427

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

513912

RS11B
Small ribosomal subunit protein uS17B

1

2

High-throughput

0.437

High

747589

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

785978

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.437

High

382364

H4
Histone H4

1

0

High-throughput

0.426

High

590729

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

684850

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

776653

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.426

High

816559

SNU13
13 kDa ribonucleoprotein-associated protein

1

0

High-throughput

0.426

High

1054901

NOP8
60S ribosome subunit biogenesis protein NOP8

1

0

High-throughput

0.426

High

1054913

BMT6
25S rRNA

1

0

High-throughput

0.426

High

812679

LAA1
AP-1 accessory protein LAA1

2

0

High-throughput

0.318

High

810769

TCPB
T-complex protein 1 subunit beta

2

0

High-throughput

0.307

High

580105

HSC82
ATP-dependent molecular chaperone HSC82

2

0

High-throughput

0.298

High

420989

PMA1
Plasma membrane ATPase 1

1

0

High-throughput

0.279

Low

753597

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.279

Low

893232

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.279

Low

923130

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.279

Low

550696

SIR4
Regulatory protein SIR4

1

0

High-throughput

0.269

Low

575524

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.269

Low

713238

SEC65
Signal recognition particle subunit SEC65

1

0

High-throughput

0.269

Low

814280

RV167
Reduced viability upon starvation protein 167

1

0

High-throughput

0.269

Low

1054914

PAA1
Polyamine N-acetyltransferase 1

1

0

High-throughput

0.269

Low

416480

HXKA
Hexokinase-1

1

0

High-throughput

0.261

Low

678918

YCX7
Putative uncharacterized protein YCR087W

1

0

High-throughput

0.261

Low

1044248

YD102
Uncharacterized protein YDR102C

1

0

High-throughput

0.261

Low

383905

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

433298

RL17A
Large ribosomal subunit protein uL22A

1

0

High-throughput

0.249

Low

482095

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

0

Small-scale

0.249

Low

514847

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

672722

BPH1
Beige protein homolog 1

1

0

High-throughput

0.249

Low

802399

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

835894

RL10
Large ribosomal subunit protein uL16

1

0

Small-scale

0.249

Low

918462

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

919485

CRH1
Congo red hypersensitive protein 1 [Includes: Chitinase CRH1

1

0

High-throughput

0.249

Low

1025045

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.249

Low

1038402

RL21A
Large ribosomal subunit protein eL21A

1

0

High-throughput

0.249

Low

1043922

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low

1044003

GIR2
Protein GIR2

1

0

High-throughput

0.249

Low

1046309

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

668466

SPTC1
Serine palmitoyltransferase 1

1

0

High-throughput

0.238

Low

394927

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

450648

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.232

Low

453803

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

510838

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.232

Low

592515

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

597561

EF3A
Elongation factor 3A

1

0

High-throughput

0.232

Low

626892

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.232

Low

744400

ATC5
Phospholipid-transporting ATPase DNF1

1

0

High-throughput

0.232

Low

836907

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

863751

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

865082

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.232

Low

1050647

NUP59
Nucleoporin ASM4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025