HitPredict

Interactor 1: BUB1B (O60566)
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1)
Gene: BUB1B

Interactor 2: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.89 0.60 0.733

The method score is based on:

Property Details
Experiments 19503101, 17376779, 26323689, 28410192, 23455478, 24067371
Identification Methods affinity chromatography technology, enzymatic study, pull down
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000776 - kinetochore
GO:0000940 - outer kinetochore
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
and 8 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 1050
Hs

1 603
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+ At
+ Rn
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+ At
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+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024