HitPredict

Interactor 1: BUB1B (O60566)
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1)
Gene: BUB1B

Interactor 2: APC7 (Q9UJX3)
Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7)
Gene: ANAPC7

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.741

Property	Details
Experiments	26986935, 28404789, 10477750, 32707033, 20360068, 23160376, 23288039
Identification Methods	affinity chromatography technology, tandem affinity purification, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005680 - anaphase-promoting complex GO:0005819 - spindle GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1050 Hs			1 565
+	Hs
		236919 BUB1B_HUMAN (1-1050): 0: 826: 100.00		CDC16_HUMAN (134-544): 8.61e-16: 82.5: 12.56
+	Hs
		236987 BUB1B_HUMAN (1-1050): 0: 826: 100.00		CDC23_HUMAN (241-545): 1.19e-12: 72.5: 12.04
+	Hs
		236886 BUB1B_HUMAN (1-1050): 0: 826: 100.00		CDC27_HUMAN (20-196): 9.88e-12: 69.8: 10.70
+	Hs
		211010 BUB1_HUMAN (53-1042): 1.59e-170: 531: 19.04		CDC16_HUMAN (134-544): 8.61e-16: 82.5: 12.56
+	Hs
		174862 KCC2D_HUMAN (764-1021): 2.99e-96: 316: 16.61		OGT1_HUMAN (206-561): 2.13e-62: 223: 17.55
+	Hs
		160839 AURKA_HUMAN (671-986): 1.25e-38: 151: 16.01		APC7_HUMAN (1-565): 2.26e-104: 327: 100.00
+	Sp
		223612 MAD3_SCHPO (20-351): 3.73e-81: 268: 25.00		CUT9_SCHPO (9-521): 1.18e-51: 189: 13.36
+	Hs
		174861 KCC2G_HUMAN (764-985): 5.89e-62: 223: 19.05		OGT1_HUMAN (206-561): 2.13e-62: 223: 17.55
+	Hs
		174860 KCC2B_HUMAN (764-985): 1.06e-58: 216: 17.75		OGT1_HUMAN (206-561): 2.13e-62: 223: 17.55
+	Hs
		175311 KCC2A_HUMAN (764-985): 1.69e-60: 216: 17.75		OGT1_HUMAN (206-561): 2.13e-62: 223: 17.55
+	Rn
		506706 KCC2A_RAT (764-985): 1.69e-60: 216: 17.75		OGT1_RAT (22-406): 1.16e-49: 186: 11.34
+	Dm
		51410 A1Z6I7_DROME (173-1026): 8.59e-85: 302: 15.32		Q9VS37_DROME (13-269): 9.28e-18: 89.1: 11.83
+	Sp
		223611 MAD3_SCHPO (20-351): 3.73e-81: 268: 25.00		APC3_SCHPO (2-301): 1.35e-12: 72.5: 10.13
+	Sp
		223608 MAD3_SCHPO (20-351): 3.73e-81: 268: 25.00		APC8_SCHPO (227-545): 5.78e-10: 64: 11.37
+	Hs
		160541 AURKA_HUMAN (671-986): 1.25e-38: 151: 16.01		CDC16_HUMAN (134-544): 8.61e-16: 82.5: 12.56
+	Hs
		160838 AURKA_HUMAN (671-986): 1.25e-38: 151: 16.01		CDC23_HUMAN (241-545): 1.19e-12: 72.5: 12.04
+	Hs
		160401 AURKA_HUMAN (671-986): 1.25e-38: 151: 16.01		CDC27_HUMAN (20-196): 9.88e-12: 69.8: 10.70