HitPredict

Interactor 1: PLOD3 (O60568)
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)]
Gene: PLOD3

Interactor 2: COHA1 (Q9UMD9)
Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)]
Gene: COL17A1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0005788 - endoplasmic reticulum lumen GO:0062023 - collagen-containing extracellular matrix
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 738 Hs			1 1497
+	Hs
		237006 PLOD3_HUMAN (1-738): 0: 1310: 100.00		CO4A1_HUMAN (384-882): 2.54e-50: 198: 26.22
+	Hs
		237005 PLOD3_HUMAN (1-738): 0: 1310: 100.00		CO1A1_HUMAN (856-1496): 6.44e-48: 190: 22.87
+	Hs
		237052 PLOD3_HUMAN (1-738): 0: 1310: 100.00		CO4A6_HUMAN (366-728): 7.18e-29: 128: 23.63
+	Hs
		237016 PLOD3_HUMAN (1-738): 0: 1310: 100.00		CO4A2_HUMAN (367-728): 9.78e-28: 124: 24.59
+	Hs
		129876 PLOD2_HUMAN (19-738): 0: 1217: 58.75		CO1A1_HUMAN (856-1496): 6.44e-48: 190: 22.87
+	Hs
		237020 PLOD3_HUMAN (1-738): 0: 1310: 100.00		CO6A2_HUMAN (815-1045): 9.49e-19: 95.1: 32.73
+	Hs
		237133 PLOD3_HUMAN (1-738): 0: 1310: 100.00		MARCO_HUMAN (559-686): 1.33e-13: 77.4: 43.75
+	Hs
		237019 PLOD3_HUMAN (1-738): 0: 1310: 100.00		CO6A1_HUMAN (784-1046): 9.45e-12: 72: 37.12
+	Hs
		358661 PLOD1_HUMAN (32-738): 0: 1184: 59.38		CO4A1_HUMAN (384-882): 2.54e-50: 198: 26.22
+	Hs
		237111 PLOD3_HUMAN (1-738): 0: 1310: 100.00		COLA1_HUMAN (1146-1488): 1.06e-10: 68.6: 28.99
+	Hs
		358499 PLOD1_HUMAN (32-738): 0: 1184: 59.38		CO1A1_HUMAN (856-1496): 6.44e-48: 190: 22.87
+	Hs
		358604 PLOD1_HUMAN (32-738): 0: 1184: 59.38		CO2A1_HUMAN (366-701): 5.87e-30: 131: 24.04
+	Hs
		129885 PLOD2_HUMAN (19-738): 0: 1217: 58.75		CO6A2_HUMAN (815-1045): 9.49e-19: 95.1: 32.73
+	Hs
		972738 PLOD1_HUMAN (32-738): 0: 1184: 59.38		CO4A6_HUMAN (366-728): 7.18e-29: 128: 23.63
+	Hs
		441060 PLOD1_HUMAN (32-738): 0: 1184: 59.38		CO4A2_HUMAN (367-728): 9.78e-28: 124: 24.59
+	Hs
		596157 PLOD1_HUMAN (32-738): 0: 1184: 59.38		CO5A1_HUMAN (389-887): 1.03e-21: 105: 27.18
+	Hs
		129937 PLOD2_HUMAN (19-738): 0: 1217: 58.75		COLA1_HUMAN (1146-1488): 1.06e-10: 68.6: 28.99
+	Hs
		517998 PLOD1_HUMAN (32-738): 0: 1184: 59.38		CO6A2_HUMAN (815-1045): 9.49e-19: 95.1: 32.73
+	Hs
		862503 PLOD1_HUMAN (32-738): 0: 1184: 59.38		CO4A4_HUMAN (1067-1485): 1.02e-16: 88.8: 18.12
+	Hs
		517941 PLOD1_HUMAN (32-738): 0: 1184: 59.38		CO6A1_HUMAN (784-1046): 9.45e-12: 72: 37.12