Interactor 1: IF4E2 (O60573)
Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (Eukaryotic translation initiation factor 4E homologous protein) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) (mRNA cap-binding protein 4EHP) (h4EHP) (mRNA cap-binding protein type 3)
Gene: EIF4E2
Interactor 2: 4EBP1 (Q13541)
Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)
Gene: EIF4EBP1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.87 | 1.00 | 0.935 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 32296183, 33961781, 15094042, 17368478, 28698298 |
| Identification Methods | two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, isothermal titration calorimetry, pull down, x-ray crystallography, coimmunoprecipitation |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | IF4E~eIF_4EBP |
| Common GO terms | GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0017148 - negative regulation of translation GO:0045947 - negative regulation of translational initiation |
| Homologous interactions | 15 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
