Interactor 1: HCN1 (O60741)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1)
Gene: HCN1

Interactor 2: HCN2 (Q9UL51)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2)
Gene: HCN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.67 1.00 0.821

The method score is based on:

Property Details
Experiments 12928435, 12034718, 37207277
Identification Methods affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains cNMP_binding~cNMP_binding, Ion_trans~cNMP_binding, Ion_trans_N~cNMP_binding, Ion_trans~Ion_trans, Ion_trans~Ion_trans_N
Common GO terms GO:0003254 - regulation of membrane depolarization
GO:0005222 - intracellularly cAMP-activated cation channel activity
GO:0005248 - voltage-gated sodium channel activity
GO:0005249 - voltage-gated potassium channel activity
GO:0005886 - plasma membrane
and 8 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 890
Hs

1 889
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+ Mm
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024