Protein: PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (EC 3.1.3.27) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase) (Protein-tyrosine phosphatase mitochondrial 1) (EC 3.1.3.16, EC 3.1.3.48)

Gene: PTPM1, PTPMT1
Organism: Homo sapiens
Interactions: 193
UniProt ID: Q8WUK0

Gene Ontology (top 5):
GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004722 - protein serine/threonine phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1356877

CLPB
Mitochondrial disaggregase

2

3

High-throughput

0.754

High

1356861

MDFI
MyoD family inhibitor

4

1

High-throughput

0.703

High

303169

RGS20
Regulator of G-protein signaling 20

4

1

High-throughput

0.700

High

1356865

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

3

1

High-throughput

0.667

High

1161160

MK06
Mitogen-activated protein kinase 6

1

20

High-throughput

0.656

High

846770

GRK6
G protein-coupled receptor kinase 6

1

2

High-throughput

0.618

High

1289358

ST32C
Serine/threonine-protein kinase 32C

1

3

High-throughput

0.618

High

1331587

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

16

High-throughput

0.618

High

322274

GLSK
Glutaminase kidney isoform, mitochondrial

1

4

High-throughput

0.618

High

1163853

DUS6
Dual specificity protein phosphatase 6

1

16

High-throughput

0.618

High

1356845

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

18

High-throughput

0.618

High

1356895

PAK5
Serine/threonine-protein kinase PAK 5

1

3

High-throughput

0.618

High

685916

KRA59
Keratin-associated protein 5-9

3

10

High-throughput

0.616

High

950350

KR107
Keratin-associated protein 10-7

3

8

High-throughput

0.616

High

950600

KR108
Keratin-associated protein 10-8

3

9

High-throughput

0.616

High

1146070

K1H1
Keratin, type I cuticular Ha1

3

3

High-throughput

0.616

High

1356872

KRA92
Keratin-associated protein 9-2

3

10

High-throughput

0.616

High

1356874

XPO4
Exportin-4

2

5

High-throughput

0.611

High

349691

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

2

0

High-throughput

0.602

High

914683

RM12
Large ribosomal subunit protein bL12m

2

0

High-throughput

0.602

High

869201

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

2

0

High-throughput

0.585

High

1277332

NT2NA
Notch homolog 2 N-terminal-like protein A

2

1

High-throughput

0.578

High

562266

LAMP2
Lysosome-associated membrane glycoprotein 2

2

1

High-throughput

0.574

High

926811

VMAT1
Chromaffin granule amine transporter

2

3

High-throughput

0.574

High

1128929

I13R2
Interleukin-13 receptor subunit alpha-2

2

9

High-throughput

0.574

High

572096

TRI27
Zinc finger protein RFP

1

4

High-throughput

0.573

High

1205905

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

8

High-throughput

0.573

High

1307757

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

1

High-throughput

0.573

High

1162441

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

1356846

NU133
Nuclear pore complex protein Nup133

2

2

High-throughput

0.558

High

300443

KRT34
Keratin, type I cuticular Ha4

2

3

High-throughput

0.553

High

950845

KR109
Keratin-associated protein 10-9

2

9

High-throughput

0.553

High

1235798

KRA57
Keratin-associated protein 5-7

2

9

High-throughput

0.553

High

1307421

KRA13
Keratin-associated protein 1-3

2

9

High-throughput

0.553

High

1356864

KR412
Keratin-associated protein 4-12

2

11

High-throughput

0.553

High

1356871

KRA93
Keratin-associated protein 9-3

2

10

High-throughput

0.553

High

845089

EAA3
Excitatory amino acid transporter 3

2

1

High-throughput

0.549

High

174011

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

3

High-throughput

0.536

High

449616

KLK1
Kallikrein-1

1

1

High-throughput

0.536

High

854187

KI67
Proliferation marker protein Ki-67

1

2

High-throughput

0.536

High

1125569

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

9

High-throughput

0.536

High

1356885

JMJD4
2-oxoglutarate and iron-dependent oxygenase JMJD4

1

4

High-throughput

0.536

High

505363

KRA23
Keratin-associated protein 2-3

1

10

High-throughput

0.523

High

1230166

K1C40
Keratin, type I cytoskeletal 40

1

3

High-throughput

0.523

High

280942

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.513

High

1341273

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.513

High

1356876

S22A4
Solute carrier family 22 member 4

1

0

High-throughput

0.513

High

1153074

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

1

High-throughput

0.508

High

64891

RCCD1
RCC1 domain-containing protein 1

1

3

High-throughput

0.489

High

391382

FRIL
Ferritin light chain

1

1

High-throughput

0.489

High

598155

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

3

High-throughput

0.489

High

1053040

VMAT2
Synaptic vesicular amine transporter

1

2

High-throughput

0.489

High

1350582

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

1

High-throughput

0.489

High

1356859

IPO9
Importin-9

1

10

High-throughput

0.489

High

221620

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

1

High-throughput

0.479

High

242399

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

249496

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

2

High-throughput

0.479

High

282019

MPPB
Mitochondrial-processing peptidase subunit beta

1

6

High-throughput

0.479

High

298758

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

1

High-throughput

0.479

High

343428

SNP29
Synaptosomal-associated protein 29

1

1

High-throughput

0.479

High

471150

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

614714

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

5

High-throughput

0.479

High

634144

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

1

High-throughput

0.479

High

651844

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

6

High-throughput

0.479

High

662795

CPT2
Carnitine O-palmitoyltransferase 2, mitochondrial

1

1

High-throughput

0.479

High

714294

PML
Protein PML

1

6

High-throughput

0.479

High

774521

BASI
Basigin

1

8

High-throughput

0.479

High

784669

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

1

High-throughput

0.479

High

831124

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

841843

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

14

High-throughput

0.479

High

869928

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

1

High-throughput

0.479

High

913364

MSH6
DNA mismatch repair protein Msh6

1

5

High-throughput

0.479

High

916310

TXTP
Tricarboxylate transport protein, mitochondrial

1

1

High-throughput

0.479

High

934122

XPO2
Exportin-2

1

14

High-throughput

0.479

High

937832

FOXA1
Hepatocyte nuclear factor 3-alpha

1

3

High-throughput

0.479

High

962315

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

1024415

S25A3
Solute carrier family 25 member 3

1

3

High-throughput

0.479

High

1058167

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1090475

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.479

High

1092601

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

3

High-throughput

0.479

High

1130123

SMC1A
Structural maintenance of chromosomes protein 1A

1

8

High-throughput

0.479

High

1138431

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

1149451

SKI2
Superkiller complex protein 2

1

8

High-throughput

0.479

High

1164486

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.479

High

1192069

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

1

High-throughput

0.479

High

1205122

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

1

High-throughput

0.479

High

1337200

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

1356850

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.479

High

1356851

TNPO1
Transportin-1

1

12

High-throughput

0.479

High

1356852

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

1356853

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

1356854

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.479

High

1356855

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

2

High-throughput

0.479

High

1356858

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1356867

TMM70
Transmembrane protein 70, mitochondrial

1

3

High-throughput

0.479

High

1356870

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

1356875

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

1356878

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

2

High-throughput

0.479

High

1356882

HEAT1
HEAT repeat-containing protein 1

1

2

High-throughput

0.479

High

1356883

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

2

High-throughput

0.479

High

1356884

SFXN1
Sideroflexin-1

1

2

High-throughput

0.479

High

1356891

ATD3A
ATPase family AAA domain-containing protein 3A

1

12

High-throughput

0.479

High

1356892

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

1356897

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.479

High

1356898

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1356899

STML2
Stomatin-like protein 2, mitochondrial

1

4

High-throughput

0.479

High

1356900

DICER
Endoribonuclease Dicer

1

11

High-throughput

0.479

High

1356901

SMC3
Structural maintenance of chromosomes protein 3

1

8

High-throughput

0.479

High

1356903

PDIP2
Polymerase delta-interacting protein 2

1

3

High-throughput

0.479

High

1356906

TELO2
Telomere length regulation protein TEL2 homolog

1

2

High-throughput

0.479

High

1356907

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

5

High-throughput

0.479

High

1356908

DJC15
DnaJ homolog subfamily C member 15

1

1

High-throughput

0.479

High

1356909

MTCH2
Mitochondrial carrier homolog 2

1

9

High-throughput

0.479

High

517073

NT2NC
Notch homolog 2 N-terminal-like protein C

1

1

High-throughput

0.470

High

275072

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

283917

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.458

High

301930

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.458

High

329311

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.458

High

519174

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

572375

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

1

0

High-throughput

0.458

High

577996

QCR7
Cytochrome b-c1 complex subunit 7

1

0

High-throughput

0.458

High

617559

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.458

High

665646

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

High-throughput

0.458

High

828866

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

909456

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

1

0

High-throughput

0.458

High

938857

SCOT1
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

1

0

High-throughput

0.458

High

940614

ATP5E
ATP synthase F(1) complex subunit epsilon, mitochondrial

1

0

High-throughput

0.458

High

1023582

CYC
Cytochrome c

1

0

High-throughput

0.458

High

1109562

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

0

Small-scale

0.458

High

1141517

OXA1L
Mitochondrial inner membrane protein OXA1L

1

0

High-throughput

0.458

High

1149599

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

1207082

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1229584

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1270585

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

1323208

NDUF2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2

1

0

High-throughput

0.458

High

1356857

ATPMK
ATP synthase F(0) complex subunit k, mitochondrial

1

0

High-throughput

0.458

High

1356860

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

1356862

COQ7
NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial

1

0

High-throughput

0.458

High

1356863

NIPS1
Protein NipSnap homolog 1

1

0

High-throughput

0.458

High

1356866

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

1356868

RCAF1
GEL complex subunit OPTI

1

0

High-throughput

0.458

High

1356880

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

1356887

HINT3
Adenosine 5'-monophosphoramidase HINT3

1

0

High-throughput

0.458

High

1356894

CISD1
CDGSH iron-sulfur domain-containing protein 1

1

0

High-throughput

0.458

High

1356905

TIM16
Mitochondrial import inner membrane translocase subunit TIM16

1

0

High-throughput

0.458

High

1356910

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

372676

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.445

High

1323733

S39AB
Zinc transporter ZIP11

1

1

High-throughput

0.445

High

589

NBPFJ
NBPF family member NBPF19

1

4

High-throughput

0.439

High

949951

KR103
Keratin-associated protein 10-3

1

10

High-throughput

0.439

High

1059702

KRA11
Keratin-associated protein 1-1

1

9

High-throughput

0.439

High

189236

IPO8
Importin-8

1

10

High-throughput

0.437

High

220956

XPOT
Exportin-T

1

12

High-throughput

0.437

High

294083

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

317899

LTN1
E3 ubiquitin-protein ligase listerin

1

2

High-throughput

0.437

High

916005

NUP98
Nuclear pore complex protein Nup98-Nup96

1

3

High-throughput

0.437

High

1015630

RHOG
Rho-related GTP-binding protein RhoG

1

4

High-throughput

0.437

High

1085257

NU160
Nuclear pore complex protein Nup160

1

1

High-throughput

0.437

High

1277506

MON2
Protein MON2 homolog

1

1

High-throughput

0.437

High

1327098

FBXL6
F-box/LRR-repeat protein 6

1

4

High-throughput

0.437

High

1356848

GCN1
Stalled ribosome sensor GCN1

1

15

High-throughput

0.437

High

1356849

NU205
Nuclear pore complex protein Nup205

1

5

High-throughput

0.437

High

1356881

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

1356888

ANLN
Anillin

1

1

High-throughput

0.437

High

1356889

FBX6
F-box only protein 6

1

1

High-throughput

0.437

High

1356896

ATX10
Ataxin-10

1

1

High-throughput

0.437

High

1356902

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

2

High-throughput

0.437

High

1356904

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

844950

EAA2
Excitatory amino acid transporter 2

1

1

High-throughput

0.407

High

1356886

S39A2
Zinc transporter ZIP2

1

1

High-throughput

0.407

High

70384

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

705485

GRN
Progranulin

2

0

High-throughput

0.316

High

949604

KR123
Keratin-associated protein 12-3

2

0

High-throughput

0.316

High

1215186

LCE2C
Late cornified envelope protein 2C

2

0

High-throughput

0.316

High

1250269

ATL4
ADAMTS-like protein 4

2

0

High-throughput

0.316

High

1356873

KRA31
Keratin-associated protein 3-1

2

0

High-throughput

0.316

High

1356890

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

260782

RAMP2
Receptor activity-modifying protein 2

1

0

High-throughput

0.279

Low

549837

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

0

High-throughput

0.279

Low

1325880

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

1356847

AQP3
Aquaporin-3

1

0

High-throughput

0.279

Low

1356879

CAD23
Cadherin-23

1

0

High-throughput

0.279

Low

1356080

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

0

High-throughput

0.251

Low

925574

MOT1
Monocarboxylate transporter 1

1

0

High-throughput

0.249

Low

1126135

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1178277

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1249052

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1356856

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1356869

NUP85
Nuclear pore complex protein Nup85

1

0

High-throughput

0.249

Low

1356893

DJC28
DnaJ homolog subfamily C member 28

1

0

High-throughput

0.249

Low

538794

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

0

High-throughput

0.232

Low

1203514

S45A4
Solute carrier family 45 member 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025