HitPredict

Interactor 1: SNX2 (O60749)
Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9)
Gene: SNX2

Interactor 2: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005158 - insulin receptor binding GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 519 Hs			1 1367
+	Hs
		435636 SNX1_HUMAN (2-519): 1.54e-123: 373: 59.32		IGF1R_HUMAN (1-1367): 0: 1387: 100.00
+	Mm
		1141340 SNX9_MOUSE (2-515): 8.45e-91: 291: 15.49		IGF1R_MOUSE (1-1367): 0: 1386: 94.98
+	Hs
		240332 SNX2_HUMAN (1-519): 5.7e-150: 440: 100.00		INSR_HUMAN (32-1365): 0: 1219: 56.54
+	Rn
		71355 B2RYP4_RAT (1-519): 4.37e-147: 433: 97.69		INSR_RAT (20-1365): 0: 1210: 55.45
+	Hs
		435813 SNX5_HUMAN (123-517): 2.28e-68: 227: 22.89		IGF1R_HUMAN (1-1367): 0: 1387: 100.00
+	Hs
		435805 SNX6_HUMAN (113-517): 4.05e-68: 226: 19.06		IGF1R_HUMAN (1-1367): 0: 1387: 100.00
+	Hs
		411380 SNX1_HUMAN (2-519): 1.54e-123: 373: 59.32		INSR_HUMAN (32-1365): 0: 1219: 56.54
+	Mm
		546277 SNX9_MOUSE (2-515): 8.45e-91: 291: 15.49		INSR_MOUSE (20-1365): 0: 1219: 56.40
+	Hs
		307875 SNX4_HUMAN (93-513): 2.45e-73: 241: 18.20		INSR_HUMAN (32-1365): 0: 1219: 56.54
+	Hs
		411539 SNX5_HUMAN (123-517): 2.28e-68: 227: 22.89		INSR_HUMAN (32-1365): 0: 1219: 56.54
+	Hs
		411527 SNX6_HUMAN (113-517): 4.05e-68: 226: 19.06		INSR_HUMAN (32-1365): 0: 1219: 56.54
+	Hs
		240370 SNX2_HUMAN (1-519): 5.7e-150: 440: 100.00		EPHA5_HUMAN (666-1275): 2.52e-173: 545: 24.01
+	Hs
		240327 SNX2_HUMAN (1-519): 5.7e-150: 440: 100.00		NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61
+	Hs
		240342 SNX2_HUMAN (1-519): 5.7e-150: 440: 100.00		FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54
+	Hs
		384801 SNX1_HUMAN (2-519): 1.54e-123: 373: 59.32		NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61
+	Hs
		674416 SNX1_HUMAN (2-519): 1.54e-123: 373: 59.32		UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10
+	Hs
		507986 SNX1_HUMAN (2-519): 1.54e-123: 373: 59.32		FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54
+	Hs
		385804 SNX9_HUMAN (3-515): 6.14e-93: 296: 16.64		NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61
+	Hs
		1081648 SNX7_HUMAN (112-512): 6e-80: 256: 22.44		NTRK3_HUMAN (977-1262): 5.74e-64: 236: 39.16
+	Hs
		445888 SNX5_HUMAN (123-517): 2.28e-68: 227: 22.89		ROS1_HUMAN (691-919): 7.36e-11: 69.4: 17.47