Protein: ALDH2
Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI)

Gene: ALDH2
Organism: Homo sapiens
Interactions: 121
UniProt ID: P05091

Gene Ontology (top 5):
GO:0004029 - aldehyde dehydrogenase (NAD+) activity
GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005975 - carbohydrate metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

317232

AL1A2
Retinal dehydrogenase 2

3

14

High-throughput

0.861

High

423894

MMSA
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial

3

14

High-throughput

0.861

High

358865

AL1A1
Aldehyde dehydrogenase 1A1

2

15

High-throughput

0.793

High

423881

AL1B1
Aldehyde dehydrogenase X, mitochondrial

2

15

High-throughput

0.789

High

387683

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

3

2

High-throughput

0.667

High

387774

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

3

2

High-throughput

0.667

High

387935

FIBG
Fibrinogen gamma chain

3

2

High-throughput

0.667

High

423868

ALDH2
Aldehyde dehydrogenase, mitochondrial

1

14

Small-scale

0.647

High

369294

A1AT
Alpha-1-antitrypsin

3

0

High-throughput

0.638

High

387205

APOA1
Apolipoprotein A-I

3

0

High-throughput

0.638

High

390843

TRFE
Serotransferrin

3

0

High-throughput

0.638

High

423875

TAU
Microtubule-associated protein tau

2

4

High-throughput

0.628

High

423948

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

2

7

Small-scale

0.611

High

423917

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

2

High-throughput

0.611

High

423883

SPB5
Serpin B5

3

1

High-throughput

0.609

High

423876

CH60
60 kDa heat shock protein, mitochondrial

2

4

Small-scale

0.586

High

240477

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

423911

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

2

High-throughput

0.584

High

423889

TERA
Transitional endoplasmic reticulum ATPase

2

5

High-throughput

0.571

High

379415

IGHG3
Immunoglobulin heavy constant gamma 3

2

4

High-throughput

0.552

High

379448

IGHG4
Immunoglobulin heavy constant gamma 4

2

6

High-throughput

0.552

High

423933

TR61B
tRNA

2

0

High-throughput

0.547

High

423902

CUL3
Cullin-3

1

3

High-throughput

0.536

High

423907

ICT1
Large ribosomal subunit protein mL62

1

2

High-throughput

0.536

High

423914

A16L1
Autophagy-related protein 16-1

2

6

High-throughput

0.521

High

423919

S35F6
Solute carrier family 35 member F6

1

0

High-throughput

0.518

High

421285

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

423906

DPYL1
Dihydropyrimidinase-related protein 1

1

3

High-throughput

0.494

High

127622

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

1

High-throughput

0.489

High

213768

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

High-throughput

0.489

High

423905

PKP1
Plakophilin-1

1

2

High-throughput

0.489

High

423909

MYLK
Myosin light chain kinase, smooth muscle

1

1

High-throughput

0.489

High

423938

KPCD2
Serine/threonine-protein kinase D2

1

1

High-throughput

0.489

High

279614

CISY
Citrate synthase, mitochondrial

1

1

High-throughput

0.479

High

281855

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

400101

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

411175

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

423872

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

4

High-throughput

0.479

High

423885

MDHM
Malate dehydrogenase, mitochondrial

1

3

High-throughput

0.479

High

423888

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.479

High

423896

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

High-throughput

0.479

High

423897

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.479

High

423904

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

423908

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

423915

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

423920

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

423928

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

423929

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

423934

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

423943

MTG2
Mitochondrial ribosome-associated GTPase 2

1

5

High-throughput

0.479

High

423946

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

423949

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

423877

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.470

High

423910

HSPB2
Heat shock protein beta-2

1

1

High-throughput

0.464

High

423890

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.460

High

423893

CH10
10 kDa heat shock protein, mitochondrial

1

0

Small-scale

0.460

High

61398

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

350764

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

423878

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

423879

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

423886

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

423895

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

423898

TADBP
TAR DNA-binding protein 43

1

0

Small-scale

0.458

High

423924

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

423925

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

423926

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

423937

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

423941

MTRFR
Mitochondrial translation release factor in rescue

1

0

High-throughput

0.458

High

423945

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

423952

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

185348

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

High-throughput

0.457

High

379064

IGKC
Immunoglobulin kappa constant

1

4

High-throughput

0.445

High

379188

IGHG1
Immunoglobulin heavy constant gamma 1

1

6

High-throughput

0.445

High

379604

IGHA1
Immunoglobulin heavy constant alpha 1

1

6

High-throughput

0.445

High

423870

HEPS
Serine protease hepsin

1

1

High-throughput

0.445

High

423874

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

1

High-throughput

0.445

High

423912

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

423947

ITM2C
Integral membrane protein 2C

1

1

High-throughput

0.445

High

423958

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

7

High-throughput

0.445

High

423884

RL13A
Large ribosomal subunit protein uL13

1

1

High-throughput

0.439

High

105111

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

142786

NFIB
Nuclear factor 1 B-type

1

1

High-throughput

0.437

High

385359

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.437

High

423873

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.437

High

423880

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

423882

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

423887

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.437

High

423901

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.437

High

423903

CUL4A
Cullin-4A

1

3

High-throughput

0.437

High

423916

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

423930

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.437

High

423935

FACD2
Fanconi anemia group D2 protein

1

3

High-throughput

0.437

High

423942

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

423944

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

423953

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.437

High

423956

FBW1A
F-box/WD repeat-containing protein 1A

1

3

Small-scale

0.437

High

423957

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.437

High

261058

NSMA
Sphingomyelin phosphodiesterase 2

1

2

High-throughput

0.407

High

423869

JUN
Transcription factor Jun

1

2

High-throughput

0.407

High

423871

PRGR
Progesterone receptor

1

1

Small-scale

0.407

High

423891

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.407

High

423913

CP135
Centrosomal protein of 135 kDa

1

2

High-throughput

0.407

High

423931

PKP2
Plakophilin-2

1

2

High-throughput

0.407

High

423940

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

5

High-throughput

0.407

High

423951

CALL5
Calmodulin-like protein 5

3

0

High-throughput

0.347

High

423900

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.282

High

423927

IGS21
Immunoglobulin superfamily member 21

1

0

High-throughput

0.282

High

423954

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.282

High

423923

NEK7
Serine/threonine-protein kinase Nek7

1

0

High-throughput

0.279

Low

423939

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

0

High-throughput

0.279

Low

423921

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.249

Low

423950

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

423899

CENPR
Centromere protein R

1

0

High-throughput

0.238

Low

423922

DEN10
DENN domain-containing protein 10

1

0

High-throughput

0.238

Low

330017

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

423892

SMS
Somatostatin

1

0

Small-scale

0.232

Low

423918

DND1
Dead end protein homolog 1

1

0

High-throughput

0.232

Low

423932

MCRI2
MAPK regulated corepressor interacting protein 2

1

0

High-throughput

0.232

Low

423936

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

0

High-throughput

0.232

Low

423955

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025