HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.57 1.00 0.759

The method score is based on:

Property Details
Experiments 29995846, 32814053
Identification Methods x-ray crystallography, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains IBR_2~ubiquitin, ubiquitin~ubiquitin, ubiquitin~zf-RING_12, ubiquitin~zf-RING_14
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005789 - endoplasmic reticulum membrane
and 5 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 465
Hs

1 229
+ Hs
+ Rn
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Bt
+ Hs
+ At
+ Mm
+ Dm
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025