Protein: ARI1
E3 ubiquitin-protein ligase ARIH1 (EC 2.3.2.31) (H7-AP2) (HHARI) (Monocyte protein 6) (MOP-6) (Protein ariadne-1 homolog) (ARI-1) (UbcH7-binding protein) (UbcM4-interacting protein) (Ubiquitin-conjugating enzyme E2-binding protein 1)

Gene: ARI1, ARIH1
Organism: Homo sapiens
Interactions: 224
UniProt ID: Q9Y4X5

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

996048

UB2L3
Ubiquitin-conjugating enzyme E2 L3

20

20

Small-scale

0.991

High

1491465

ARI1
E3 ubiquitin-protein ligase ARIH1

12

18

Small-scale

0.978

High

1112817

CUL1
Cullin-1

5

15

Small-scale

0.939

High

1114753

CUL3
Cullin-3

5

15

Small-scale

0.922

High

1154971

NEDD8
Ubiquitin-like protein NEDD8

4

10

Small-scale

0.893

High

906836

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

20

Small-scale

0.888

High

508895

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

20

Small-scale

0.862

High

984038

RBX1
E3 ubiquitin-protein ligase RBX1

3

6

Small-scale

0.853

High

243399

PRKN
E3 ubiquitin-protein ligase parkin

3

16

Small-scale

0.827

High

1403676

UHRF1
E3 ubiquitin-protein ligase UHRF1

2

5

High-throughput

0.811

High

1113038

CUL2
Cullin-2

2

15

Small-scale

0.789

High

957255

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.778

High

957876

UBE2N
Ubiquitin-conjugating enzyme E2 N

2

20

Small-scale

0.768

High

1147317

ELOB
Elongin-B

2

2

High-throughput

0.754

High

1461023

FBW1B
F-box/WD repeat-containing protein 11

7

11

High-throughput

0.745

High

1490651

FBW1A
F-box/WD repeat-containing protein 1A

4

11

High-throughput

0.697

High

1433168

FXL15
F-box/LRR-repeat protein 15

4

4

High-throughput

0.694

High

1115169

CUL4A
Cullin-4A

1

15

Small-scale

0.691

High

1358001

RN138
E3 ubiquitin-protein ligase RNF138

1

17

High-throughput

0.691

High

1420552

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

16

High-throughput

0.691

High

430559

JUN
Transcription factor Jun

4

11

High-throughput

0.691

High

667023

CCNE1
G1/S-specific cyclin-E1

4

3

Small-scale

0.683

High

227724

SPOP
Speckle-type POZ protein

3

10

Small-scale

0.670

High

279553

TULP3
Tubby-related protein 3

3

1

High-throughput

0.667

High

605278

ATF7
Cyclic AMP-dependent transcription factor ATF-7

3

10

High-throughput

0.667

High

1117935

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

3

7

High-throughput

0.667

High

1271429

KCTD9
BTB/POZ domain-containing protein KCTD9

3

7

High-throughput

0.667

High

1290317

KBTB6
Kelch repeat and BTB domain-containing protein 6

3

14

High-throughput

0.667

High

1312887

KLHL7
Kelch-like protein 7

3

13

High-throughput

0.667

High

1325105

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

3

4

High-throughput

0.667

High

1331479

ZFP41
Zinc finger protein 41 homolog

3

12

High-throughput

0.667

High

1358891

KBTB7
Kelch repeat and BTB domain-containing protein 7

3

15

High-throughput

0.667

High

1361878

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

3

7

High-throughput

0.667

High

1386856

ZN501
Zinc finger protein 501

3

8

High-throughput

0.667

High

1407188

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

3

5

High-throughput

0.667

High

1410292

KLDC3
Kelch domain-containing protein 3

3

12

High-throughput

0.667

High

1430182

PUS7L
Pseudouridylate synthase PUS7L

3

1

High-throughput

0.667

High

1431391

EPN3
Epsin-3

3

8

High-throughput

0.667

High

1432572

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

3

6

High-throughput

0.667

High

1436584

ECT2
Protein ECT2

3

9

High-throughput

0.667

High

1490943

KLDC2
Kelch domain-containing protein 2

3

14

High-throughput

0.667

High

992408

SKP1
S-phase kinase-associated protein 1

3

1

High-throughput

0.650

High

1460974

FBX3
F-box only protein 3

3

1

High-throughput

0.650

High

1397308

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

20

Small-scale

0.647

High

1447706

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

20

Small-scale

0.647

High

252206

IF4E2
Eukaryotic translation initiation factor 4E type 2

2

3

Small-scale

0.636

High

171950

ZN263
Zinc finger protein 263

2

15

High-throughput

0.628

High

282506

KTNA1
Katanin p60 ATPase-containing subunit A1

2

12

High-throughput

0.628

High

583617

ATF2
Cyclic AMP-dependent transcription factor ATF-2

2

9

High-throughput

0.628

High

593252

CREB1
Cyclic AMP-responsive element-binding protein 1

2

2

High-throughput

0.628

High

603698

JUNB
Transcription factor JunB

2

11

High-throughput

0.628

High

604882

HXB9
Homeobox protein Hox-B9

2

5

High-throughput

0.628

High

605097

JUND
Transcription factor JunD

2

9

High-throughput

0.628

High

617122

ATF1
Cyclic AMP-dependent transcription factor ATF-1

2

7

High-throughput

0.628

High

639334

TNAP3
Tumor necrosis factor alpha-induced protein 3

2

8

High-throughput

0.628

High

724951

HXA10
Homeobox protein Hox-A10

2

2

High-throughput

0.628

High

725166

HXC9
Homeobox protein Hox-C9

2

4

High-throughput

0.628

High

961495

ISL1
Insulin gene enhancer protein ISL-1

2

3

High-throughput

0.628

High

1028145

IRF9
Interferon regulatory factor 9

2

5

High-throughput

0.628

High

1039836

CREB5
Cyclic AMP-responsive element-binding protein 5

2

8

High-throughput

0.628

High

1252001

ZN852
Zinc finger protein 852

2

7

High-throughput

0.628

High

1335412

CAMKV
CaM kinase-like vesicle-associated protein

2

4

High-throughput

0.628

High

1359964

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

3

High-throughput

0.628

High

1361403

BBX
HMG box transcription factor BBX

2

1

High-throughput

0.628

High

1382437

ISL2
Insulin gene enhancer protein ISL-2

2

3

High-throughput

0.628

High

1398273

TEAN2
Transcription elongation factor A N-terminal and central domain-containing protein 2

2

1

High-throughput

0.628

High

1411525

PDD2L
Programmed cell death protein 2-like

2

2

High-throughput

0.628

High

1430410

DDX47
Probable ATP-dependent RNA helicase DDX47

2

15

High-throughput

0.628

High

1447989

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

2

8

High-throughput

0.628

High

1461221

FBXW2
F-box/WD repeat-containing protein 2

2

13

High-throughput

0.628

High

1350839

MAGE2
Melanoma-associated antigen E2

2

5

High-throughput

0.621

High

168583

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

20

Small-scale

0.618

High

799610

BRCA1
Breast cancer type 1 susceptibility protein

1

10

High-throughput

0.618

High

1100581

TIF1B
Transcription intermediary factor 1-beta

1

14

High-throughput

0.618

High

1256258

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.618

High

567198

ZNF35
Zinc finger protein 35

2

11

High-throughput

0.612

High

1348699

SHKB1
SH3KBP1-binding protein 1

3

7

High-throughput

0.609

High

1491467

KCTD3
BTB/POZ domain-containing protein KCTD3

3

7

High-throughput

0.609

High

1307251

TF2LY
Homeobox protein TGIF2LY

2

0

High-throughput

0.602

High

1402093

CRML
Protein cramped-like

2

0

High-throughput

0.602

High

1453686

THYN1
Thymocyte nuclear protein 1

2

0

High-throughput

0.602

High

1460978

FBXL5
F-box/LRR-repeat protein 5

2

0

High-throughput

0.602

High

1407828

HAUS7
HAUS augmin-like complex subunit 7

2

0

High-throughput

0.585

High

857366

CDN1B
Cyclin-dependent kinase inhibitor 1B

2

4

Small-scale

0.585

High

1380291

FBXW7
F-box/WD repeat-containing protein 7

2

11

Small-scale

0.584

High

1459446

ZRAN1
Ubiquitin thioesterase ZRANB1

2

16

High-throughput

0.584

High

1327537

SRBD1
S1 RNA-binding domain-containing protein 1

2

1

High-throughput

0.574

High

1419442

RHBT2
Rho-related BTB domain-containing protein 2

2

10

High-throughput

0.574

High

1199058

KLH12
Kelch-like protein 12

2

13

High-throughput

0.571

High

323924

SC31A
Protein transport protein Sec31A

1

11

High-throughput

0.561

High

1448345

FBX6
F-box only protein 6

2

0

High-throughput

0.559

High

1146895

PCBP1
Poly(rC)-binding protein 1

1

9

Small-scale

0.552

High

415961

HSPB1
Heat shock protein beta-1

1

2

High-throughput

0.541

High

209704

SERA
D-3-phosphoglycerate dehydrogenase

1

4

High-throughput

0.536

High

258012

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

2

High-throughput

0.536

High

271003

ZN623
Zinc finger protein 623

1

10

High-throughput

0.536

High

336245

ZIC2
Zinc finger protein ZIC 2

1

17

High-throughput

0.536

High

788832

SRP14
Signal recognition particle 14 kDa protein

1

1

High-throughput

0.536

High

857605

NOTC1
Neurogenic locus notch homolog protein 1

1

5

High-throughput

0.536

High

973856

RUXE
Small nuclear ribonucleoprotein E

1

1

High-throughput

0.536

High

1207354

ZN484
Zinc finger protein 484

1

10

High-throughput

0.536

High

1323554

ZN687
Zinc finger protein 687

1

12

High-throughput

0.536

High

1336901

ZN248
Zinc finger protein 248

1

8

High-throughput

0.536

High

1355995

SETD7
Histone-lysine N-methyltransferase SETD7

1

2

High-throughput

0.536

High

1413434

RBM42
RNA-binding protein 42

1

9

High-throughput

0.536

High

1428231

NDEL1
Nuclear distribution protein nudE-like 1

1

8

High-throughput

0.536

High

1491470

KC1G3
Casein kinase I isoform gamma-3

1

12

High-throughput

0.536

High

1322873

ZFP82
Zinc finger protein 82 homolog

1

3

High-throughput

0.515

High

884286

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

1052927

HME1
Homeobox protein engrailed-1

1

0

High-throughput

0.513

High

913688

VAV2
Guanine nucleotide exchange factor VAV2

1

6

High-throughput

0.508

High

1391983

DCNL1
DCN1-like protein 1

1

2

Small-scale

0.501

High

709316

CCN2
CCN family member 2

1

1

High-throughput

0.489

High

1022282

FBLN2
Fibulin-2

1

10

High-throughput

0.489

High

1290441

LRRT3
Leucine-rich repeat transmembrane neuronal protein 3

1

2

High-throughput

0.489

High

1331884

SYT2
Synaptotagmin-2

1

4

High-throughput

0.489

High

1157699

CRY1
Cryptochrome-1

1

0

High-throughput

0.480

High

163852

TCRG1
Transcription elongation regulator 1

1

7

High-throughput

0.479

High

168776

CSKP
Peripheral plasma membrane protein CASK

1

16

Small-scale

0.479

High

247055

KDM1A
Lysine-specific histone demethylase 1A

1

2

High-throughput

0.479

High

260651

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.479

High

272578

OBSL1
Obscurin-like protein 1

1

6

High-throughput

0.479

High

276542

PDCD6
Programmed cell death protein 6

1

10

High-throughput

0.479

High

281802

VP26A
Vacuolar protein sorting-associated protein 26A

1

3

High-throughput

0.479

High

316215

RECQ4
ATP-dependent DNA helicase Q4

1

16

High-throughput

0.479

High

329125

KLHL2
Kelch-like protein 2

1

13

High-throughput

0.479

High

344836

AP2A1
AP-2 complex subunit alpha-1

1

5

High-throughput

0.479

High

345133

RIGI
Antiviral innate immune response receptor RIG-I

1

19

Small-scale

0.479

High

703097

DPOD1
DNA polymerase delta catalytic subunit

1

3

High-throughput

0.479

High

719673

NMT1
Glycylpeptide N-tetradecanoyltransferase 1

1

1

High-throughput

0.479

High

821227

TXLNA
Alpha-taxilin

1

19

High-throughput

0.479

High

822926

VHL
von Hippel-Lindau disease tumor suppressor

1

1

High-throughput

0.479

High

831712

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

833396

PERI
Peripherin

1

18

High-throughput

0.479

High

855546

ATRX
Transcriptional regulator ATRX

1

9

High-throughput

0.479

High

863044

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

3

High-throughput

0.479

High

888581

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

6

High-throughput

0.479

High

891916

GSK3B
Glycogen synthase kinase-3 beta

1

6

Small-scale

0.479

High

927632

ATX1
Ataxin-1

1

2

High-throughput

0.479

High

935348

TERA
Transitional endoplasmic reticulum ATPase

1

8

High-throughput

0.479

High

936497

AFAD
Afadin

1

12

High-throughput

0.479

High

938307

SEC13
Protein SEC13 homolog

1

12

High-throughput

0.479

High

976791

ERF1
Eukaryotic peptide chain release factor subunit 1

1

3

High-throughput

0.479

High

981389

RAB1A
Ras-related protein Rab-1A

1

3

High-throughput

0.479

High

1017519

FOXK1
Forkhead box protein K1

1

2

High-throughput

0.479

High

1060507

DPOE1
DNA polymerase epsilon catalytic subunit A

1

3

High-throughput

0.479

High

1089617

ILF2
Interleukin enhancer-binding factor 2

1

5

High-throughput

0.479

High

1108319

SQSTM
Sequestosome-1

1

2

Small-scale

0.479

High

1119543

PEBB
Core-binding factor subunit beta

1

1

High-throughput

0.479

High

1122208

UBP2L
Ubiquitin-associated protein 2-like

1

10

High-throughput

0.479

High

1122922

SIM2
Single-minded homolog 2

1

5

Small-scale

0.479

High

1147158

ELOC
Elongin-C

1

2

High-throughput

0.479

High

1199485

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

12

High-throughput

0.479

High

1199768

KLH22
Kelch-like protein 22

1

13

High-throughput

0.479

High

1214690

RBM26
RNA-binding protein 26

1

9

High-throughput

0.479

High

1235957

PDE12
2',5'-phosphodiesterase 12

1

1

High-throughput

0.479

High

1244750

KLD10
Kelch domain-containing protein 10

1

13

High-throughput

0.479

High

1257850

ACD11
Acyl-CoA dehydrogenase family member 11

1

8

High-throughput

0.479

High

1293839

FBX11
F-box only protein 11

1

1

High-throughput

0.479

High

1336722

RCBT1
RCC1 and BTB domain-containing protein 1

1

10

High-throughput

0.479

High

1338455

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1339599

FBH1
F-box DNA helicase 1

1

1

High-throughput

0.479

High

1363365

DDX1
ATP-dependent RNA helicase DDX1

1

11

High-throughput

0.479

High

1363771

PSMF1
Proteasome inhibitor PI31 subunit

1

1

High-throughput

0.479

High

1366011

APBP2
Amyloid protein-binding protein 2

1

9

High-throughput

0.479

High

1370180

RENT1
Regulator of nonsense transcripts 1

1

3

High-throughput

0.479

High

1386649

OPTN
Optineurin

1

17

High-throughput

0.479

High

1395448

FEM1C
Protein fem-1 homolog C

1

3

High-throughput

0.479

High

1397891

KLH15
Kelch-like protein 15

1

14

High-throughput

0.479

High

1400467

BTBD9
BTB/POZ domain-containing protein 9

1

18

High-throughput

0.479

High

1402270

WRIP1
ATPase WRNIP1

1

8

High-throughput

0.479

High

1412384

BTBDA
BTB/POZ domain-containing protein 10

1

2

High-throughput

0.479

High

1416386

CAR10
Caspase recruitment domain-containing protein 10

1

7

High-throughput

0.479

High

1416438

SSBP3
Single-stranded DNA-binding protein 3

1

4

High-throughput

0.479

High

1416616

BTBD2
BTB/POZ domain-containing protein 2

1

16

High-throughput

0.479

High

1419964

REN3B
Regulator of nonsense transcripts 3B

1

3

High-throughput

0.479

High

1421075

ZY11B
Protein zyg-11 homolog B

1

1

High-throughput

0.479

High

1421280

KLHL4
Kelch-like protein 4

1

14

High-throughput

0.479

High

1429771

BTBD1
BTB/POZ domain-containing protein 1

1

17

High-throughput

0.479

High

1430060

KLH25
Kelch-like protein 25

1

11

High-throughput

0.479

High

1433678

FA83D
Protein FAM83D

1

3

High-throughput

0.479

High

1437282

ELP3
Elongator complex protein 3

1

1

High-throughput

0.479

High

1437762

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

9

High-throughput

0.479

High

1449357

SYFB
Phenylalanine--tRNA ligase beta subunit

1

2

High-throughput

0.479

High

1452302

TBA8
Tubulin alpha-8 chain

1

14

High-throughput

0.479

High

1454627

KLHL9
Kelch-like protein 9

1

14

High-throughput

0.479

High

1454752

KLH13
Kelch-like protein 13

1

14

High-throughput

0.479

High

1458804

PEF1
Peflin

1

12

Small-scale

0.479

High

1459090

FXL17
F-box/LRR-repeat protein 17

1

2

High-throughput

0.479

High

1460226

DACH1
Dachshund homolog 1

1

1

High-throughput

0.479

High

1460428

HERC5
E3 ISG15--protein ligase HERC5

1

9

Small-scale

0.479

High

1490566

COF2
Cofilin-2

1

7

High-throughput

0.479

High

1490759

NISCH
Nischarin

1

10

High-throughput

0.479

High

1491246

FBX7
F-box only protein 7

1

1

High-throughput

0.479

High

1491323

HBS1L
HBS1-like protein

1

9

High-throughput

0.479

High

1491345

TLN1
Talin-1

1

13

Small-scale

0.479

High

1491466

IPP
Actin-binding protein IPP

1

13

High-throughput

0.479

High

1491468

MAFB
Transcription factor MafB

1

5

High-throughput

0.479

High

1491469

SNCAP
Synphilin-1

1

9

Small-scale

0.479

High

75765

B3KW44
tRNA N(3)-cytidine methyltransferase

1

0

High-throughput

0.458

High

322631

FBX21
F-box only protein 21

1

0

High-throughput

0.458

High

769612

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

1024249

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

1179204

CTC1
CST complex subunit CTC1

1

0

High-throughput

0.458

High

1280196

FBX33
F-box only protein 33

1

0

High-throughput

0.458

High

1380697

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1439151

ZSWM6
Zinc finger SWIM domain-containing protein 6

1

0

High-throughput

0.458

High

584168

FOSL2
Fos-related antigen 2

1

7

High-throughput

0.445

High

1041393

CAV1
Caveolin-1

1

1

High-throughput

0.437

High

1200030

KLH26
Kelch-like protein 26

1

13

High-throughput

0.437

High

1281680

ZER1
Protein zer-1 homolog

1

1

High-throughput

0.437

High

1315610

MICU2
Calcium uptake protein 2, mitochondrial

1

6

High-throughput

0.437

High

1385790

NSUN4
5-cytosine rRNA methyltransferase NSUN4

1

7

High-throughput

0.437

High

1387777

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

1

High-throughput

0.437

High

1401306

SNX18
Sorting nexin-18

1

10

High-throughput

0.437

High

1409626

NIPS1
Protein NipSnap homolog 1

1

1

High-throughput

0.437

High

1155213

EREP1
Endosomal transmembrane epsin interactor 1

1

2

Small-scale

0.417

High

1398032

MF14A
Hippocampus abundant transcript 1 protein

1

1

High-throughput

0.407

High

1208290

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

3

0

High-throughput

0.347

High

1316802

SELH
Selenoprotein H

3

0

High-throughput

0.347

High

1400851

TEFM
Transcription elongation factor, mitochondrial

3

0

High-throughput

0.347

High

933251

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.279

Low

516138

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025