HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PDIA4 (P13667)
Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)
Gene: PDIA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 24244333
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0034976 - response to endoplasmic reticulum stress
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 645
+	Hs
		242221 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		DJC10_HUMAN (54-285): 1.12e-46: 178: 21.25
+	Hs
		240508 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PDIA1_HUMAN (4-164): 1.71e-31: 130: 27.27
+	Hs
		240847 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PDIA3_HUMAN (5-188): 1.81e-29: 124: 27.04
+	Hs
		242302 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		TXND5_HUMAN (176-391): 3.68e-29: 122: 22.18
+	Hs
		241730 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PDIA6_HUMAN (522-642): 7.36e-29: 121: 28.10
+	Hs
		335148 ARI2_HUMAN (222-464): 9.66e-64: 215: 20.82		DJC10_HUMAN (54-285): 1.12e-46: 178: 21.25
+	At
		1167945 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PDI14_ARATH (38-546): 3.29e-45: 171: 17.47