HitPredict

Interactor 1: H2B1K (O60814)
Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1)
Gene: H2BC12

Interactor 2: TOP2B (Q02880)
DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)
Gene: TOP2B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34349018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 1626
+	Hs
		918302 H2B1C_HUMAN (1-126): 1.07e-53: 166: 99.21		TOP2B_HUMAN (1-1626): 0: 1792: 100.00
+	Hs
		973343 H2B2E_HUMAN (1-126): 5.55e-54: 166: 98.41		TOP2B_HUMAN (1-1626): 0: 1792: 100.00
+	Hs
		241433 H2B1K_HUMAN (1-126): 1.2e-53: 166: 100.00		TOP2A_HUMAN (33-1617): 0: 1625: 66.50
+	Hs
		420797 H2B1J_HUMAN (1-126): 6.13e-54: 166: 99.21		TOP2A_HUMAN (33-1617): 0: 1625: 66.50
+	Hs
		508918 H2B1C_HUMAN (1-126): 1.07e-53: 166: 99.21		TOP2A_HUMAN (33-1617): 0: 1625: 66.50
+	Hs
		509018 H2B2E_HUMAN (1-126): 5.55e-54: 166: 98.41		TOP2A_HUMAN (33-1617): 0: 1625: 66.50
+	Hs
		509080 H2B1H_HUMAN (1-126): 5.43e-54: 166: 98.41		TOP2A_HUMAN (33-1617): 0: 1625: 66.50
+	Hs
		508891 H2B1D_HUMAN (1-126): 3.17e-53: 164: 98.41		TOP2A_HUMAN (33-1617): 0: 1625: 66.50
+	Hs
		509103 H2B1L_HUMAN (1-126): 2.18e-52: 163: 97.62		TOP2A_HUMAN (33-1617): 0: 1625: 66.50
+	Sc
		355737 H2B2_YEAST (3-125): 7.25e-37: 123: 70.73		TOP2_YEAST (44-1445): 0: 1260: 41.29
+	Sc
		355300 H2B1_YEAST (3-125): 3e-36: 122: 70.73		TOP2_YEAST (44-1445): 0: 1260: 41.29
+	Hs
		764618 H2B1C_HUMAN (1-126): 1.07e-53: 166: 99.21		CUX1_HUMAN (894-1593): 4.4e-40: 165: 11.84
+	Hs
		707541 H2B1B_HUMAN (1-126): 1.52e-53: 165: 96.83		CUX1_HUMAN (894-1593): 4.4e-40: 165: 11.84