HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: RBM14 (Q96PK6)
RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein)
Gene: RBM14

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	32929329, 35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016607 - nuclear speck GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 669
+	Hs
		242797 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		RBM4_HUMAN (1-349): 7.23e-60: 206: 27.22
+	Hs
		240604 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PABP1_HUMAN (3-555): 1.63e-35: 144: 14.36
+	Hs
		242547 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PABP5_HUMAN (3-169): 2.17e-17: 86.5: 26.53
+	Hs
		241644 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		HNRPD_HUMAN (76-161): 1.03e-15: 81.2: 22.45
+	Hs
		241583 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PABP4_HUMAN (71-151): 5.62e-10: 64.6: 23.60
+	Hs
		241871 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PAP1L_HUMAN (71-151): 1.61e-09: 63.1: 20.23
+	Hs
		242907 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PABP3_HUMAN (71-151): 1.86e-09: 62.7: 21.35
+	Hs
		1399721 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		RBM14_HUMAN (1-669): 1.6e-66: 232: 100.00
+	Hs
		550453 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		PABP1_HUMAN (3-555): 1.63e-35: 144: 14.36
+	Hs
		334982 ARI2_HUMAN (222-464): 9.66e-64: 215: 20.82		PABP1_HUMAN (3-555): 1.63e-35: 144: 14.36
+	Hs
		1102012 CUL9_HUMAN (30-463): 4.64e-78: 267: 18.81		PABP4_HUMAN (71-151): 5.62e-10: 64.6: 23.60
+	Hs
		1120324 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		HNRPD_HUMAN (76-161): 1.03e-15: 81.2: 22.45
+	Hs
		335124 ARI2_HUMAN (222-464): 9.66e-64: 215: 20.82		HNRPD_HUMAN (76-161): 1.03e-15: 81.2: 22.45
+	Hs
		1102083 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		PABP4_HUMAN (71-151): 5.62e-10: 64.6: 23.60
+	At
		198413 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PABP4_ARATH (3-491): 3.26e-33: 137: 14.66
+	At
		1020252 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		RS40_ARATH (3-316): 1.63e-19: 92.7: 24.23
+	At
		1048479 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		CP31A_ARATH (2-150): 3.54e-18: 88.1: 28.57