HitPredict

Interactor 1: DIAP2 (O60879)
Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2)
Gene: DIAPH2

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Drf_FH3~Ras, Drf_GBD~Ras
Common GO terms	GO:0005829 - cytosol GO:0030041 - actin filament polymerization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1101 Hs			1 192
+	Hs
		925658 DIAP3_HUMAN (13-1093): 0: 886: 56.56		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		564704 DIAP3_HUMAN (13-1093): 0: 886: 56.56		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		545645 DIAP3_HUMAN (13-1093): 0: 886: 56.56		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		1330940 DIAP3_HUMAN (13-1093): 0: 886: 56.56		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		892621 DIAP3_HUMAN (13-1093): 0: 886: 56.56		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		951386 DIAP3_HUMAN (13-1093): 0: 886: 56.56		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		894489 DIAP3_HUMAN (13-1093): 0: 886: 56.56		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		900958 DIAP3_HUMAN (13-1093): 0: 886: 56.56		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436532 DIAP3_HUMAN (13-1093): 0: 886: 56.56		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		925531 FMNL2_HUMAN (91-1091): 0: 651: 22.60		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		545484 FMNL3_HUMAN (91-1091): 0: 642: 21.57		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		894328 FMNL2_HUMAN (91-1091): 0: 651: 22.60		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		900815 FMNL2_HUMAN (91-1091): 0: 651: 22.60		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		894190 FMNL3_HUMAN (91-1091): 0: 642: 21.57		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		436466 FMNL2_HUMAN (91-1091): 0: 651: 22.60		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		900661 FMNL3_HUMAN (91-1091): 0: 642: 21.57		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Dd
		710114 FORH_DICDI (72-1074): 0: 606: 20.76		RAC1A_DICDI (1-192): 5.63e-82: 243: 81.96
+	Dm
		776921 FRL_DROME (192-1093): 0: 586: 21.41		RAC1_DROME (1-192): 8.65e-83: 245: 91.67
+	Dm
		776944 FRL_DROME (192-1093): 0: 586: 21.41		CDC42_DROME (1-192): 2.41e-77: 231: 70.83
+	Hs
		314838 FMNL1_HUMAN (30-1078): 0: 563: 19.45		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19