Protein: RPB2
DNA-directed RNA polymerase II subunit RPB2 (RNA polymerase II subunit 2) (EC 2.7.7.6) (B150) (DNA-directed RNA polymerase II 140 kDa polypeptide)

Gene: RPB2
Organism: Saccharomyces cerevisiae S288C
Interactions: 214
UniProt ID: P08518

Gene Ontology (top 5):
GO:0001172 - RNA-templated transcription
GO:0003677 - DNA binding
GO:0003729 - mRNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

470449

RPB3
DNA-directed RNA polymerase II subunit RPB3

26

17

Small-scale

0.991

High

401824

RPB1
DNA-directed RNA polymerase II subunit RPB1

19

20

Small-scale

0.987

High

470545

T2FB
Transcription initiation factor IIF subunit beta

8

2

Small-scale

0.969

High

470478

RPB9
DNA-directed RNA polymerase II subunit RPB9

8

12

Small-scale

0.969

High

470501

RPB7
DNA-directed RNA polymerase II subunit RPB7

9

11

Small-scale

0.967

High

470458

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

7

8

Small-scale

0.965

High

470456

RPB4
DNA-directed RNA polymerase II subunit RPB4

8

3

Small-scale

0.961

High

470477

SPT5
Transcription elongation factor SPT5

7

4

Small-scale

0.960

High

470461

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

5

9

Small-scale

0.924

High

470525

RPB11
DNA-directed RNA polymerase II subunit RPB11

5

9

Small-scale

0.919

High

470544

T2FA
Transcription initiation factor IIF subunit alpha

7

0

Small-scale

0.914

High

470517

PAF1
RNA polymerase II-associated protein 1

2

1

Small-scale

0.768

High

470480

TF2B
Transcription initiation factor IIB

2

5

Small-scale

0.754

High

470571

H3
Histone H3

2

4

Small-scale

0.754

High

470457

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

9

10

Small-scale

0.752

High

470459

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

7

6

Small-scale

0.742

High

470494

MCES
mRNA cap guanine-N(7) methyltransferase

2

0

High-throughput

0.736

High

470470

RNA15
mRNA 3'-end-processing protein RNA15

1

1

Small-scale

0.724

High

470551

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

6

2

Small-scale

0.721

High

470576

NOP3
Serine/arginine

2

0

Small-scale

0.716

High

470534

RTR1
RNA polymerase II subunit B1 CTD phosphatase RTR1

5

3

Small-scale

0.709

High

470502

TAF14
Transcription initiation factor TFIID subunit 14

6

0

Small-scale

0.701

High

470599

CDC73
Cell division control protein 73

4

1

Small-scale

0.692

High

470532

RSP5
E3 ubiquitin-protein ligase RSP5

4

10

Small-scale

0.692

High

470565

NRD1
Protein NRD1

1

2

Small-scale

0.691

High

470497

SPT4
Transcription elongation factor SPT4

4

1

Small-scale

0.691

High

470603

IWR1
RNA polymerase II nuclear localization protein IWR1

4

1

Small-scale

0.691

High

470600

ASR1
Alcohol-sensitive RING finger protein 1

5

0

Small-scale

0.688

High

470597

IWS1
Transcription factor SPN1

4

1

High-throughput

0.688

High

470553

GPN1
GPN-loop GTPase 1

10

13

Small-scale

0.685

High

470537

RAD26
DNA repair and recombination protein RAD26

1

3

Small-scale

0.647

High

470489

SPT16
FACT complex subunit SPT16

3

1

Small-scale

0.640

High

470441

HSP71
Heat shock protein SSA1

3

6

High-throughput

0.634

High

470455

MED14
Mediator of RNA polymerase II transcription subunit 14

3

1

Small-scale

0.633

High

470528

PCF11
Protein PCF11

2

3

Small-scale

0.629

High

470472

RAD51
DNA repair protein RAD51

2

5

High-throughput

0.621

High

419323

H2A1
Histone H2A.1

1

3

High-throughput

0.618

High

434705

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.618

High

458973

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

17

Small-scale

0.618

High

470434

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

10

High-throughput

0.618

High

470463

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

10

High-throughput

0.618

High

470506

CENPA
Histone H3-like centromeric protein CSE4

1

4

High-throughput

0.618

High

470508

ELF1
Transcription elongation factor 1

1

1

High-throughput

0.618

High

470521

MIP6
RNA-binding protein MIP6

1

1

Small-scale

0.618

High

470538

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

6

High-throughput

0.618

High

470602

SUB2
ATP-dependent RNA helicase SUB2

1

1

High-throughput

0.618

High

470518

LEO1
RNA polymerase-associated protein LEO1

1

0

Small-scale

0.614

High

470575

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

2

2

Small-scale

0.601

High

470591

RT103
Regulator of Ty1 transposition protein 103

2

10

Small-scale

0.601

High

470468

SIS1
Protein SIS1

2

3

High-throughput

0.588

High

470608

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

2

1

High-throughput

0.588

High

470564

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

2

0

Small-scale

0.588

High

454678

KAPR
cAMP-dependent protein kinase regulatory subunit

1

0

Small-scale

0.586

High

470527

NAB3
Nuclear polyadenylated RNA-binding protein 3

1

0

High-throughput

0.586

High

470579

HAP5
Transcriptional activator HAP5

1

0

High-throughput

0.586

High

470611

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.586

High

470465

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

2

0

High-throughput

0.585

High

470467

SPT6
Transcription elongation factor SPT6

2

1

High-throughput

0.584

High

470536

ATAD2
ATPase histone chaperone YTA7

2

6

Small-scale

0.584

High

470542

DSN1
Kinetochore-associated protein DSN1

2

2

High-throughput

0.584

High

470550

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

5

High-throughput

0.584

High

470572

SEN1
Helicase SEN1

2

3

Small-scale

0.584

High

470589

POB3
FACT complex subunit POB3

2

3

High-throughput

0.584

High

392038

HSP82
ATP-dependent molecular chaperone HSP82

2

4

High-throughput

0.571

High

470444

SSB1
Ribosome-associated molecular chaperone SSB1

2

6

High-throughput

0.571

High

470482

HS104
Heat shock protein 104

2

6

High-throughput

0.571

High

470479

URA7
CTP synthase 1

2

1

High-throughput

0.567

High

440816

KIN28
Serine/threonine-protein kinase KIN28

1

6

Small-scale

0.561

High

149495

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.553

High

433353

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.553

High

470617

DBP10
ATP-dependent RNA helicase DBP10

1

5

High-throughput

0.553

High

470442

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.552

High

470535

SSB2
Ribosome-associated molecular chaperone SSB2

2

6

High-throughput

0.552

High

470492

MED18
Mediator of RNA polymerase II transcription subunit 18

2

0

Small-scale

0.547

High

470588

UFO1
Ubiquitin ligase complex F-box protein UFO1

1

0

Small-scale

0.537

High

416995

VDAC1
Non-selective voltage-gated ion channel 1

1

3

High-throughput

0.536

High

440999

KAPA
cAMP-dependent protein kinase type 1

1

4

High-throughput

0.536

High

441312

KAPB
cAMP-dependent protein kinase type 2

1

4

High-throughput

0.536

High

470443

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.536

High

470481

XPO1
Exportin-1

1

4

High-throughput

0.536

High

470507

MAOM
NAD-dependent malic enzyme, mitochondrial

1

1

High-throughput

0.536

High

470512

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

2

High-throughput

0.536

High

470522

MED6
Mediator of RNA polymerase II transcription subunit 6

1

2

High-throughput

0.536

High

470547

ELP2
Elongator complex protein 2

1

2

Small-scale

0.536

High

470566

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.536

High

470583

GCN5
Histone acetyltransferase GCN5

1

8

High-throughput

0.536

High

470598

GPN3
GPN-loop GTPase 3

2

13

Small-scale

0.533

High

470491

CBS
Cystathionine beta-synthase

1

1

High-throughput

0.515

High

470526

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.513

High

470554

YMR1
Phosphoinositide 3-phosphatase

1

0

High-throughput

0.513

High

470580

GIP3
GLC7-interacting protein 3

1

0

High-throughput

0.513

High

470590

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.513

High

470452

FUS3
Mitogen-activated protein kinase FUS3

1

1

High-throughput

0.501

High

470469

RNA14
mRNA 3'-end-processing protein RNA14

1

2

Small-scale

0.501

High

470510

T2EB
Transcription initiation factor IIE subunit beta

1

1

Small-scale

0.501

High

364242

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.500

High

437866

KAPC
cAMP-dependent protein kinase type 3

1

4

High-throughput

0.500

High

470462

DBF2
Cell cycle protein kinase DBF2

1

5

High-throughput

0.500

High

470464

SAN1
Protein SAN1

1

1

High-throughput

0.500

High

470466

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

5

High-throughput

0.500

High

470485

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

4

High-throughput

0.500

High

470498

PRS6B
26S proteasome regulatory subunit 6B homolog

1

2

High-throughput

0.500

High

470505

KDX1
Serine/threonine-protein kinase KDX1

1

4

High-throughput

0.500

High

470513

CHK1
Serine/threonine-protein kinase CHK1

1

1

High-throughput

0.500

High

470567

CBK1
Serine/threonine-protein kinase CBK1

1

3

High-throughput

0.500

High

470587

KU80
ATP-dependent DNA helicase II subunit 2

1

2

High-throughput

0.500

High

470613

RAD59
DNA repair protein RAD59

1

1

High-throughput

0.500

High

470446

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

4

High-throughput

0.489

High

470515

GID4
GID complex substrate-recognition subunit 4

1

1

High-throughput

0.489

High

470520

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.489

High

470548

GCN20
Protein GCN20

1

6

High-throughput

0.489

High

470615

HSP42
Heat shock protein 42

1

2

High-throughput

0.489

High

470447

UBC5
Ubiquitin-conjugating enzyme E2-16 kDa

1

0

Small-scale

0.480

High

470509

T2EA
Transcription initiation factor IIE subunit alpha

1

0

Small-scale

0.480

High

470561

RTF1
RNA polymerase-associated protein RTF1

1

0

Small-scale

0.480

High

470605

CLP1
mRNA cleavage and polyadenylation factor CLP1

1

0

Small-scale

0.480

High

470460

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.479

High

470475

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.479

High

470493

RAD24
Checkpoint protein RAD24

1

0

High-throughput

0.479

High

470563

BUD32
EKC/KEOPS complex subunit BUD32

1

0

High-throughput

0.479

High

381798

H4
Histone H4

1

3

High-throughput

0.479

High

430741

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

3

Small-scale

0.479

High

441614

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

464524

PBS2
MAP kinase kinase PBS2

1

6

High-throughput

0.479

High

470440

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

470450

EF3A
Elongation factor 3A

1

7

High-throughput

0.479

High

470474

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

470486

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

3

High-throughput

0.479

High

470488

HOG1
Mitogen-activated protein kinase HOG1

1

2

High-throughput

0.479

High

470495

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

470496

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

470504

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

470511

GBLP
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.479

High

470519

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

470530

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.479

High

470549

BUD27
Bud site selection protein 27

1

2

High-throughput

0.479

High

470558

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

2

High-throughput

0.479

High

470569

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

470570

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

470574

MCE1
mRNA-capping enzyme subunit alpha

1

1

High-throughput

0.479

High

470582

TOM1
E3 ubiquitin-protein ligase TOM1

1

10

High-throughput

0.479

High

470585

RUVB1
RuvB-like protein 1

1

8

High-throughput

0.479

High

470586

RBA50
RNA polymerase II-associated protein RBA50

1

3

High-throughput

0.479

High

470592

RBS1
RNA-binding suppressor of PAS kinase protein 1

1

1

Small-scale

0.479

High

470594

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.479

High

470596

TFC6
Transcription factor tau 91 kDa subunit

1

2

High-throughput

0.479

High

470604

SGO1
Shugoshin

1

2

High-throughput

0.479

High

470609

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

5

High-throughput

0.479

High

470610

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.479

High

470618

RUVB2
RuvB-like protein 2

1

8

High-throughput

0.479

High

470453

HPR1
THO complex subunit HPR1

1

0

Small-scale

0.458

High

470499

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

Small-scale

0.458

High

470524

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.458

High

470531

RS26B
Small ribosomal subunit protein eS26B

1

0

High-throughput

0.458

High

470568

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

0

Small-scale

0.458

High

470573

PRP38
Pre-mRNA-splicing factor 38

1

0

High-throughput

0.458

High

470581

ESP1
Separin

1

0

High-throughput

0.458

High

470593

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

470595

PDP3
NuA3 HAT complex component PDP3

1

0

Small-scale

0.458

High

470612

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.458

High

470484

DBF20
Serine/threonine-protein kinase DBF20

1

6

High-throughput

0.457

High

394124

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.445

High

456305

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

2

High-throughput

0.445

High

470438

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

5

High-throughput

0.445

High

470448

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.445

High

470451

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

1

High-throughput

0.445

High

470473

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.445

High

470503

DEF1
RNA polymerase II degradation factor 1

1

1

High-throughput

0.445

High

470523

SSZ1
Ribosome-associated complex subunit SSZ1

1

2

High-throughput

0.445

High

470539

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

1

High-throughput

0.445

High

470541

DJP1
DnaJ-like protein 1

1

4

High-throughput

0.445

High

470557

PHB2
Prohibitin-2

1

1

High-throughput

0.445

High

470559

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

1

High-throughput

0.445

High

470560

ACS2
Acetyl-coenzyme A synthetase 2

1

1

High-throughput

0.445

High

470578

ADA2
SAGA complex subunit ADA2

1

3

High-throughput

0.445

High

383424

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

409846

RL25
Large ribosomal subunit protein uL23

1

1

Small-scale

0.437

High

435676

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

454778

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.437

High

470435

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.437

High

470436

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

470437

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

470439

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.437

High

470445

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

470471

RS2
Small ribosomal subunit protein uS5

1

4

High-throughput

0.437

High

470476

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

470500

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

470529

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

470555

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.437

High

470556

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

470577

RS15
Small ribosomal subunit protein uS19

1

4

High-throughput

0.437

High

470601

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

470606

GPN2
GPN-loop GTPase 2

1

13

High-throughput

0.437

High

470607

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

470619

RTP1
RNA polymerase II assembly factor RTP1

1

1

Small-scale

0.437

High

470483

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

High-throughput

0.426

High

470490

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

Small-scale

0.426

High

470614

MED1
Mediator of RNA polymerase II transcription subunit 1

1

0

High-throughput

0.426

High

368302

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

2

High-throughput

0.407

High

455619

GPT
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

1

0

High-throughput

0.282

High

470540

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.282

High

470562

MON1
Vacuolar fusion protein MON1

1

0

High-throughput

0.269

Low

470454

CDC42
Cell division control protein 42

1

0

High-throughput

0.261

Low

470487

CDC11
Cell division control protein 11

1

0

High-throughput

0.261

Low

470516

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.261

Low

470543

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.261

Low

470546

SKP2
F-box protein SKP2

1

0

High-throughput

0.261

Low

470616

HRT3
F-box protein HRT3

1

0

High-throughput

0.261

Low

148851

CET1
mRNA-capping enzyme subunit beta

1

0

High-throughput

0.249

Low

470514

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.249

Low

470533

BIM1
Protein BIM1

1

0

High-throughput

0.249

Low

470552

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

470584

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025