HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: SLAF7 (Q9NQ25)
SLAM family member 7 (CD2 subset 1) (CD2-like receptor-activating cytotoxic cells) (CRACC) (Membrane protein FOAP-12) (Novel Ly9) (Protein 19A) (CD antigen CD319)
Gene: SLAMF7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	19150402, 24642916
Identification Methods	peptide array, surface plasmon resonance
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002250 - adaptive immune response GO:0042267 - natural killer cell mediated cytotoxicity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 335
+	Hs
		1271567 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		SLAF7_HUMAN (1-335): 5.07e-65: 210: 100.00
+	Hs
		1030743 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		SLAF1_HUMAN (3-325): 4.68e-59: 195: 18.75
+	Hs
		454828 FGR_HUMAN (1-126): 6.18e-38: 135: 20.30		SLAF1_HUMAN (3-325): 4.68e-59: 195: 18.75
+	Hs
		523136 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		CD244_HUMAN (1-334): 1.81e-53: 181: 19.72
+	Hs
		1271565 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		CD244_HUMAN (1-334): 1.81e-53: 181: 19.72
+	Hs
		789096 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		SLAF5_HUMAN (1-335): 1.9e-50: 172: 29.10
+	Hs
		433317 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		CXAR_HUMAN (1-332): 1.7e-50: 173: 17.37
+	Hs
		433691 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		CXAR_HUMAN (1-332): 1.7e-50: 173: 17.37
+	Hs
		411818 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		SLAF6_HUMAN (9-335): 1.13e-47: 165: 27.67
+	Mm
		639452 LYN_MOUSE (1-125): 1.07e-39: 140: 19.85		FCRL5_MOUSE (77-328): 7.37e-46: 166: 16.86
+	Hs
		411561 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		CD48_HUMAN (19-242): 1.96e-47: 161: 17.78
+	Hs
		1271566 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		LY9_HUMAN (19-298): 1.41e-44: 163: 26.06
+	Hs
		523015 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		CEA21_HUMAN (31-280): 4.89e-45: 157: 18.08
+	Mm
		1322348 SHIP1_MOUSE (4-103): 9.63e-37: 133: 42.00		SLAF1_MOUSE (3-325): 6.34e-46: 161: 18.52
+	Hs
		411547 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		CD2_HUMAN (4-323): 2.41e-42: 151: 17.16
+	Hs
		434111 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		ROBO1_HUMAN (125-317): 3.99e-20: 93.4: 11.43
+	Hs
		433569 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		CD22_HUMAN (11-224): 7.17e-11: 65.2: 16.59
+	Mm
		722908 SHIP1_MOUSE (4-103): 9.63e-37: 133: 42.00		CD22_MOUSE (6-217): 8.53e-13: 71.4: 13.24
+	Hs
		523003 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		MYLK_HUMAN (138-212): 8.53e-11: 65.3: 20.24
+	Hs
		590610 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		CD22_HUMAN (11-224): 7.17e-11: 65.2: 16.59