Protein: FHL1
Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM-protein 1) (SLIM) (SLIM-1)

Gene: FHL1
Organism: Homo sapiens
Interactions: 143
UniProt ID: Q13642

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

895833

CSRP3
Cysteine and glycine-rich protein 3

1

18

High-throughput

0.698

High

1116419

PDLI3
PDZ and LIM domain protein 3

1

19

High-throughput

0.698

High

1116442

CLMN
Calmin

1

11

High-throughput

0.698

High

1116465

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

8

High-throughput

0.698

High

1116441

AJUBA
LIM domain-containing protein ajuba

1

18

High-throughput

0.691

High

1116461

PDLI7
PDZ and LIM domain protein 7

1

17

High-throughput

0.691

High

1054704

SUH
Recombining binding protein suppressor of hairless

4

1

Small-scale

0.686

High

1039943

AKA12
A-kinase anchor protein 12

3

12

High-throughput

0.674

High

1116409

HES1
Transcription factor HES-1

1

1

High-throughput

0.656

High

1116408

FHL2
Four and a half LIM domains protein 2

1

16

Small-scale

0.647

High

1027894

MYPC1
Myosin-binding protein C, slow-type

2

12

Small-scale

0.646

High

719323

MPIP3
M-phase inducer phosphatase 3

2

5

Small-scale

0.631

High

406155

MYCN
N-myc proto-oncogene protein

1

12

High-throughput

0.618

High

1102531

MTA1
Metastasis-associated protein MTA1

1

4

High-throughput

0.618

High

1116438

FERM2
Fermitin family homolog 2

1

6

Small-scale

0.618

High

1116433

TITIN
Titin

2

11

Small-scale

0.613

High

422076

A4
Amyloid-beta precursor protein

2

13

High-throughput

0.608

High

396069

ESR1
Estrogen receptor

2

16

Small-scale

0.601

High

404785

PRIO
Major prion protein

2

1

Small-scale

0.585

High

464952

SP1
Transcription factor Sp1

2

20

Small-scale

0.584

High

648821

KCNA5
Potassium voltage-gated channel subfamily A member 5

2

1

Small-scale

0.584

High

719143

MPIP1
M-phase inducer phosphatase 1

2

5

Small-scale

0.584

High

1067302

EP300
Histone acetyltransferase p300

2

8

Small-scale

0.584

High

1116455

PKHG2
Pleckstrin homology domain-containing family G member 2

2

19

Small-scale

0.584

High

1106526

SMAD4
Mothers against decapentaplegic homolog 4

1

17

Small-scale

0.578

High

1116412

SMAD2
Mothers against decapentaplegic homolog 2

1

17

Small-scale

0.578

High

354975

CHK2
Serine/threonine-protein kinase Chk2

1

5

Small-scale

0.573

High

971502

1433E
14-3-3 protein epsilon

1

4

Small-scale

0.573

High

1055802

RING1
E3 ubiquitin-protein ligase RING1

1

12

Small-scale

0.573

High

1116420

ZEP3
Transcription factor HIVEP3

1

9

Small-scale

0.573

High

529764

TAU
Microtubule-associated protein tau

2

14

High-throughput

0.571

High

873957

NRIP1
Nuclear receptor-interacting protein 1

1

0

Small-scale

0.569

High

877109

KC1D
Casein kinase I isoform delta

1

2

Small-scale

0.561

High

1014503

SMAD3
Mothers against decapentaplegic homolog 3

1

17

Small-scale

0.561

High

1116417

HIF1A
Hypoxia-inducible factor 1-alpha

1

5

Small-scale

0.561

High

1116468

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

1

Small-scale

0.561

High

1116443

SRPK1
SRSF protein kinase 1

1

5

High-throughput

0.550

High

105896

APRIO
Alternative prion protein

2

4

Small-scale

0.543

High

662224

PAX7
Paired box protein Pax-7

1

4

High-throughput

0.541

High

665973

IBP5
Insulin-like growth factor-binding protein 5

1

1

High-throughput

0.541

High

1116416

NFIL3
Nuclear factor interleukin-3-regulated protein

1

5

High-throughput

0.541

High

1116447

DOCK9
Dedicator of cytokinesis protein 9

1

4

High-throughput

0.541

High

1116462

ZBT40
Zinc finger and BTB domain-containing protein 40

1

15

High-throughput

0.541

High

349071

LATS1
Serine/threonine-protein kinase LATS1

1

4

High-throughput

0.536

High

563733

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

1116414

MK14
Mitogen-activated protein kinase 14

1

8

High-throughput

0.536

High

1116426

ZN444
Zinc finger protein 444

1

20

High-throughput

0.536

High

1116428

ZN784
Zinc finger protein 784

1

17

High-throughput

0.536

High

1116430

NEK7
Serine/threonine-protein kinase Nek7

1

4

High-throughput

0.536

High

1116450

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

8

High-throughput

0.536

High

1116452

KDM4C
Lysine-specific demethylase 4C

1

2

High-throughput

0.536

High

1116460

ZNF71
Endothelial zinc finger protein induced by tumor necrosis factor alpha

1

20

High-throughput

0.536

High

445871

ENOA
Alpha-enolase

1

0

High-throughput

0.518

High

1116418

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.513

High

280417

DEAF1
Deformed epidermal autoregulatory factor 1 homolog

1

3

High-throughput

0.508

High

285267

EED
Polycomb protein EED

1

5

High-throughput

0.508

High

1116415

DREB
Drebrin

1

8

High-throughput

0.508

High

1116421

MYOME
Myomegalin

1

8

High-throughput

0.508

High

977487

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

6

Small-scale

0.506

High

549318

SRF
Serum response factor

1

1

Small-scale

0.501

High

249342

ZIC3
Zinc finger protein ZIC 3

1

17

High-throughput

0.500

High

1116413

LAMA4
Laminin subunit alpha-4

1

2

High-throughput

0.494

High

1116451

TXNIP
Thioredoxin-interacting protein

1

0

High-throughput

0.486

High

125443

LEG9
Galectin-9

1

1

High-throughput

0.479

High

136891

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

12

High-throughput

0.479

High

241626

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.479

High

345783

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

8

High-throughput

0.479

High

363254

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

380025

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

3

High-throughput

0.479

High

385725

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

13

High-throughput

0.479

High

507946

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

7

High-throughput

0.479

High

537123

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.479

High

538956

EPB41
Protein 4.1

1

9

High-throughput

0.479

High

557287

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.479

High

558116

XRCC6
X-ray repair cross-complementing protein 6

1

2

High-throughput

0.479

High

588650

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

623336

RO52
E3 ubiquitin-protein ligase TRIM21

1

18

High-throughput

0.479

High

659466

CRCM
Colorectal mutant cancer protein

1

8

High-throughput

0.479

High

685554

U2AF2
Splicing factor U2AF 65 kDa subunit

1

5

High-throughput

0.479

High

695410

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

703581

MK01
Mitogen-activated protein kinase 1

1

7

Small-scale

0.479

High

719220

MPIP2
M-phase inducer phosphatase 2

1

5

Small-scale

0.479

High

728223

AKT1
RAC-alpha serine/threonine-protein kinase

1

5

Small-scale

0.479

High

730572

1433S
14-3-3 protein sigma

1

20

Small-scale

0.479

High

755912

MCM5
DNA replication licensing factor MCM5

1

3

High-throughput

0.479

High

791374

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

970464

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

990200

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.479

High

1032951

EWS
RNA-binding protein EWS

1

4

High-throughput

0.479

High

1095248

REST
RE1-silencing transcription factor

1

20

High-throughput

0.479

High

1096679

RFA4
Replication protein A 30 kDa subunit

1

2

High-throughput

0.479

High

1106835

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1113047

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1116407

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

2

High-throughput

0.479

High

1116410

MDC1
Mediator of DNA damage checkpoint protein 1

1

15

High-throughput

0.479

High

1116411

SF3A1
Splicing factor 3A subunit 1

1

9

High-throughput

0.479

High

1116423

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

1116424

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1116425

GOLI
E3 ubiquitin-protein ligase RNF130

1

3

High-throughput

0.479

High

1116427

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

1116429

BICD2
Protein bicaudal D homolog 2

1

10

High-throughput

0.479

High

1116434

TOPB1
DNA topoisomerase 2-binding protein 1

1

9

High-throughput

0.479

High

1116435

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

1116436

CBP
CREB-binding protein

1

11

Small-scale

0.479

High

1116439

BICD1
Protein bicaudal D homolog 1

1

9

High-throughput

0.479

High

1116440

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

1116453

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1116457

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

7

High-throughput

0.479

High

1116464

BCLF1
Bcl-2-associated transcription factor 1

1

2

Small-scale

0.479

High

163104

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.458

High

976257

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

983476

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

0

Small-scale

0.458

High

1026368

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1088656

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.458

High

1100760

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.458

High

1116446

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1116449

IMUP
Immortalization up-regulated protein

1

0

Small-scale

0.458

High

1116467

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

138491

BIN1
Myc box-dependent-interacting protein 1

1

9

High-throughput

0.457

High

599992

ZNF16
Zinc finger protein 16

1

8

Small-scale

0.457

High

273858

CNOT3
CCR4-NOT transcription complex subunit 3

1

10

High-throughput

0.445

High

429853

JUN
Transcription factor Jun

1

13

High-throughput

0.445

High

962029

RHOA
Transforming protein RhoA

1

3

High-throughput

0.445

High

1094335

CSN1
COP9 signalosome complex subunit 1

1

2

High-throughput

0.445

High

1116445

PCGF6
Polycomb group RING finger protein 6

1

7

High-throughput

0.445

High

1116459

ZN331
Zinc finger protein 331

1

20

High-throughput

0.445

High

1116466

GAB2
GRB2-associated-binding protein 2

1

14

High-throughput

0.445

High

768141

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1116422

OTUD1
OTU domain-containing protein 1

1

7

High-throughput

0.437

High

1116444

ERP44
Endoplasmic reticulum resident protein 44

1

1

High-throughput

0.437

High

1116463

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

5

High-throughput

0.437

High

954391

SNP25
Synaptosomal-associated protein 25

1

0

Small-scale

0.426

High

1063041

S20A2
Sodium-dependent phosphate transporter 2

1

0

High-throughput

0.426

High

1116432

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.426

High

1116437

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.426

High

1116448

NMNA2
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2

1

0

High-throughput

0.426

High

1116458

S40A1
Ferroportin

1

0

High-throughput

0.426

High

1116469

TX264
Testis-expressed protein 264

1

0

High-throughput

0.426

High

933174

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.279

Low

653302

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

1116431

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

0

High-throughput

0.232

Low

1116454

TM231
Transmembrane protein 231

1

0

High-throughput

0.232

Low

1116456

MANS1
MANSC domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025