HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35509820
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH3_1~ubiquitin, SH3_9~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0006979 - response to oxidative stress GO:0017124 - SH3 domain binding GO:0043524 - negative regulation of neuron apoptotic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 639
+	Hs
		241338 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		GRB2_HUMAN (2-168): 2.29e-41: 151: 18.06
+	Hs
		242050 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		DNMBP_HUMAN (1-633): 9.22e-34: 140: 14.11
+	Hs
		241653 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		ARHG7_HUMAN (159-362): 6.21e-12: 70.7: 20.77
+	Hs
		242385 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		SH3R3_HUMAN (42-163): 1.13e-09: 63.7: 29.03
+	Hs
		507150 UBB_HUMAN (1-234): 4.43e-61: 200: 17.92		GRB2_HUMAN (2-168): 2.29e-41: 151: 18.06
+	Dm
		53887 LUBEL_DROME (55-453): 7.47e-65: 229: 16.47		A1Z866_DROME (6-165): 2.1e-28: 122: 24.59
+	Dm
		1286065 LUBEL_DROME (55-453): 7.47e-65: 229: 16.47		Q86P80_DROME (6-165): 3.42e-28: 121: 24.59