Protein: ARHG7
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)

Gene: ARHG7, ARHGEF7
Organism: Homo sapiens
Interactions: 128
UniProt ID: Q14155

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1096429

PAK1
Serine/threonine-protein kinase PAK 1

19

16

Small-scale

0.989

High

1121998

GIT1
ARF GTPase-activating protein GIT1

14

20

Small-scale

0.983

High

1097189

PAK2
Serine/threonine-protein kinase PAK 2

7

16

Small-scale

0.970

High

1121947

GIT2
ARF GTPase-activating protein GIT2

7

20

Small-scale

0.966

High

1121949

ARHG6
Rho guanine nucleotide exchange factor 6

7

15

Small-scale

0.964

High

1121946

SCRIB
Protein scribble homolog

8

4

Small-scale

0.964

High

988358

RAC1
Ras-related C3 botulinum toxin substrate 1

6

20

Small-scale

0.939

High

955156

CDC42
Cell division control protein 42 homolog

5

20

Small-scale

0.930

High

222080

NCK2
Cytoplasmic protein NCK2

5

19

High-throughput

0.925

High

878455

PAXI
Paxillin

4

11

High-throughput

0.881

High

593993

NCK1
SH2/SH3 adapter protein NCK1

4

20

High-throughput

0.875

High

253950

LPXN
Leupaxin

3

11

High-throughput

0.855

High

1121990

SPN90
NCK-interacting protein with SH3 domain

3

3

High-throughput

0.855

High

363274

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.843

High

1121977

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

2

16

Small-scale

0.843

High

1121955

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

3

Small-scale

0.840

High

1121995

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

2

17

Small-scale

0.815

High

1121953

KCC4
Calcium/calmodulin-dependent protein kinase type IV

2

5

High-throughput

0.811

High

297102

PAK3
Serine/threonine-protein kinase PAK 3

2

16

Small-scale

0.793

High

258599

SH21A
SH2 domain-containing protein 1A

2

20

Small-scale

0.781

High

167509

TX1B3
Tax1-binding protein 3

2

12

High-throughput

0.776

High

1121951

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

2

8

High-throughput

0.776

High

1121973

SNX27
Sorting nexin-27

2

18

Small-scale

0.754

High

1122000

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

1

16

Small-scale

0.740

High

651322

CBL
E3 ubiquitin-protein ligase CBL

5

20

Small-scale

0.724

High

966303

1433G
14-3-3 protein gamma

5

20

High-throughput

0.712

High

1121997

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

10

High-throughput

0.691

High

1121974

ERBIN
Erbin

1

2

Small-scale

0.681

High

1121971

ITCH
E3 ubiquitin-protein ligase Itchy homolog

3

3

Small-scale

0.680

High

1121945

ARHG7
Rho guanine nucleotide exchange factor 7

1

13

Small-scale

0.680

High

1049281

1433F
14-3-3 protein eta

3

20

High-throughput

0.662

High

329062

KLHL2
Kelch-like protein 2

3

6

Small-scale

0.656

High

424658

KPCG
Protein kinase C gamma type

1

9

Small-scale

0.647

High

1121963

SRGP1
SLIT-ROBO Rho GTPase-activating protein 1

1

10

Small-scale

0.646

High

1121954

INAVA
Innate immunity activator protein

3

0

High-throughput

0.634

High

427895

ICAM1
Intercellular adhesion molecule 1

2

3

High-throughput

0.628

High

992171

SKP1
S-phase kinase-associated protein 1

2

2

High-throughput

0.628

High

1121984

SYNCI
Syncoilin

2

7

High-throughput

0.628

High

1121987

EXOC1
Exocyst complex component 1

2

2

High-throughput

0.628

High

1108534

TBB3
Tubulin beta-3 chain

1

5

High-throughput

0.621

High

168689

CSKP
Peripheral plasma membrane protein CASK

1

8

Small-scale

0.618

High

299546

TRIO
Triple functional domain protein

1

17

High-throughput

0.618

High

349076

LATS1
Serine/threonine-protein kinase LATS1

1

8

Small-scale

0.618

High

411911

NTRK1
High affinity nerve growth factor receptor

1

18

High-throughput

0.618

High

581039

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

601284

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

711349

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.618

High

953440

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

987629

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

1121950

PLEC
Plectin

1

12

High-throughput

0.618

High

1121952

ZYX
Zyxin

1

10

High-throughput

0.618

High

1121959

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.618

High

1121961

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1121968

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.618

High

1121972

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

1121979

KPCD2
Serine/threonine-protein kinase D2

1

9

High-throughput

0.618

High

1121983

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1121985

MED4
Mediator of RNA polymerase II transcription subunit 4

3

2

High-throughput

0.609

High

1121988

FBX28
F-box only protein 28

3

1

High-throughput

0.604

High

261801

PFD1
Prefoldin subunit 1

2

1

High-throughput

0.601

High

1097934

CBLB
E3 ubiquitin-protein ligase CBL-B

2

20

Small-scale

0.596

High

408063

TBB4A
Tubulin beta-4A chain

1

5

High-throughput

0.590

High

529779

TAU
Microtubule-associated protein tau

2

5

High-throughput

0.571

High

701026

PSB6
Proteasome subunit beta type-6

2

3

High-throughput

0.571

High

973913

RUXF
Small nuclear ribonucleoprotein F

2

3

High-throughput

0.571

High

1121958

TM154
Transmembrane protein 154

2

1

High-throughput

0.549

High

893862

MEOX2
Homeobox protein MOX-2

1

0

High-throughput

0.549

High

1121964

KAISO
Transcriptional regulator Kaiso

2

0

High-throughput

0.547

High

415561

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.541

High

899897

FXR1
RNA-binding protein FXR1

1

5

High-throughput

0.541

High

900323

FXR2
RNA-binding protein FXR2

1

5

High-throughput

0.541

High

184059

ACOX3
Peroxisomal acyl-coenzyme A oxidase 3

1

1

High-throughput

0.536

High

971514

1433E
14-3-3 protein epsilon

1

3

High-throughput

0.536

High

1121969

REPS1
RalBP1-associated Eps domain-containing protein 1

1

17

High-throughput

0.536

High

1121986

KLHL1
Kelch-like protein 1

1

5

High-throughput

0.536

High

833624

NAA10
N-alpha-acetyltransferase 10

1

1

Small-scale

0.515

High

539602

PYGM
Glycogen phosphorylase, muscle form

1

0

High-throughput

0.513

High

709121

TPP2
Tripeptidyl-peptidase 2

1

0

High-throughput

0.513

High

911243

IMA5
Importin subunit alpha-5

1

0

High-throughput

0.513

High

1121962

CENPQ
Centromere protein Q

1

0

High-throughput

0.513

High

1121992

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.513

High

1121993

TPC2L
Trafficking protein particle complex subunit 2-like protein

1

0

High-throughput

0.513

High

1121994

DNPEP
Aspartyl aminopeptidase

1

0

High-throughput

0.513

High

1121996

TPPC4
Trafficking protein particle complex subunit 4

1

0

High-throughput

0.513

High

1105799

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

7

Small-scale

0.512

High

884825

PPM1F
Protein phosphatase 1F

1

2

Small-scale

0.501

High

1121966

PPM1E
Protein phosphatase 1E

1

2

Small-scale

0.501

High

717807

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

1

Small-scale

0.500

High

1121980

CD244
Natural killer cell receptor 2B4

1

2

Small-scale

0.500

High

1121978

TMG4
Transmembrane gamma-carboxyglutamic acid protein 4

1

2

Small-scale

0.489

High

651078

RFX1
MHC class II regulatory factor RFX1

1

1

High-throughput

0.489

High

1122003

NOX1
NADPH oxidase 1

1

0

Small-scale

0.480

High

241653

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

252451

DIAP1
Protein diaphanous homolog 1

1

1

High-throughput

0.479

High

299188

FLOT1
Flotillin-1

1

6

High-throughput

0.479

High

573955

MYL6B
Myosin light chain 6B

1

2

High-throughput

0.479

High

830717

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

904701

MECP2
Methyl-CpG-binding protein 2

1

6

High-throughput

0.479

High

1014509

SMAD3
Mothers against decapentaplegic homolog 3

1

2

Small-scale

0.479

High

1121948

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1121965

XRN1
5'-3' exoribonuclease 1

1

2

High-throughput

0.479

High

1121967

HDAC2
Histone deacetylase 2

1

4

High-throughput

0.479

High

1121981

KLHL4
Kelch-like protein 4

1

6

High-throughput

0.479

High

1121991

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

822661

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.460

High

283244

ERLN1
Erlin-1

1

0

High-throughput

0.458

High

704746

ERCC5
DNA excision repair protein ERCC-5

1

0

High-throughput

0.458

High

1005321

IGBP1
Immunoglobulin-binding protein 1

1

0

Small-scale

0.458

High

1121999

DTNA
Dystrobrevin alpha

1

0

High-throughput

0.458

High

1122001

PCDGL
Protocadherin gamma-C4

1

0

High-throughput

0.458

High

690993

1433T
14-3-3 protein theta

1

20

High-throughput

0.445

High

729825

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.445

High

1121975

CK5P2
CDK5 regulatory subunit-associated protein 2

1

15

High-throughput

0.445

High

105918

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

1121956

MUC17
Mucin-17

1

1

High-throughput

0.437

High

1121976

IWS1
Protein IWS1 homolog

1

3

High-throughput

0.437

High

1121989

BICRA
BRD4-interacting chromatin-remodeling complex-associated protein

1

4

High-throughput

0.437

High

49162

POTB3
POTE ankyrin domain family member B3

1

13

High-throughput

0.407

High

94309

D6R9G5
Kelch like family member 2

1

7

High-throughput

0.407

High

756188

MCM7
DNA replication licensing factor MCM7

1

6

Small-scale

0.407

High

1121960

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

2

High-throughput

0.407

High

1122002

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

2

0

High-throughput

0.298

High

133506

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.279

Low

211640

ZNHI1
Zinc finger HIT domain-containing protein 1

1

0

High-throughput

0.279

Low

1121982

ADSSP
Adipose-secreted signaling protein

1

0

High-throughput

0.279

Low

1121957

JHY
Jhy protein homolog

1

0

High-throughput

0.249

Low

1121970

CERS2
Ceramide synthase 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025