Interactor 1: RAMP1 (O60894)
Receptor activity-modifying protein 1 (Calcitonin-receptor-like receptor activity-modifying protein 1) (CRLR activity-modifying protein 1)
Gene: RAMP1
Interactor 2: CALRL (Q16602)
Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
Gene: CALCRL
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.971 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 12684503, 11535606, 14722252, 11847213, 12574158, 9620797, 12234182, 20826335, 33602864 |
| Identification Methods | affinity chromatography technology, pull down, x-ray crystallography, molecular sieving, electron microscopy 3D single particle reconstruction |
| Interaction Type | physical association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | 7tm_2~RAMP, HRM~RAMP |
| Common GO terms | GO:0001525 - angiogenesis GO:0001635 - calcitonin gene-related peptide receptor activity GO:0005886 - plasma membrane GO:0006816 - calcium ion transport GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway and 4 others more... |
| Homologous interactions | 3 |
Homologous interactions
Color coding for hit scores 
|
|
|||||||||||||
| + | Rn |   |
|
|||||||||||
| + | Hs |  |
|
|||||||||||
| + | Hs | |
|
|||||||||||
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
