HitPredict

Interactor 1: CATL2 (O60911)
Cathepsin L2 (EC 3.4.22.43) (Cathepsin U) (Cathepsin V)
Gene: CTSV

Interactor 2: KNG1 (P01042)
Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor]
Gene: KNG1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cystatin~Peptidase_C1
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 644
+	Hs
		345171 CATL1_HUMAN (1-334): 1.18e-166: 469: 76.95		KNG1_HUMAN (1-644): 0: 924: 100.00
+	Hs
		345173 CATH_HUMAN (28-333): 3.7e-128: 371: 40.13		KNG1_HUMAN (1-644): 0: 924: 100.00
+	Hs
		245770 CATL2_HUMAN (1-334): 6.17e-171: 479: 100.00		CYTN_HUMAN (256-371): 5.89e-46: 161: 26.27
+	Hs
		245769 CATL2_HUMAN (1-334): 6.17e-171: 479: 100.00		CYTC_HUMAN (250-374): 6.49e-45: 158: 23.02
+	Hs
		344922 CATL1_HUMAN (1-334): 1.18e-166: 469: 76.95		CYTN_HUMAN (256-371): 5.89e-46: 161: 26.27
+	Hs
		344815 CATL1_HUMAN (1-334): 1.18e-166: 469: 76.95		CYTC_HUMAN (250-374): 6.49e-45: 158: 23.02
+	Hs
		283668 CATL1_HUMAN (1-334): 1.18e-166: 469: 76.95		CYTF_HUMAN (244-371): 9.77e-38: 138: 27.54
+	Hs
		245811 CATL2_HUMAN (1-334): 6.17e-171: 479: 100.00		CYTM_HUMAN (230-368): 1.79e-33: 127: 25.00
+	Hs
		429900 CATL1_HUMAN (1-334): 1.18e-166: 469: 76.95		CYTM_HUMAN (230-368): 1.79e-33: 127: 25.00
+	Hs
		637215 CATS_HUMAN (7-334): 3.45e-140: 401: 49.85		CYTD_HUMAN (247-371): 5.73e-39: 142: 21.88
+	Hs
		344926 CATH_HUMAN (28-333): 3.7e-128: 371: 40.13		CYTN_HUMAN (256-371): 5.89e-46: 161: 26.27
+	Hs
		344817 CATH_HUMAN (28-333): 3.7e-128: 371: 40.13		CYTC_HUMAN (250-374): 6.49e-45: 158: 23.02
+	Hs
		453952 CATH_HUMAN (28-333): 3.7e-128: 371: 40.13		CYTD_HUMAN (247-371): 5.73e-39: 142: 21.88