HitPredict

Interactor 1: PP1RB (O60927)
E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Hemochromatosis candidate gene V protein) (HCG V) (Protein phosphatase 1 regulatory subunit 11) (Protein phosphatase inhibitor 3)
Gene: PPP1R11

Interactor 2: PP1A (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: PPP1CA

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.751

Property	Details
Experiments	26186194, 27880917, 28514442, 27173435, 28330616, 29669786, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008157 - protein phosphatase 1 binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 330
+	Mm
		906322 PP1RB_MOUSE (1-99): 1.56e-29: 105: 84.62		PP1A_MOUSE (1-330): 0: 614: 99.70
+	Mm
		60456 A5A4Y9_MOUSE (1-99): 1.08e-28: 102: 85.58		PP1A_MOUSE (1-330): 0: 614: 99.70
+	Hs
		246074 PP1RB_HUMAN (1-103): 3.39e-35: 119: 100.00		PP1G_HUMAN (1-330): 0: 579: 90.66
+	Dm
		819234 Q9VRC5_DROME (2-100): 1.06e-34: 121: 38.00		PP11_DROME (4-330): 0: 573: 87.77
+	Hs
		246078 PP1RB_HUMAN (1-103): 3.39e-35: 119: 100.00		PP1B_HUMAN (1-330): 0: 568: 87.88
+	Dm
		524654 Q9VMI2_DROME (3-125): 3.89e-36: 122: 35.34		PP12_DROME (7-304): 0: 553: 93.29
+	Dm
		524658 Q9VRC5_DROME (2-100): 1.06e-34: 121: 38.00		PP12_DROME (7-304): 0: 553: 93.29
+	Dm
		819322 Q9VRC5_DROME (2-100): 1.06e-34: 121: 38.00		PP1B_DROME (6-326): 0: 551: 83.49
+	Dm
		984199 Q9VRC5_DROME (2-100): 1.06e-34: 121: 38.00		PP13_DROME (5-304): 0: 550: 91.67
+	Sp
		145041 YPI1_SCHPO (8-72): 6.41e-21: 82.6: 40.91		PP11_SCHPO (6-329): 0: 557: 82.41
+	At
		819351 INH3_ARATH (1-89): 2.76e-24: 91: 32.58		PP13_ARATH (4-326): 0: 548: 71.52
+	At
		819352 INH3_ARATH (1-89): 2.76e-24: 91: 32.58		PP14_ARATH (9-304): 0: 547: 79.05
+	At
		819359 INH3_ARATH (1-89): 2.76e-24: 91: 32.58		PP16_ARATH (9-329): 0: 544: 73.52
+	At
		819350 INH3_ARATH (1-89): 2.76e-24: 91: 32.58		PP12_ARATH (2-302): 0: 540: 78.48
+	At
		673655 INH3_ARATH (1-89): 2.76e-24: 91: 32.58		PP11_ARATH (4-304): 0: 537: 77.23
+	Pf
		1212834 Q8IJ88_PLAF7 (14-97): 3.35e-18: 76: 30.21		Q8ILV1_PLAF7 (6-304): 0: 551: 84.62
+	At
		819358 INH3_ARATH (1-89): 2.76e-24: 91: 32.58		PP15_ARATH (2-306): 0: 525: 76.47
+	At
		287759 INH3_ARATH (1-89): 2.76e-24: 91: 32.58		PP17_ARATH (4-328): 0: 524: 72.31
+	At
		1248172 INH3_ARATH (1-89): 2.76e-24: 91: 32.58		PP19_ARATH (1-300): 0: 522: 73.03
+	At
		287765 INH3_ARATH (1-89): 2.76e-24: 91: 32.58		PP18_ARATH (5-300): 0: 521: 73.99