Protein: HELZ2
3'-5' exoribonuclease HELZ2 (EC 3.1.13.1) (ATP-dependent RNA helicase PRIC285) (EC 3.6.4.13) (Helicase with zinc finger 2, transcriptional coactivator) (Helicase with zinc finger domain 2) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein)

Gene: HELZ2
Organism: Homo sapiens
Interactions: 67
UniProt ID: Q9BYK8

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003713 - transcription coactivator activity
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1063859

LG3BP
Galectin-3-binding protein

2

4

High-throughput

0.628

High

1230898

Z324B
Zinc finger protein 324B

2

0

High-throughput

0.602

High

860929

RS10
Small ribosomal subunit protein eS10

2

7

High-throughput

0.601

High

1233942

Q6ICH2
single-stranded DNA cytosine deaminase

2

11

High-throughput

0.584

High

391447

FRIL
Ferritin light chain

2

0

High-throughput

0.576

High

1418783

CCG5
Voltage-dependent calcium channel gamma-5 subunit

2

1

High-throughput

0.574

High

396876

ESR1
Estrogen receptor

2

11

High-throughput

0.571

High

765858

BMI1
Polycomb complex protein BMI-1

2

8

High-throughput

0.571

High

1227399

A16L1
Autophagy-related protein 16-1

2

14

High-throughput

0.571

High

239196

ZNRD2
Protein ZNRD2

1

1

High-throughput

0.536

High

502522

H2A1
Histone H2A type 1

1

6

High-throughput

0.536

High

521917

H14
Histone H1.4

1

8

High-throughput

0.536

High

658382

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.536

High

832796

BCL6
B-cell lymphoma 6 protein

1

1

Small-scale

0.536

High

970086

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

1009314

PRR3
Proline-rich protein 3

1

2

High-throughput

0.536

High

1124534

MAP7
Ensconsin

1

9

High-throughput

0.536

High

1148782

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

20

High-throughput

0.536

High

1151192

OASL
2'-5'-oligoadenylate synthase-like protein

1

3

High-throughput

0.536

High

1387885

PABP5
Polyadenylate-binding protein 5

1

10

High-throughput

0.536

High

1409830

RBM4B
RNA-binding protein 4B

1

18

High-throughput

0.536

High

1418784

PURG
Purine-rich element-binding protein gamma

1

3

High-throughput

0.536

High

1418785

ABT1
Activator of basal transcription 1

1

3

High-throughput

0.536

High

1134712

NUMA1
Nuclear mitotic apparatus protein 1

1

5

High-throughput

0.515

High

1392740

ZN764
Zinc finger protein 764

1

0

High-throughput

0.513

High

1418786

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

0

High-throughput

0.513

High

1060633

PPARA
Peroxisome proliferator-activated receptor alpha

1

12

Small-scale

0.501

High

848714

MAGA9
Melanoma-associated antigen 9

1

2

High-throughput

0.489

High

373076

MYC
Myc proto-oncogene protein

1

11

Small-scale

0.479

High

401438

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

425620

ISG15
Ubiquitin-like protein ISG15

1

4

High-throughput

0.479

High

872715

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.479

High

905109

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

1101012

G3BP1
Ras GTPase-activating protein-binding protein 1

1

11

High-throughput

0.479

High

1140800

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

1155729

EZH2
Histone-lysine N-methyltransferase EZH2

1

7

High-throughput

0.479

High

1161649

IF16
Gamma-interferon-inducible protein 16

1

10

High-throughput

0.479

High

1280476

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

Small-scale

0.479

High

1281606

SLN11
Schlafen family member 11

1

3

High-throughput

0.479

High

1330923

CGAS
Cyclic GMP-AMP synthase

1

2

High-throughput

0.479

High

1357547

DCAF4
DDB1- and CUL4-associated factor 4

1

3

High-throughput

0.479

High

1367199

ESR2
Estrogen receptor beta

1

11

High-throughput

0.479

High

1368099

HDAC2
Histone deacetylase 2

1

4

High-throughput

0.479

High

1418781

ANLN
Anillin

1

2

High-throughput

0.479

High

1418782

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.479

High

482541

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.458

High

1383400

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.458

High

58925

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.445

High

73448

B2CML4
single-stranded DNA cytosine deaminase

1

11

High-throughput

0.445

High

485390

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

9

High-throughput

0.445

High

809827

RS19
Small ribosomal subunit protein eS19

1

3

High-throughput

0.445

High

984960

RL31
Large ribosomal subunit protein eL31

1

3

High-throughput

0.445

High

1034613

AK17A
A-kinase anchor protein 17A

1

4

High-throughput

0.445

High

1037354

H11
Histone H1.1

1

8

High-throughput

0.445

High

1112160

KRR1
KRR1 small subunit processome component homolog

1

4

High-throughput

0.445

High

1140015

RRS1
Ribosome biogenesis regulatory protein homolog

1

3

High-throughput

0.445

High

1315247

CA174
UPF0688 protein C1orf174

1

1

High-throughput

0.445

High

1335380

CAMKV
CaM kinase-like vesicle-associated protein

1

1

High-throughput

0.445

High

1348844

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

1

18

High-throughput

0.445

High

1383327

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

11

High-throughput

0.445

High

1418787

YBOX2
Y-box-binding protein 2

1

11

High-throughput

0.445

High

1032862

XPC
DNA repair protein complementing XP-C cells

1

0

High-throughput

0.426

High

1157681

CRY1
Cryptochrome-1

1

0

Small-scale

0.426

High

1411542

PYM1
Partner of Y14 and mago

1

0

High-throughput

0.426

High

378298

IFN21
Interferon alpha-21

1

1

High-throughput

0.407

High

378341

IFN14
Interferon alpha-14

1

1

High-throughput

0.407

High

190478

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025