Interactor 1: NBN (O60934)
Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1)
Gene: NBN
Interactor 2: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 1.00 | 0.987 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 27590578, 12607003, 12607005, 23115235, 18678890, 30179224, 14519663, 29656893, 15201865, 20460517, 20224574, 18583988, 25064736, 19804756, 18001824 |
| Identification Methods | affinity chromatography technology, pull down, unspecified method, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification, isothermal titration calorimetry, coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | BRCT~BRCT_2, FHA~FHA |
| Common GO terms | GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035861 - site of double-strand break GO:0140463 - chromatin-protein adaptor activity GO:1990166 - protein localization to site of double-strand break |
| Homologous interactions | 2 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
