HitPredict

Interactor 1: DOK2 (O70469)
Docking protein 2 (Dok-related protein) (Dok-R) (Downstream of tyrosine kinase 2) (IL-four receptor-interacting protein) (FRIP) (p56(dok-2))
Gene: DOK2

Interactor 2: NCK1 (Q99M51)
SH2/SH3 adapter protein Nck1 (Cytoplasmic protein Nck1) (NCK adapter protein 1) (Nck-1)
Gene: NCK1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	20697350
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Mm			1 377
+	Mm
		223005 DOK2_MOUSE (1-412): 1.11e-159: 457: 100.00		NCK2_MOUSE (1-376): 3.34e-90: 278: 67.19
+	Hs
		235041 DOK2_HUMAN (4-412): 4.96e-142: 412: 74.04		NCK1_HUMAN (1-377): 2.9e-97: 295: 98.94
+	Hs
		208960 DOK2_HUMAN (4-412): 4.96e-142: 412: 74.04		NCK2_HUMAN (1-376): 7.37e-90: 277: 68.50
+	Mm
		956524 DOK1_MOUSE (6-393): 3.94e-113: 341: 34.51		NCK1_MOUSE (1-377): 8.52e-98: 297: 100.00
+	Mm
		223011 DOK1_MOUSE (6-393): 3.94e-113: 341: 34.51		NCK2_MOUSE (1-376): 3.34e-90: 278: 67.19
+	Hs
		209149 DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11		NCK2_HUMAN (1-376): 7.37e-90: 277: 68.50
+	Mm
		250949 DOK2_MOUSE (1-412): 1.11e-159: 457: 100.00		SRC_MOUSE (6-130): 5.82e-19: 90.1: 21.26
+	Mm
		250951 DOK2_MOUSE (1-412): 1.11e-159: 457: 100.00		CSK_MOUSE (4-143): 8.51e-17: 83.3: 14.38
+	Hs
		235037 DOK2_HUMAN (4-412): 4.96e-142: 412: 74.04		YES_HUMAN (6-152): 2.64e-22: 100: 19.87
+	Hs
		235036 DOK2_HUMAN (4-412): 4.96e-142: 412: 74.04		FYN_HUMAN (6-130): 3.47e-22: 99.8: 21.26
+	Hs
		235040 DOK2_HUMAN (4-412): 4.96e-142: 412: 74.04		SRC_HUMAN (6-130): 5.78e-19: 90.1: 21.26
+	Hs
		235051 DOK2_HUMAN (4-412): 4.96e-142: 412: 74.04		CSK_HUMAN (4-143): 8.06e-17: 83.7: 14.38
+	Mm
		643076 DOK1_MOUSE (6-393): 3.94e-113: 341: 34.51		P85A_MOUSE (241-376): 2.56e-22: 100: 19.57
+	Hs
		433460 DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11		YES_HUMAN (6-152): 2.64e-22: 100: 19.87
+	Hs
		454844 DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11		FGR_HUMAN (6-130): 3.16e-22: 99.8: 21.26
+	Hs
		442876 DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11		HCK_HUMAN (2-130): 1.23e-21: 98.3: 22.31
+	Hs
		523124 DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11		SRC_HUMAN (6-130): 5.78e-19: 90.1: 21.26
+	Mm
		782845 DOK1_MOUSE (6-393): 3.94e-113: 341: 34.51		CSK_MOUSE (4-143): 8.51e-17: 83.3: 14.38
+	Mm
		956520 DOK1_MOUSE (6-393): 3.94e-113: 341: 34.51		GRB2_MOUSE (3-58): 7.7e-17: 80.6: 28.57
+	Mm
		623689 DOK1_MOUSE (6-393): 3.94e-113: 341: 34.51		TEC_MOUSE (6-108): 1.15e-14: 77.5: 22.12