Protein: PLRG1
Pleiotropic regulator 1

Gene: PLRG1
Organism: Homo sapiens
Interactions: 161
UniProt ID: O43660

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0001650 - fibrillar center
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

222529

DHX35
Probable ATP-dependent RNA helicase DHX35

2

20

High-throughput

0.811

High

222544

ISY1
Pre-mRNA-splicing factor ISY1 homolog

2

2

High-throughput

0.811

High

222478

SNW1
SNW domain-containing protein 1

2

5

High-throughput

0.789

High

222519

CDC5L
Cell division cycle 5-like protein

9

10

Small-scale

0.759

High

222547

PRP19
Pre-mRNA-processing factor 19

9

18

Small-scale

0.755

High

222464

H4
Histone H4

2

6

High-throughput

0.754

High

222500

PRP8
Pre-mRNA-processing-splicing factor 8

2

5

High-throughput

0.754

High

222406

SPF27
Pre-mRNA-splicing factor SPF27

6

5

Small-scale

0.740

High

222539

CWC15
Spliceosome-associated protein CWC15 homolog

2

1

Small-scale

0.737

High

222447

IF4A3
Eukaryotic initiation factor 4A-III

1

18

High-throughput

0.691

High

222530

UBP42
Ubiquitin carboxyl-terminal hydrolase 42

1

8

High-throughput

0.691

High

222534

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

14

High-throughput

0.691

High

222523

YJU2
Splicing factor YJU2

3

2

High-throughput

0.667

High

222521

USB1
U6 snRNA phosphodiesterase 1

4

0

Small-scale

0.664

High

222414

MYC
Myc proto-oncogene protein

3

20

High-throughput

0.640

High

222399

AQR
RNA helicase aquarius

2

9

High-throughput

0.628

High

222413

SYF2
Pre-mRNA-splicing factor SYF2

2

1

High-throughput

0.628

High

222479

CUL3
Cullin-3

2

20

High-throughput

0.628

High

222493

C19L2
CWF19-like protein 2

2

2

High-throughput

0.628

High

222522

GPTC1
G patch domain-containing protein 1

2

7

High-throughput

0.628

High

222525

CRNL1
Crooked neck-like protein 1

2

20

High-throughput

0.628

High

222535

SYF1
Pre-mRNA-splicing factor SYF1

2

20

High-throughput

0.628

High

222548

PPIE
Peptidyl-prolyl cis-trans isomerase E

2

3

High-throughput

0.628

High

222404

SF3B1
Splicing factor 3B subunit 1

2

9

High-throughput

0.625

High

222408

RECQ4
ATP-dependent DNA helicase Q4

1

20

High-throughput

0.618

High

222441

H2B1B
Histone H2B type 1-B

1

7

High-throughput

0.618

High

222462

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

9

High-throughput

0.618

High

222481

DHX8
ATP-dependent RNA helicase DHX8

1

19

High-throughput

0.618

High

222484

SUZ12
Polycomb protein SUZ12

1

3

High-throughput

0.618

High

222488

EZH2
Histone-lysine N-methyltransferase EZH2

1

17

High-throughput

0.618

High

222515

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

16

High-throughput

0.618

High

222526

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

3

High-throughput

0.618

High

222536

ANLN
Anillin

1

3

High-throughput

0.618

High

222551

TRRAP
Transformation/transcription domain-associated protein

1

7

High-throughput

0.618

High

222445

FUS
RNA-binding protein FUS

2

17

High-throughput

0.611

High

222480

RBM39
RNA-binding protein 39

2

15

High-throughput

0.611

High

222486

SF3A2
Splicing factor 3A subunit 2

2

7

High-throughput

0.611

High

222512

CTBL1
Beta-catenin-like protein 1

2

1

Small-scale

0.611

High

222454

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

8

High-throughput

0.592

High

222503

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.586

High

128641

MEN1
Menin

2

3

High-throughput

0.584

High

222398

PRKN
E3 ubiquitin-protein ligase parkin

2

12

High-throughput

0.584

High

222401

BRD4
Bromodomain-containing protein 4

2

18

High-throughput

0.584

High

222543

DDX41
Probable ATP-dependent RNA helicase DDX41

1

15

High-throughput

0.575

High

222420

JUN
Transcription factor Jun

2

13

High-throughput

0.571

High

156726

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.553

High

222502

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.553

High

222528

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.553

High

222533

RC3H2
Roquin-2

1

15

High-throughput

0.553

High

222541

DYH17
Dynein axonemal heavy chain 17

1

7

High-throughput

0.553

High

222419

A4
Amyloid-beta precursor protein

2

2

High-throughput

0.550

High

222507

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

2

High-throughput

0.541

High

166471

BACH1
Transcription regulator protein BACH1

1

13

High-throughput

0.536

High

222402

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

11

High-throughput

0.536

High

222423

RU2B
U2 small nuclear ribonucleoprotein B''

1

16

High-throughput

0.536

High

222426

SNRPA
U1 small nuclear ribonucleoprotein A

1

12

High-throughput

0.536

High

222427

RU1C
U1 small nuclear ribonucleoprotein C

1

2

High-throughput

0.536

High

222430

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.536

High

222431

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

4

High-throughput

0.536

High

222435

CSK22
Casein kinase II subunit alpha'

1

13

High-throughput

0.536

High

222446

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.536

High

222463

RUXF
Small nuclear ribonucleoprotein F

1

13

High-throughput

0.536

High

222467

RBM6
RNA-binding protein 6

1

17

High-throughput

0.536

High

222471

FMR1
Fragile X messenger ribonucleoprotein 1

1

11

High-throughput

0.536

High

222472

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.536

High

222476

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

18

High-throughput

0.536

High

222477

HDAC1
Histone deacetylase 1

1

18

High-throughput

0.536

High

222487

SF3A1
Splicing factor 3A subunit 1

1

9

High-throughput

0.536

High

222491

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

16

High-throughput

0.536

High

222501

RHG36
Rho GTPase-activating protein 36

2

6

High-throughput

0.521

High

222540

RHG23
Rho GTPase-activating protein 23

2

3

High-throughput

0.521

High

222457

ATX1
Ataxin-1

1

4

High-throughput

0.515

High

222422

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.513

High

222453

CNN1
Calponin-1

1

3

High-throughput

0.512

High

222434

EGLN
Endoglin

1

2

High-throughput

0.489

High

222436

MX1
Interferon-induced GTP-binding protein Mx1

1

3

Small-scale

0.481

High

131600

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

134486

SAP18
Histone deacetylase complex subunit SAP18

1

3

High-throughput

0.479

High

172295

XPO1
Exportin-1

1

11

High-throughput

0.479

High

222400

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

222403

TAD2A
Transcriptional adapter 2-alpha

1

20

High-throughput

0.479

High

222407

RNF8
E3 ubiquitin-protein ligase RNF8

1

9

Small-scale

0.479

High

222409

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

222411

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

2

High-throughput

0.479

High

222415

ESR1
Estrogen receptor

1

20

High-throughput

0.479

High

222416

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

High-throughput

0.479

High

222417

MYCN
N-myc proto-oncogene protein

1

20

High-throughput

0.479

High

222421

GLI1
Zinc finger protein GLI1

1

6

Small-scale

0.479

High

222424

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

8

High-throughput

0.479

High

222425

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

222428

ANDR
Androgen receptor

1

19

High-throughput

0.479

High

222429

HSP7C
Heat shock cognate 71 kDa protein

1

10

High-throughput

0.479

High

222432

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

222433

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

222438

U2AF2
Splicing factor U2AF 65 kDa subunit

1

18

Small-scale

0.479

High

222439

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

222440

STIP1
Stress-induced-phosphoprotein 1

1

10

High-throughput

0.479

High

222442

BMI1
Polycomb complex protein BMI-1

1

17

High-throughput

0.479

High

222443

PHB1
Prohibitin 1

1

5

High-throughput

0.479

High

222444

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

222448

CCNF
Cyclin-F

1

7

High-throughput

0.479

High

222449

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

9

High-throughput

0.479

High

222451

GSK3A
Glycogen synthase kinase-3 alpha

1

8

High-throughput

0.479

High

222452

MECP2
Methyl-CpG-binding protein 2

1

8

High-throughput

0.479

High

222455

IMA1
Importin subunit alpha-1

1

7

Small-scale

0.479

High

222456

IMA5
Importin subunit alpha-5

1

7

Small-scale

0.479

High

222458

TERA
Transitional endoplasmic reticulum ATPase

1

6

Small-scale

0.479

High

222460

MGN
Protein mago nashi homolog

1

1

High-throughput

0.479

High

222461

WDR5
WD repeat-containing protein 5

1

18

High-throughput

0.479

High

222465

YBOX1
Y-box-binding protein 1

1

6

Small-scale

0.479

High

222466

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

222469

VIGLN
Vigilin

1

17

High-throughput

0.479

High

222470

MECOM
Histone-lysine N-methyltransferase MECOM

1

3

High-throughput

0.479

High

222473

EP300
Histone acetyltransferase p300

1

12

High-throughput

0.479

High

222474

NFIA
Nuclear factor 1 A-type

1

18

High-throughput

0.479

High

222475

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

222482

MDC1
Mediator of DNA damage checkpoint protein 1

1

20

High-throughput

0.479

High

222483

NFIX
Nuclear factor 1 X-type

1

19

High-throughput

0.479

High

222485

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

222490

E2F4
Transcription factor E2F4

1

3

High-throughput

0.479

High

222492

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.479

High

222494

LARP7
La-related protein 7

1

19

High-throughput

0.479

High

222504

ZCH18
Zinc finger CCCH domain-containing protein 18

1

20

High-throughput

0.479

High

222506

SRRM1
Serine/arginine repetitive matrix protein 1

1

17

High-throughput

0.479

High

222510

SNIP1
Smad nuclear-interacting protein 1

1

4

High-throughput

0.479

High

222511

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

222513

ESR2
Estrogen receptor beta

1

19

High-throughput

0.479

High

222514

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

222517

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

222520

ANM1
Protein arginine N-methyltransferase 1

1

6

High-throughput

0.479

High

222524

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

222532

PRD16
Histone-lysine N-methyltransferase PRDM16

1

3

High-throughput

0.479

High

222538

DJC17
DnaJ homolog subfamily C member 17

1

15

High-throughput

0.479

High

222542

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

222546

FZR1
Fizzy-related protein homolog

1

19

High-throughput

0.479

High

222549

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.479

High

222550

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

15

High-throughput

0.479

High

222552

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

1

1

High-throughput

0.479

High

222495

EAPP
E2F-associated phosphoprotein

1

0

High-throughput

0.458

High

222505

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

222508

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

222496

ODFP2
Outer dense fiber protein 2

1

13

High-throughput

0.445

High

222531

LN28A
Protein lin-28 homolog A

1

8

High-throughput

0.445

High

222405

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

222412

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

16

High-throughput

0.437

High

222418

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.437

High

222489

CCDC6
Coiled-coil domain-containing protein 6

1

15

High-throughput

0.437

High

222498

RC3H1
Roquin-1

1

3

High-throughput

0.437

High

222516

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

222527

CPVL
Probable serine carboxypeptidase CPVL

1

1

High-throughput

0.437

High

222545

HECD1
E3 ubiquitin-protein ligase HECTD1

1

12

High-throughput

0.437

High

222450

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.408

High

222410

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

3

High-throughput

0.407

High

222459

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

High-throughput

0.407

High

222509

LINES
Protein Lines homolog 1

2

0

High-throughput

0.328

High

222468

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

222437

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.249

Low

222499

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

222518

RN157
E3 ubiquitin ligase RNF157

1

0

Small-scale

0.249

Low

222537

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.249

Low

222497

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025