HitPredict

Interactor 1: IGSF3 (O75054)
Immunoglobulin superfamily member 3 (IgSF3) (Glu-Trp-Ile EWI motif-containing protein 3) (EWI-3)
Gene: IGSF3

Interactor 2: RHOH (Q15669)
Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein)
Gene: RHOH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~V-set
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1194 Hs			1 191
+	Hs
		253642 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		253645 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		253624 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RHOQ_HUMAN (5-190): 8.15e-74: 222: 39.49
+	Hs
		253636 IGSF3_HUMAN (1-1194): 0: 758: 100.00		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		253622 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07
+	Hs
		253635 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RAC3_HUMAN (2-171): 3.86e-72: 218: 41.81
+	Hs
		253648 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RHOG_HUMAN (2-191): 2.32e-71: 216: 37.56
+	Hs
		253638 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Hs
		1076841 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RHOH_HUMAN (1-191): 2.74e-95: 276: 100.00
+	Hs
		915725 SDK2_HUMAN (583-1172): 1.81e-22: 107: 12.14		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		436602 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RHOC_HUMAN (6-185): 6.48e-85: 250: 42.25
+	Hs
		916112 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		530163 NCAM1_HUMAN (33-559): 4.87e-18: 92.2: 13.96		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		894044 MYLK_HUMAN (668-1141): 7.03e-22: 105: 12.15		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		925776 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		564764 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RHOQ_HUMAN (5-190): 8.15e-74: 222: 39.49
+	Hs
		894644 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		901110 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Ce
		136793 UNC89_CAEEL (571-775): 1.82e-09: 64.6: 11.01		RAC1_CAEEL (2-191): 1.19e-74: 224: 40.10
+	Ce
		104464 UNC89_CAEEL (571-775): 1.82e-09: 64.6: 11.01		G5EBV3_CAEEL (3-191): 1.16e-71: 216: 40.82