Protein: IMA3
Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4)

Gene: IMA3, KPNA4
Organism: Homo sapiens
Interactions: 201
UniProt ID: O00629

Gene Ontology (top 5):
GO:0001673 - male germ cell nucleus
GO:0005634 - nucleus
GO:0005643 - nuclear pore
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

142633

NUP50
Nuclear pore complex protein Nup50

7

20

High-throughput

0.971

High

142553

IMB1
Importin subunit beta-1

6

20

Small-scale

0.950

High

142520

RAN
GTP-binding nuclear protein Ran

3

6

High-throughput

0.871

High

138588

IMA4
Importin subunit alpha-4

2

8

High-throughput

0.789

High

142572

BCOR
BCL-6 corepressor

2

9

Small-scale

0.789

High

142472

ESR1
Estrogen receptor

2

9

High-throughput

0.737

High

142479

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

5

6

High-throughput

0.721

High

142484

RCC1
Regulator of chromosome condensation

5

2

Small-scale

0.720

High

142507

MECP2
Methyl-CpG-binding protein 2

4

9

High-throughput

0.704

High

142551

KIF22
Kinesin-like protein KIF22

4

3

High-throughput

0.704

High

142521

RAC1
Ras-related C3 botulinum toxin substrate 1

1

8

High-throughput

0.698

High

142543

MTA1
Metastasis-associated protein MTA1

4

12

High-throughput

0.692

High

142502

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.691

High

142598

TNPO1
Transportin-1

1

20

High-throughput

0.691

High

142600

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

5

High-throughput

0.691

High

142564

NCBP3
Nuclear cap-binding protein subunit 3

4

2

High-throughput

0.676

High

142545

HDAC1
Histone deacetylase 1

3

13

High-throughput

0.675

High

142613

IER2
Immediate early response gene 2 protein

3

1

High-throughput

0.667

High

142533

TF65
Transcription factor p65

4

9

Small-scale

0.666

High

142470

MYC
Myc proto-oncogene protein

3

7

Small-scale

0.664

High

142537

NCBP1
Nuclear cap-binding protein subunit 1

3

5

High-throughput

0.662

High

142534

CTSL2
CTD small phosphatase-like protein 2

3

4

Small-scale

0.651

High

142514

XPO2
Exportin-2

1

20

Small-scale

0.647

High

142505

NU153
Nuclear pore complex protein Nup153

2

20

High-throughput

0.628

High

142510

NCBP2
Nuclear cap-binding protein subunit 2

2

5

High-throughput

0.628

High

142519

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

2

4

High-throughput

0.628

High

142531

HSF1
Heat shock factor protein 1

2

4

High-throughput

0.628

High

142603

P121A
Nuclear envelope pore membrane protein POM 121

2

15

High-throughput

0.628

High

142625

DDX21
Nucleolar RNA helicase 2

2

4

High-throughput

0.628

High

142626

MRGBP
MRG/MORF4L-binding protein

2

2

High-throughput

0.628

High

142474

P53
Cellular tumor antigen p53

2

1

Small-scale

0.624

High

142643

NCOR2
Nuclear receptor corepressor 2

2

3

Small-scale

0.619

High

142578

ARMC8
Armadillo repeat-containing protein 8

1

10

High-throughput

0.618

High

142611

CIC
Protein capicua homolog

1

7

High-throughput

0.618

High

142546

CUL3
Cullin-3

2

13

High-throughput

0.611

High

142599

KAT5
Histone acetyltransferase KAT5

2

7

High-throughput

0.606

High

142640

FA50B
Protein FAM50B

2

1

High-throughput

0.606

High

142497

CBX5
Chromobox protein homolog 5

2

16

Small-scale

0.601

High

142560

NF2L2
Nuclear factor erythroid 2-related factor 2

1

8

Small-scale

0.598

High

142471

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

12

High-throughput

0.586

High

142457

PRKN
E3 ubiquitin-protein ligase parkin

2

11

High-throughput

0.584

High

142463

TRIM3
Tripartite motif-containing protein 3

2

8

Small-scale

0.584

High

142563

LARP7
La-related protein 7

2

7

High-throughput

0.584

High

142468

MED26
Mediator of RNA polymerase II transcription subunit 26

2

0

High-throughput

0.576

High

142628

MAT2B
Methionine adenosyltransferase 2 subunit beta

1

2

High-throughput

0.573

High

142641

PLAP
Phospholipase A-2-activating protein

1

7

High-throughput

0.573

High

142544

SQSTM
Sequestosome-1

2

3

High-throughput

0.563

High

142458

NUPR1
Nuclear protein 1

1

4

High-throughput

0.561

High

142617

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

2

1

High-throughput

0.553

High

142500

RECQ1
ATP-dependent DNA helicase Q1

1

6

Small-scale

0.552

High

142526

CSK21
Casein kinase II subunit alpha

1

5

High-throughput

0.550

High

142485

WT1
Wilms tumor protein

1

8

High-throughput

0.541

High

142503

NRIP1
Nuclear receptor-interacting protein 1

1

1

High-throughput

0.541

High

142549

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.541

High

142550

MORC3
MORC family CW-type zinc finger protein 3

1

1

High-throughput

0.541

High

140658

NOP56
Nucleolar protein 56

1

14

High-throughput

0.536

High

142451

CUX2
Homeobox protein cut-like 2

1

2

High-throughput

0.536

High

142454

MCES
mRNA cap guanine-N(7) methyltransferase

1

5

High-throughput

0.536

High

142460

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

6

High-throughput

0.536

High

142461

MCE1
mRNA-capping enzyme

1

4

High-throughput

0.536

High

142467

MTA2
Metastasis-associated protein MTA2

1

12

High-throughput

0.536

High

142469

MBD3
Methyl-CpG-binding domain protein 3

1

4

High-throughput

0.536

High

142477

RB
Retinoblastoma-associated protein

1

1

High-throughput

0.536

High

142488

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

5

High-throughput

0.536

High

142495

RANG
Ran-specific GTPase-activating protein

1

20

High-throughput

0.536

High

142498

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.536

High

142499

RAGP1
Ran GTPase-activating protein 1

1

3

High-throughput

0.536

High

142506

RBP2
E3 SUMO-protein ligase RanBP2

1

10

High-throughput

0.536

High

142511

HMGA2
High mobility group protein HMGI-C

1

1

High-throughput

0.536

High

142517

NU107
Nuclear pore complex protein Nup107

1

1

High-throughput

0.536

High

142518

PSME3
Proteasome activator complex subunit 3

1

1

High-throughput

0.536

High

142523

SUMO1
Small ubiquitin-related modifier 1

1

2

High-throughput

0.536

High

142524

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.536

High

142527

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.536

High

142528

GTF2I
General transcription factor II-I

1

4

High-throughput

0.536

High

142532

SET
Protein SET

1

1

High-throughput

0.536

High

142536

RBBP4
Histone-binding protein RBBP4

1

12

High-throughput

0.536

High

142538

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

2

High-throughput

0.536

High

142552

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.536

High

142554

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

4

High-throughput

0.536

High

142558

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.536

High

142565

AKIR2
Akirin-2

1

3

High-throughput

0.536

High

142568

RIF1
Telomere-associated protein RIF1

1

3

High-throughput

0.536

High

142576

RAI1
Retinoic acid-induced protein 1

1

4

High-throughput

0.536

High

142579

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

2

High-throughput

0.536

High

142593

P66B
Transcriptional repressor p66-beta

1

5

High-throughput

0.536

High

142595

HDAC2
Histone deacetylase 2

1

13

High-throughput

0.536

High

142597

SMRC1
SWI/SNF complex subunit SMARCC1

1

4

High-throughput

0.536

High

142605

Z512B
Zinc finger protein 512B

1

8

High-throughput

0.536

High

142608

KI20B
Kinesin-like protein KIF20B

1

7

High-throughput

0.536

High

142620

PHAX
Phosphorylated adapter RNA export protein

1

3

High-throughput

0.536

High

142624

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

20

High-throughput

0.536

High

142516

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.518

High

142482

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.515

High

142489

ARRB2
Beta-arrestin-2

1

2

High-throughput

0.515

High

67519

MYH7B
Myosin-7B

1

0

High-throughput

0.513

High

142462

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.513

High

142509

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.513

High

142522

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

High-throughput

0.513

High

142644

CFA20
Cilia- and flagella-associated protein 20

1

0

High-throughput

0.513

High

142452

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

7

High-throughput

0.501

High

142464

CDC45
Cell division control protein 45 homolog

1

2

High-throughput

0.501

High

142475

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

142478

NPM
Nucleophosmin

1

4

Small-scale

0.501

High

142501

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

8

Small-scale

0.501

High

142535

MEF2C
Myocyte-specific enhancer factor 2C

1

1

High-throughput

0.501

High

142548

CUL4B
Cullin-4B

1

13

Small-scale

0.501

High

142562

HIF1A
Hypoxia-inducible factor 1-alpha

1

13

Small-scale

0.501

High

142592

ZN526
Zinc finger protein 526

1

4

High-throughput

0.501

High

142596

CBP
CREB-binding protein

1

13

High-throughput

0.501

High

142616

RNF38
E3 ubiquitin-protein ligase RNF38

1

1

High-throughput

0.501

High

142619

RANB3
Ran-binding protein 3

1

20

High-throughput

0.501

High

142540

TADBP
TAR DNA-binding protein 43

1

3

Small-scale

0.500

High

142577

F90A1
Protein FAM90A1

1

2

High-throughput

0.489

High

142561

NTRK3
NT-3 growth factor receptor

1

4

Small-scale

0.481

High

142632

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

4

Small-scale

0.481

High

142571

ABRX1
BRCA1-A complex subunit Abraxas 1

1

0

High-throughput

0.480

High

142638

EXO1
Exonuclease 1

1

0

Small-scale

0.480

High

66722

RGPD3
RanBP2-like and GRIP domain-containing protein 3

1

20

High-throughput

0.479

High

71415

P20L1
PHD finger protein 20-like protein 1

1

2

High-throughput

0.479

High

142453

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

5

High-throughput

0.479

High

142456

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

142459

CCNT1
Cyclin-T1

1

3

High-throughput

0.479

High

142465

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

142466

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.479

High

142481

TAU
Microtubule-associated protein tau

1

9

High-throughput

0.479

High

142483

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

142487

PML
Protein PML

1

8

Small-scale

0.479

High

142491

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

142493

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

4

High-throughput

0.479

High

142494

WASP
Actin nucleation-promoting factor WAS

1

5

Small-scale

0.479

High

142496

NKX21
Homeobox protein Nkx-2.1

1

3

High-throughput

0.479

High

142504

CTCF
Transcriptional repressor CTCF

1

7

Small-scale

0.479

High

142515

FOXA1
Hepatocyte nuclear factor 3-alpha

1

3

High-throughput

0.479

High

142525

ACTC
Actin, alpha cardiac muscle 1

1

4

High-throughput

0.479

High

142530

H33
Histone H3.3

1

7

Small-scale

0.479

High

142539

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

2

High-throughput

0.479

High

142542

TIF1B
Transcription intermediary factor 1-beta

1

7

High-throughput

0.479

High

142547

CUL4A
Cullin-4A

1

13

High-throughput

0.479

High

142555

HAPR1
HUWE1-associated protein modifying stress responses 1

1

4

High-throughput

0.479

High

142556

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

142559

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

High-throughput

0.479

High

142569

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.479

High

142573

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.479

High

142574

MEPCE
7SK snRNA methylphosphate capping enzyme

1

6

High-throughput

0.479

High

142587

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

142589

COP1
E3 ubiquitin-protein ligase COP1

1

18

High-throughput

0.479

High

142591

PARD3
Partitioning defective 3 homolog

1

1

Small-scale

0.479

High

142594

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

142601

OPTN
Optineurin

1

6

High-throughput

0.479

High

142602

TRI11
E3 ubiquitin-protein ligase TRIM11

1

2

Small-scale

0.479

High

142606

SNX27
Sorting nexin-27

1

1

High-throughput

0.479

High

142610

NACC1
Nucleus accumbens-associated protein 1

1

16

Small-scale

0.479

High

142614

AICDA
Single-stranded DNA cytosine deaminase

1

5

Small-scale

0.479

High

142621

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.479

High

142622

SENP2
Sentrin-specific protease 2

1

4

Small-scale

0.479

High

142629

NXF1
Nuclear RNA export factor 1

1

4

High-throughput

0.479

High

142631

ZRAN1
Ubiquitin thioesterase ZRANB1

1

15

High-throughput

0.479

High

142637

PRP19
Pre-mRNA-processing factor 19

1

8

High-throughput

0.479

High

142642

TRRAP
Transformation/transcription domain-associated protein

1

6

High-throughput

0.479

High

142480

PKHD1
Fibrocystin

1

0

High-throughput

0.458

High

142486

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

Small-scale

0.458

High

142513

COPA
Coatomer subunit alpha

1

0

High-throughput

0.458

High

142627

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

142630

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.458

High

142557

SF01
Splicing factor 1

1

7

High-throughput

0.457

High

68006

P121C
Nuclear envelope pore membrane protein POM 121C

1

18

High-throughput

0.445

High

142473

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.445

High

142476

JUN
Transcription factor Jun

1

7

High-throughput

0.445

High

142490

MERL
Merlin

1

2

High-throughput

0.445

High

142529

CBX1
Chromobox protein homolog 1

1

16

Small-scale

0.445

High

142541

CBX3
Chromobox protein homolog 3

1

16

Small-scale

0.445

High

142567

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

142575

RGPD4
RanBP2-like and GRIP domain-containing protein 4

1

20

High-throughput

0.445

High

142581

SLX4
Structure-specific endonuclease subunit SLX4

1

7

High-throughput

0.445

High

142586

ZBT34
Zinc finger and BTB domain-containing protein 34

1

17

Small-scale

0.445

High

142604

LCOR
Ligand-dependent corepressor

1

1

High-throughput

0.445

High

142636

AKP8L
A-kinase anchor protein 8-like

1

3

High-throughput

0.445

High

76076

B4DET5
cDNA FLJ59484, highly similar to Nuclear envelope pore membrane protein POM 121

1

17

High-throughput

0.437

High

142584

S4A11
Solute carrier family 4 member 11

1

1

High-throughput

0.437

High

142455

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.426

High

142590

CE192
Centrosomal protein of 192 kDa

1

0

High-throughput

0.426

High

142512

NKX25
Homeobox protein Nkx-2.5

1

3

High-throughput

0.408

High

142566

ZRAB3
DNA annealing helicase and endonuclease ZRANB3

1

20

High-throughput

0.408

High

142570

SCND3
SCAN domain-containing protein 3

1

1

High-throughput

0.408

High

142583

RYBP
RING1 and YY1-binding protein

1

1

Small-scale

0.408

High

142588

ZMIZ2
Zinc finger MIZ domain-containing protein 2

1

2

High-throughput

0.408

High

142607

PKH4B
Pleckstrin homology domain-containing family G member 4B

1

1

High-throughput

0.408

High

142615

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.408

High

142618

ADNP
Activity-dependent neuroprotector homeobox protein

1

4

High-throughput

0.408

High

142623

ZN532
Zinc finger protein 532

1

3

High-throughput

0.408

High

142634

MRTFB
Myocardin-related transcription factor B

1

1

High-throughput

0.408

High

142635

TPX2
Targeting protein for Xklp2

1

3

High-throughput

0.408

High

142639

DMTF1
Cyclin-D-binding Myb-like transcription factor 1

1

2

High-throughput

0.408

High

142492

VGFR2
Vascular endothelial growth factor receptor 2

1

0

High-throughput

0.391

High

142585

HJURP
Holliday junction recognition protein

1

0

High-throughput

0.391

High

142508

AFF2
AF4/FMR2 family member 2

1

6

High-throughput

0.373

High

142612

SOST
Sclerostin

2

0

High-throughput

0.328

High

142580

CI040
Uncharacterized protein C9orf40

1

0

High-throughput

0.279

Low

142582

SELH
Selenoprotein H

1

0

High-throughput

0.279

Low

142609

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025