Interactor 1: LRP4 (O75096)
Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7)
Gene: LRP4
Interactor 2: SOST (Q9BQB4)
Sclerostin
Gene: SOST
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.78 | 1.00 | 0.886 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 28514442, 33961781, 21471202 |
| Identification Methods | affinity chromatography technology, surface plasmon resonance, tandem affinity purification, enzyme linked immunosorbent assay, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Ldl_recept_b~Sclerostin |
| Common GO terms | GO:0030279 - negative regulation of ossification GO:0090090 - negative regulation of canonical Wnt signaling pathway |
| Homologous interactions | 6 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
