Protein: ICMT
Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) (Isoprenylcysteine carboxylmethyltransferase) (Prenylated protein carboxyl methyltransferase) (PPMT) (Prenylcysteine carboxyl methyltransferase) (pcCMT)

Gene: ICMT
Organism: Homo sapiens
Interactions: 60
UniProt ID: O60725

Gene Ontology (top 5):
GO:0003880 - protein C-terminal carboxyl O-methyltransferase activity
GO:0004671 - protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006481 - C-terminal protein methylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

254284

TRI32
E3 ubiquitin-protein ligase TRIM32

2

0

High-throughput

0.580

High

254292

RN19B
E3 ubiquitin-protein ligase RNF19B

2

0

High-throughput

0.580

High

254298

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.580

High

254286

AQP6
Aquaporin-6

2

1

High-throughput

0.553

High

254271

CALX
Calnexin

2

0

High-throughput

0.547

High

254301

AQP3
Aquaporin-3

1

1

High-throughput

0.536

High

182430

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.513

High

254265

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

0

High-throughput

0.513

High

254283

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

254296

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

254297

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

254302

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

254266

RAC2
Ras-related C3 botulinum toxin substrate 2

1

1

Small-scale

0.501

High

254280

RHOA
Transforming protein RhoA

1

1

Small-scale

0.501

High

254274

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

1

High-throughput

0.489

High

254277

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

1

High-throughput

0.489

High

48454

ESYT2
Extended synaptotagmin-2

1

0

High-throughput

0.458

High

254262

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

254279

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

254287

CUL3
Cullin-3

1

0

High-throughput

0.458

High

254291

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.458

High

254306

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

254290

DUS28
Dual specificity phosphatase 28

1

1

High-throughput

0.437

High

254293

UN93A
Protein unc-93 homolog A

1

0

High-throughput

0.426

High

254308

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

Small-scale

0.426

High

125692

STXB3
Syntaxin-binding protein 3

2

0

High-throughput

0.328

High

254258

RA51D
DNA repair protein RAD51 homolog 4

2

0

High-throughput

0.328

High

254260

OXSR1
Serine/threonine-protein kinase OSR1

2

0

High-throughput

0.328

High

254263

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

2

0

High-throughput

0.328

High

254273

GRAN
Grancalcin

2

0

High-throughput

0.328

High

254268

MUC1
Mucin-1

2

0

High-throughput

0.316

High

254278

KCNJ6
G protein-activated inward rectifier potassium channel 2

2

0

High-throughput

0.316

High

254285

PDZ1I
PDZK1-interacting protein 1

2

0

High-throughput

0.316

High

254289

AR13B
ADP-ribosylation factor-like protein 13B

2

0

High-throughput

0.316

High

254264

KPCB
Protein kinase C beta type

2

0

High-throughput

0.298

High

254269

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.298

High

165869

FFAR1
Free fatty acid receptor 1

1

0

High-throughput

0.279

Low

254295

RELL1
RELT-like protein 1

1

0

High-throughput

0.279

Low

254300

PPM1E
Protein phosphatase 1E

1

0

High-throughput

0.279

Low

254313

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

254259

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

254261

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

254267

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

254270

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

254272

DUS1
Dual specificity protein phosphatase 1

1

0

High-throughput

0.249

Low

254275

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

254276

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

254281

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

254282

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

254288

KS6A1
Ribosomal protein S6 kinase alpha-1

1

0

High-throughput

0.249

Low

254294

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.249

Low

254303

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

254304

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

254305

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

254307

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

254309

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

0

High-throughput

0.249

Low

254310

UBQL2
Ubiquilin-2

1

0

High-throughput

0.249

Low

254312

ALK
ALK tyrosine kinase receptor

1

0

Small-scale

0.249

Low

254299

CTR3
Cationic amino acid transporter 3

1

0

High-throughput

0.232

Low

254311

S23A1
Solute carrier family 23 member 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025