Protein: SENP2
Sentrin-specific protease 2 (EC 3.4.22.-) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2)

Gene: SENP2
Organism: Homo sapiens
Interactions: 163
UniProt ID: Q9HC62

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005643 - nuclear pore
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

879156

SUMO3
Small ubiquitin-related modifier 3

5

20

Small-scale

0.938

High

928203

SUMO1
Small ubiquitin-related modifier 1

4

20

Small-scale

0.888

High

902760

SUMO2
Small ubiquitin-related modifier 2

3

20

Small-scale

0.877

High

801780

RAGP1
Ran GTPase-activating protein 1

2

3

Small-scale

0.778

High

834672

NU153
Nuclear pore complex protein Nup153

3

8

Small-scale

0.664

High

1335832

NEMO
NF-kappa-B essential modulator

2

1

Small-scale

0.660

High

1244506

NUP43
Nucleoporin Nup43

3

10

High-throughput

0.640

High

422703

PGK2
Phosphoglycerate kinase 2

2

1

High-throughput

0.628

High

1301520

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

2

5

High-throughput

0.628

High

904146

HNRPK
Heterogeneous nuclear ribonucleoprotein K

3

0

Small-scale

0.622

High

884795

NU107
Nuclear pore complex protein Nup107

2

1

High-throughput

0.611

High

1232735

RDHE2
Epidermal retinol dehydrogenase 2

2

1

High-throughput

0.606

High

395814

A4
Amyloid-beta precursor protein

2

1

High-throughput

0.602

High

924415

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

Small-scale

0.586

High

595424

LMNB1
Lamin-B1

2

8

Small-scale

0.584

High

890436

SC61B
Protein transport protein Sec61 subunit beta

2

1

High-throughput

0.584

High

864268

CCHL
Holocytochrome c-type synthase

2

0

High-throughput

0.580

High

1135395

ARM12
Armadillo repeat-containing protein 12

2

0

High-throughput

0.580

High

771054

TCPZ
T-complex protein 1 subunit zeta

2

0

Small-scale

0.576

High

1069655

STK38
Serine/threonine-protein kinase 38

1

1

Small-scale

0.561

High

1335827

FZR1
Fizzy-related protein homolog

1

7

Small-scale

0.561

High

390544

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

0

Small-scale

0.559

High

1286918

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

2

1

High-throughput

0.553

High

1065326

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.549

High

380866

S100B
Protein S100-B

1

4

High-throughput

0.536

High

1291120

CDCA5
Sororin

1

0

High-throughput

0.518

High

1302333

CK5P2
CDK5 regulatory subunit-associated protein 2

1

0

High-throughput

0.518

High

175220

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

347943

MYC
Myc proto-oncogene protein

1

2

Small-scale

0.501

High

487774

ANDR
Androgen receptor

1

5

Small-scale

0.501

High

853719

IMA5
Importin subunit alpha-5

1

4

Small-scale

0.501

High

976515

ERCC6
DNA excision repair protein ERCC-6

1

4

High-throughput

0.501

High

1060931

IMB1
Importin subunit beta-1

1

5

Small-scale

0.501

High

1282046

TRI63
E3 ubiquitin-protein ligase TRIM63

1

3

High-throughput

0.501

High

1299639

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

3

High-throughput

0.501

High

1300837

NACC1
Nucleus accumbens-associated protein 1

1

6

Small-scale

0.501

High

1335822

DAXX
Death domain-associated protein 6

1

2

Small-scale

0.501

High

283036

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

7

High-throughput

0.489

High

360436

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

8

High-throughput

0.481

High

48518

ESYT2
Extended synaptotagmin-2

1

3

High-throughput

0.479

High

59925

SH321
SH3 domain-containing protein 21

1

2

Small-scale

0.479

High

120652

RHOD
Rho-related GTP-binding protein RhoD

1

15

High-throughput

0.479

High

131516

IMA4
Importin subunit alpha-4

1

4

Small-scale

0.479

High

134967

IMA3
Importin subunit alpha-3

1

4

Small-scale

0.479

High

151204

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

1

High-throughput

0.479

High

207696

SYT7
Synaptotagmin-7

1

1

Small-scale

0.479

High

208793

SNAI2
Zinc finger protein SNAI2

1

3

Small-scale

0.479

High

273996

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.479

High

318729

EYA4
Eyes absent homolog 4

1

1

High-throughput

0.479

High

417424

ENOA
Alpha-enolase

1

4

Small-scale

0.479

High

428449

TBB5
Tubulin beta chain

1

2

Small-scale

0.479

High

436518

RHOC
Rho-related GTP-binding protein RhoC

1

11

High-throughput

0.479

High

483451

RBY1A
RNA-binding motif protein, Y chromosome, family 1 member A1

1

1

Small-scale

0.479

High

504788

HSP7C
Heat shock cognate 71 kDa protein

1

1

Small-scale

0.479

High

545629

RAC2
Ras-related C3 botulinum toxin substrate 2

1

10

High-throughput

0.479

High

567282

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

573922

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

580694

ML12A
Myosin regulatory light chain 12A

1

1

Small-scale

0.479

High

592022

RAB4A
Ras-related protein Rab-4A

1

1

High-throughput

0.479

High

668992

PML
Protein PML

1

7

High-throughput

0.479

High

707754

H2B1B
Histone H2B type 1-B

1

5

Small-scale

0.479

High

807239

RS5
Small ribosomal subunit protein uS7

1

1

Small-scale

0.479

High

839147

EMD
Emerin

1

1

High-throughput

0.479

High

843059

TCPQ
T-complex protein 1 subunit theta

1

1

Small-scale

0.479

High

843395

TCPD
T-complex protein 1 subunit delta

1

1

Small-scale

0.479

High

845749

RAB9A
Ras-related protein Rab-9A

1

3

High-throughput

0.479

High

853478

IMA1
Importin subunit alpha-1

1

4

Small-scale

0.479

High

894455

CDC42
Cell division control protein 42 homolog

1

11

High-throughput

0.479

High

900928

RHOA
Transforming protein RhoA

1

13

High-throughput

0.479

High

903533

WDR5
WD repeat-containing protein 5

1

6

High-throughput

0.479

High

917959

H4
Histone H4

1

2

Small-scale

0.479

High

920559

RS25
Small ribosomal subunit protein eS25

1

1

Small-scale

0.479

High

932876

EF1A1
Elongation factor 1-alpha 1

1

2

Small-scale

0.479

High

951357

RHOG
Rho-related GTP-binding protein RhoG

1

11

High-throughput

0.479

High

1017806

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

1056994

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

Small-scale

0.479

High

1070405

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.479

High

1080365

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

1167317

BCOR
BCL-6 corepressor

1

3

High-throughput

0.479

High

1167899

DJC14
DnaJ homolog subfamily C member 14

1

1

High-throughput

0.479

High

1168690

SYNE3
Nesprin-3

1

1

High-throughput

0.479

High

1201321

MORC1
MORC family CW-type zinc finger protein 1

1

1

Small-scale

0.479

High

1206198

HORN
Hornerin

1

4

Small-scale

0.479

High

1240307

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.479

High

1242574

RB15B
Putative RNA-binding protein 15B

1

3

High-throughput

0.479

High

1260350

NU133
Nuclear pore complex protein Nup133

1

1

High-throughput

0.479

High

1296079

DNJC1
DnaJ homolog subfamily C member 1

1

3

High-throughput

0.479

High

1300651

H2A1A
Histone H2A type 1-A

1

3

Small-scale

0.479

High

1313060

DERL1
Derlin-1

1

1

High-throughput

0.479

High

1329774

HIPK2
Homeodomain-interacting protein kinase 2

1

2

Small-scale

0.479

High

1333574

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.479

High

1335816

RN146
E3 ubiquitin-protein ligase RNF146

1

2

Small-scale

0.479

High

1335823

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1335824

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

5

Small-scale

0.479

High

1335829

RUVB2
RuvB-like 2

1

2

Small-scale

0.479

High

1335830

ST38L
Serine/threonine-protein kinase 38-like

1

1

Small-scale

0.479

High

315217

CNEP1
CTD nuclear envelope phosphatase 1

1

0

High-throughput

0.458

High

344338

AACT
Alpha-1-antichymotrypsin

1

0

Small-scale

0.458

High

361527

APOE
Apolipoprotein E

1

0

Small-scale

0.458

High

654799

CALX
Calnexin

1

0

High-throughput

0.458

High

786139

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

825560

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

847664

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

887501

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

Small-scale

0.458

High

891606

MYL6
Myosin light polypeptide 6

1

0

Small-scale

0.458

High

892045

ACTB
Actin, cytoplasmic 1

1

0

Small-scale

0.458

High

914372

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

935828

HBB
Hemoglobin subunit beta

1

0

Small-scale

0.458

High

940571

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.458

High

943494

TCPB
T-complex protein 1 subunit beta

1

0

Small-scale

0.458

High

946613

DCD
Dermcidin

1

0

Small-scale

0.458

High

1078669

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.458

High

1084907

SMN
Survival motor neuron protein

1

0

Small-scale

0.458

High

1148226

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.458

High

1244706

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1301229

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

0

High-throughput

0.458

High

1308825

SOSB1
SOSS complex subunit B1

1

0

Small-scale

0.458

High

1319255

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1335813

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1335819

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

1335825

ADA28
Disintegrin and metalloproteinase domain-containing protein 28

1

0

Small-scale

0.458

High

1335831

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

178795

STX7
Syntaxin-7

1

1

High-throughput

0.437

High

795290

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.437

High

933362

TBA1B
Tubulin alpha-1B chain

1

3

Small-scale

0.437

High

990690

CKAP4
Cytoskeleton-associated protein 4

1

2

High-throughput

0.437

High

1076769

RHOH
Rho-related GTP-binding protein RhoH

1

11

High-throughput

0.437

High

1159574

TTC27
Tetratricopeptide repeat protein 27

1

1

Small-scale

0.437

High

1230382

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

1283946

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.437

High

1284087

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.437

High

1303578

SEC62
Translocation protein SEC62

1

1

High-throughput

0.437

High

1309809

SYT15
Synaptotagmin-15

1

1

Small-scale

0.437

High

1311405

ESYT1
Extended synaptotagmin-1

1

3

High-throughput

0.437

High

1328860

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.437

High

1335814

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.437

High

1335817

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

1335818

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.437

High

236834

CCNT1
Cyclin-T1

1

0

High-throughput

0.426

High

1164270

ATRAP
Type-1 angiotensin II receptor-associated protein

3

0

High-throughput

0.352

High

1236089

KASH5
Protein KASH5

3

0

High-throughput

0.352

High

1262242

TM239
Transmembrane protein 239

3

0

High-throughput

0.352

High

874425

APOC4
Apolipoprotein C-IV

2

0

High-throughput

0.316

High

1202388

RETR3
Reticulophagy regulator 3

2

0

High-throughput

0.316

High

1335815

RPRM
Protein reprimo

2

0

High-throughput

0.316

High

1335821

TR10D
Tumor necrosis factor receptor superfamily member 10D

2

0

High-throughput

0.316

High

1217777

FUND1
FUN14 domain-containing protein 1

1

0

High-throughput

0.299

High

1231161

SYNE4
Nesprin-4

1

0

High-throughput

0.299

High

1335826

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.279

Low

361677

APOC2
Apolipoprotein C-II

1

0

High-throughput

0.251

Low

878053

TPD52
Tumor protein D52

1

0

High-throughput

0.251

Low

101192

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

163988

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.249

Low

391185

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

587405

ITIH1
Inter-alpha-trypsin inhibitor heavy chain H1

1

0

Small-scale

0.249

Low

961831

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.249

Low

1040266

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.249

Low

1203859

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1300785

PANX1
Pannexin-1

1

0

High-throughput

0.249

Low

1329286

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

1333984

GHC1
Mitochondrial glutamate carrier 1

1

0

Small-scale

0.249

Low

1335820

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.249

Low

1335828

MARE3
Microtubule-associated protein RP/EB family member 3

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024