Protein: DUS1
Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100)

Gene: DUS1, DUSP1
Organism: Homo sapiens
Interactions: 106
UniProt ID: P28562

Gene Ontology (top 5):
GO:0001706 - endoderm formation
GO:0004721 - phosphoprotein phosphatase activity
GO:0004722 - protein serine/threonine phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

703946

MK14
Mitogen-activated protein kinase 14

7

20

Small-scale

0.965

High

703444

MK01
Mitogen-activated protein kinase 1

6

20

Small-scale

0.946

High

691637

MK03
Mitogen-activated protein kinase 3

4

20

Small-scale

0.894

High

703915

MK08
Mitogen-activated protein kinase 8

2

20

Small-scale

0.800

High

703916

MK09
Mitogen-activated protein kinase 9

2

20

Small-scale

0.776

High

703909

DUS1
Dual specificity protein phosphatase 1

2

14

High-throughput

0.754

High

703921

MK10
Mitogen-activated protein kinase 10

1

20

Small-scale

0.665

High

703935

SKP2
S-phase kinase-associated protein 2

3

4

Small-scale

0.646

High

703934

ILF3
Interleukin enhancer-binding factor 3

3

2

Small-scale

0.643

High

703942

ELAV1
ELAV-like protein 1

3

3

Small-scale

0.643

High

167827

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

4

Small-scale

0.618

High

177801

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

5

Small-scale

0.618

High

703913

KPCI
Protein kinase C iota type

1

1

Small-scale

0.618

High

703918

DUS3
Dual specificity protein phosphatase 3

1

15

High-throughput

0.618

High

703943

MK11
Mitogen-activated protein kinase 11

1

20

Small-scale

0.618

High

135067

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

2

11

High-throughput

0.571

High

250470

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

2

4

High-throughput

0.571

High

345407

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

1

High-throughput

0.571

High

415369

HSPB1
Heat shock protein beta-1

2

6

High-throughput

0.571

High

550133

PABP1
Polyadenylate-binding protein 1

2

3

High-throughput

0.571

High

576291

HNRPL
Heterogeneous nuclear ribonucleoprotein L

2

9

High-throughput

0.571

High

587564

DESP
Desmoplakin

2

7

High-throughput

0.571

High

685411

U2AF2
Splicing factor U2AF 65 kDa subunit

2

6

High-throughput

0.571

High

687331

PTBP1
Polypyrimidine tract-binding protein 1

2

9

High-throughput

0.571

High

703914

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

2

7

High-throughput

0.571

High

703925

HNRPK
Heterogeneous nuclear ribonucleoprotein K

2

9

High-throughput

0.571

High

703931

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

2

3

High-throughput

0.571

High

703933

ILF2
Interleukin enhancer-binding factor 2

2

1

High-throughput

0.571

High

703936

PABP4
Polyadenylate-binding protein 4

2

3

High-throughput

0.571

High

703939

CAPR1
Caprin-1

2

2

High-throughput

0.571

High

703941

PCBP2
Poly(rC)-binding protein 2

2

6

High-throughput

0.571

High

703956

PABP2
Polyadenylate-binding protein 2

2

4

High-throughput

0.571

High

703958

RB6I2
ELKS/Rab6-interacting/CAST family member 1

2

7

High-throughput

0.571

High

703959

SRRM1
Serine/arginine repetitive matrix protein 1

2

2

High-throughput

0.571

High

703960

CCAR2
Cell cycle and apoptosis regulator protein 2

2

2

High-throughput

0.571

High

703964

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

2

9

High-throughput

0.571

High

703975

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

2

6

High-throughput

0.571

High

703977

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

2

6

High-throughput

0.571

High

703978

PABP3
Polyadenylate-binding protein 3

2

3

High-throughput

0.571

High

703986

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

2

10

High-throughput

0.571

High

703985

AMFR
E3 ubiquitin-protein ligase AMFR

1

1

Small-scale

0.561

High

703965

ASB11
Ankyrin repeat and SOCS box protein 11

1

5

High-throughput

0.553

High

703922

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

0

High-throughput

0.547

High

703926

YBOX1
Y-box-binding protein 1

2

0

High-throughput

0.547

High

703932

NCBP1
Nuclear cap-binding protein subunit 1

2

0

High-throughput

0.547

High

703949

LARP1
La-related protein 1

2

0

High-throughput

0.547

High

703953

DHX30
ATP-dependent RNA helicase DHX30

2

0

High-throughput

0.547

High

703957

LYRIC
Protein LYRIC

2

0

High-throughput

0.547

High

703929

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.541

High

703927

RT35
Small ribosomal subunit protein mS35

2

2

High-throughput

0.521

High

703928

TIAR
Nucleolysin TIAR

1

4

Small-scale

0.515

High

703944

HSPB2
Heat shock protein beta-2

1

6

High-throughput

0.508

High

529150

TAU
Microtubule-associated protein tau

1

1

Small-scale

0.501

High

703950

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.494

High

703984

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

1

High-throughput

0.494

High

124580

EYA2
Protein phosphatase EYA2

1

1

High-throughput

0.479

High

403844

GCR
Glucocorticoid receptor

1

3

Small-scale

0.479

High

459870

APT
Adenine phosphoribosyltransferase

1

2

High-throughput

0.479

High

610997

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

6

High-throughput

0.479

High

666070

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

1

High-throughput

0.479

High

680784

PSA1
Proteasome subunit alpha type-1

1

1

High-throughput

0.479

High

703911

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

4

Small-scale

0.479

High

703912

HSP74
Heat shock 70 kDa protein 4

1

9

Small-scale

0.479

High

703945

NF2L2
Nuclear factor erythroid 2-related factor 2

1

1

Small-scale

0.479

High

703951

UBR3
E3 ubiquitin-protein ligase UBR3

1

1

Small-scale

0.479

High

703952

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

3

Small-scale

0.479

High

703963

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

9

Small-scale

0.479

High

703971

ABHEB
Putative protein-lysine deacylase ABHD14B

1

2

High-throughput

0.479

High

703972

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

703973

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

2

High-throughput

0.479

High

703974

PARK7
Parkinson disease protein 7

1

5

High-throughput

0.479

High

703976

MTMRC
Myotubularin-related protein 12

1

2

High-throughput

0.479

High

606277

CEBPB
CCAAT/enhancer-binding protein beta

1

0

Small-scale

0.458

High

703930

UBE3A
Ubiquitin-protein ligase E3A

1

0

Small-scale

0.458

High

703940

SNX17
Sorting nexin-17

1

0

High-throughput

0.458

High

703962

PAF1
RNA polymerase II-associated factor 1 homolog

1

0

Small-scale

0.458

High

703969

FBX32
F-box only protein 32

1

0

Small-scale

0.458

High

703983

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

0

High-throughput

0.458

High

507091

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

3

Small-scale

0.445

High

703938

CUL1
Cullin-1

1

3

Small-scale

0.445

High

559875

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

3

High-throughput

0.437

High

624544

SPEE
Spermidine synthase

1

5

High-throughput

0.437

High

703910

METK2
S-adenosylmethionine synthase isoform type-2

1

1

High-throughput

0.437

High

703920

BIEA
Biliverdin reductase A

1

1

High-throughput

0.437

High

703924

COPZ1
Coatomer subunit zeta-1

1

7

High-throughput

0.437

High

703947

SGMR2
Sigma intracellular receptor 2

1

2

High-throughput

0.437

High

703954

HDDC2
5'-deoxynucleotidase HDDC2

1

2

High-throughput

0.437

High

703955

TRI46
Tripartite motif-containing protein 46

1

6

Small-scale

0.437

High

703967

AP3S1
AP-3 complex subunit sigma-1

1

7

High-throughput

0.437

High

703980

ECHD1
Ethylmalonyl-CoA decarboxylase

1

1

High-throughput

0.437

High

271020

PTCD1
Pentatricopeptide repeat-containing protein 1, mitochondrial

2

0

High-throughput

0.298

High

350795

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

2

0

High-throughput

0.298

High

703917

RT29
Small ribosomal subunit protein mS29

2

0

High-throughput

0.298

High

703919

SSRD
Translocon-associated protein subunit delta

2

0

High-throughput

0.298

High

703923

CKS1
Cyclin-dependent kinases regulatory subunit 1

2

0

Small-scale

0.298

High

703937

RM49
Large ribosomal subunit protein mL49

2

0

High-throughput

0.298

High

703948

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

2

0

High-throughput

0.298

High

703961

RM50
Large ribosomal subunit protein mL50

2

0

High-throughput

0.298

High

703968

RT31
Small ribosomal subunit protein mS31

2

0

High-throughput

0.298

High

703979

RM17
Large ribosomal subunit protein bL17m

2

0

High-throughput

0.298

High

703981

DDX28
Probable ATP-dependent RNA helicase DDX28

2

0

High-throughput

0.298

High

703982

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

2

0

High-throughput

0.298

High

703970

STALP
AMSH-like protease

1

0

Small-scale

0.292

High

254272

ICMT
Protein-S-isoprenylcysteine O-methyltransferase

1

0

High-throughput

0.249

Low

703966

RTF1
RNA polymerase-associated protein RTF1 homolog

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025