Protein: IDHC
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (IDH1) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDPc) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)

Gene: IDHC, IDH1
Organism: Homo sapiens
Interactions: 66
UniProt ID: O75874

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004450 - isocitrate dehydrogenase (NADP+) activity
GO:0005576 - extracellular region
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

276619

IDHC
Isocitrate dehydrogenase [NADP] cytoplasmic

4

1

Small-scale

0.884

High

226083

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

276620

AGR2
Anterior gradient protein 2 homolog

2

1

Small-scale

0.584

High

276676

SHOC2
Leucine-rich repeat protein SHOC-2

2

1

High-throughput

0.571

High

276624

CALM1
Calmodulin-1

1

0

Small-scale

0.564

High

276623

CDK1
Cyclin-dependent kinase 1

1

3

Small-scale

0.561

High

276644

PLK1
Serine/threonine-protein kinase PLK1

1

2

Small-scale

0.561

High

276664

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.547

High

276654

FIGL1
Fidgetin-like protein 1

1

4

High-throughput

0.541

High

276638

NUP62
Nuclear pore glycoprotein p62

1

0

High-throughput

0.518

High

276660

LAX1
Lymphocyte transmembrane adapter 1

1

0

High-throughput

0.518

High

276662

AGGF1
Angiogenic factor with G patch and FHA domains 1

1

0

High-throughput

0.518

High

276668

UBL7
Ubiquitin-like protein 7

1

0

High-throughput

0.518

High

276634

CALR
Calreticulin

1

1

High-throughput

0.515

High

276637

TGFR2
TGF-beta receptor type-2

1

1

High-throughput

0.515

High

276647

UBE3A
Ubiquitin-protein ligase E3A

1

1

High-throughput

0.515

High

276622

P53
Cellular tumor antigen p53

1

0

High-throughput

0.513

High

276678

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

0

High-throughput

0.513

High

276680

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

276630

PECA1
Platelet endothelial cell adhesion molecule

1

0

High-throughput

0.493

High

276631

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

0

High-throughput

0.493

High

276636

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.493

High

276666

NEK7
Serine/threonine-protein kinase Nek7

1

0

High-throughput

0.493

High

276621

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

276627

CADH1
Cadherin-1

1

1

High-throughput

0.479

High

276628

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

1

High-throughput

0.479

High

276632

CDK2
Cyclin-dependent kinase 2

1

3

High-throughput

0.479

High

276640

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

276645

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

276655

TRI65
E3 ubiquitin-protein ligase TRIM65

1

2

Small-scale

0.479

High

276656

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

276658

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

276667

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

276670

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

276673

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

276674

UBQL2
Ubiquilin-2

1

2

High-throughput

0.479

High

276677

FND3A
Fibronectin type-III domain-containing protein 3A

1

1

High-throughput

0.479

High

127959

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

0

High-throughput

0.458

High

135323

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

0

High-throughput

0.458

High

276626

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

276639

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

276641

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

276648

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

High-throughput

0.458

High

276652

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

276659

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

276625

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

276653

PKHA7
Pleckstrin homology domain-containing family A member 7

1

3

High-throughput

0.445

High

276661

CE57L
Centrosomal protein CEP57L1

1

0

High-throughput

0.438

High

276629

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

276633

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

276635

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

276646

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.437

High

276651

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

276649

CUL3
Cullin-3

1

0

High-throughput

0.426

High

276643

PEX5
Peroxisomal targeting signal 1 receptor

1

0

Small-scale

0.391

High

276650

FHL2
Four and a half LIM domains protein 2

1

0

High-throughput

0.282

High

276657

F131A
Protein FAM131A

1

0

High-throughput

0.282

High

276663

EFC4A
EF-hand calcium-binding domain-containing protein 4A

1

0

High-throughput

0.282

High

276669

PRD14
PR domain zinc finger protein 14

1

0

High-throughput

0.282

High

276671

TMOD4
Tropomodulin-4

1

0

High-throughput

0.282

High

276672

DKK3
Dickkopf-related protein 3

1

0

High-throughput

0.282

High

276675

ZHX1
Zinc fingers and homeoboxes protein 1

1

0

High-throughput

0.282

High

276665

ATLA2
Atlastin-2

1

0

High-throughput

0.279

Low

276642

SERPH
Serpin H1

1

0

High-throughput

0.268

Low

276679

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024