HitPredict

Interactor 1: BRE1B (O75150)
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)
Gene: RNF40

Interactor 2: PRP19 (Q9UMS4)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)
Gene: PRPF19

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1001 Hs			1 504
+	Hs
		1138236 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		PRP19_HUMAN (1-504): 2.85e-165: 479: 100.00
+	Hs
		149418 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		PRP19_HUMAN (1-504): 2.85e-165: 479: 100.00
+	Hs
		724952 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		FBXW7_HUMAN (88-458): 1.1e-73: 248: 18.06
+	Hs
		725215 MYH10_HUMAN (1-443): 3.14e-19: 96.3: 12.58		FBXW7_HUMAN (88-458): 1.1e-73: 248: 18.06
+	Hs
		728492 MYH11_HUMAN (563-983): 2.12e-18: 93.6: 10.66		POC1A_HUMAN (88-377): 5.18e-64: 215: 20.68
+	Sc
		744703 BRE1_YEAST (506-1000): 2.2e-57: 212: 18.77		TAF5_YEAST (233-436): 1.2e-18: 91.3: 27.81
+	Hs
		149156 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		SNR40_HUMAN (298-504): 7e-58: 197: 21.91
+	Hs
		551632 DESP_HUMAN (233-945): 1.26e-09: 64.9: 14.36		LIS1_HUMAN (302-504): 3.93e-56: 194: 19.11
+	Hs
		148157 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		PRP4_HUMAN (308-504): 2.63e-48: 176: 18.84
+	Hs
		148610 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Hs
		551655 DESP_HUMAN (233-945): 1.26e-09: 64.9: 14.36		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Hs
		551766 DESP_HUMAN (233-945): 1.26e-09: 64.9: 14.36		WDR5B_HUMAN (89-333): 1.53e-40: 150: 16.60
+	Hs
		551854 DESP_HUMAN (233-945): 1.26e-09: 64.9: 14.36		NLE1_HUMAN (93-333): 6.85e-38: 146: 14.86
+	Hs
		148858 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		TAF5_HUMAN (233-434): 3.88e-16: 83.6: 26.60