HitPredict

Interactor 1: LRP5 (O75197)
Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)
Gene: LRP5

Interactor 2: KLK15 (Q9H2R5)
Kallikrein-15 (EC 3.4.21.-) (ACO protease)
Gene: KLK15

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FXa_inhibition~Trypsin, Ldl_recept_a~Trypsin
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1615 Hs			1 256
+	Hs
		258288 LRP5_HUMAN (27-1615): 0: 1840: 100.00		KLK3_HUMAN (1-256): 3.21e-104: 304: 40.00
+	Hs
		258362 LRP5_HUMAN (27-1615): 0: 1840: 100.00		KLK5_HUMAN (13-256): 5.32e-98: 290: 41.46
+	Hs
		270327 LRP6_HUMAN (8-646): 0: 590: 37.98		KLK15_HUMAN (1-256): 3.74e-114: 329: 100.00
+	Hs
		270263 LRP6_HUMAN (8-646): 0: 590: 37.98		KLK2_HUMAN (1-256): 2.8e-108: 314: 39.63
+	Hs
		270253 LRP6_HUMAN (8-646): 0: 590: 37.98		KLK3_HUMAN (1-256): 3.21e-104: 304: 40.00
+	Hs
		270350 LRP6_HUMAN (8-646): 0: 590: 37.98		KLK5_HUMAN (13-256): 5.32e-98: 290: 41.46
+	Hs
		351104 LDLR_HUMAN (1182-1295): 3.76e-11: 70.1: 19.30		KLK15_HUMAN (1-256): 3.74e-114: 329: 100.00
+	Hs
		409510 VLDLR_HUMAN (1364-1613): 1.52e-10: 68.2: 10.82		HEPS_HUMAN (4-254): 5.24e-98: 294: 30.55
+	Hs
		351117 LDLR_HUMAN (1182-1295): 3.76e-11: 70.1: 19.30		KLK5_HUMAN (13-256): 5.32e-98: 290: 41.46
+	Mm
		371501 NID1_MOUSE (1182-1344): 3.07e-15: 84: 11.43		CFAD_MOUSE (12-256): 1.1e-45: 155: 37.40
+	Mm
		372321 LRP1_MOUSE (1216-1381): 6.04e-10: 66.6: 19.32		CFAD_MOUSE (12-256): 1.1e-45: 155: 37.40