HitPredict

Interactor 1: FKBP6 (O75344)
Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (Inactive PPIase FKBP6) (36 kDa FK506-binding protein) (36 kDa FKBP) (FKBP-36) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36)
Gene: FKBP6

Interactor 2: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25036637
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FKBP_C~HSP90
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006457 - protein folding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 327 Hs			1 732
+	Hs
		111930 FKBP6_HUMAN (1-327): 4.19e-82: 253: 100.00		K9JA46_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		111936 FKBP4_HUMAN (2-327): 4.29e-73: 234: 23.33		K9JA46_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		431755 FKBP4_HUMAN (2-327): 4.29e-73: 234: 23.33		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Mm
		432409 FKBP4_MOUSE (2-327): 6.15e-73: 234: 23.64		HS90A_MOUSE (1-732): 0: 1083: 97.82
+	Hs
		259915 FKBP6_HUMAN (1-327): 4.19e-82: 253: 100.00		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		111937 FKBP5_HUMAN (2-327): 2.72e-66: 216: 22.73		K9JA46_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		431818 FKBP5_HUMAN (2-327): 2.72e-66: 216: 22.73		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		438089 FKBP4_HUMAN (2-327): 4.29e-73: 234: 23.33		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		431850 FKBP8_HUMAN (1-319): 8.64e-60: 198: 23.80		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		432312 AIPL1_HUMAN (36-317): 4.56e-56: 188: 17.90		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		438136 FKBP5_HUMAN (2-327): 2.72e-66: 216: 22.73		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		111929 AIP_HUMAN (33-316): 2.17e-53: 180: 17.39		K9JA46_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		118674 AIP_HUMAN (33-316): 2.17e-53: 180: 17.39		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		438169 FKBP8_HUMAN (1-319): 8.64e-60: 198: 23.80		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		111943 FKBPL_HUMAN (8-316): 4.28e-48: 166: 18.10		K9JA46_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		118678 AIP_HUMAN (33-316): 2.17e-53: 180: 17.39		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	At
		646592 FKB42_ARATH (7-327): 6.66e-63: 205: 25.38		HS901_ARATH (15-732): 0: 981: 69.49
+	Ce
		220015 O45418_CAEEL (2-324): 1.82e-59: 198: 20.12		HSP90_CAEEL (14-732): 0: 960: 74.83
+	Hs
		972520 FKBP4_HUMAN (2-327): 4.29e-73: 234: 23.33		H90B4_HUMAN (30-604): 0: 571: 62.61
+	Hs
		1053004 FKBP8_HUMAN (1-319): 8.64e-60: 198: 23.80		H90B4_HUMAN (30-604): 0: 571: 62.61