Protein: CIRBP
Cold-inducible RNA-binding protein (A18 hnRNP) (Glycine-rich RNA-binding protein CIRP)

Gene: CIRBP
Organism: Homo sapiens
Interactions: 148
UniProt ID: Q14011

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003730 - mRNA 3'-UTR binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005681 - spliceosomal complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

794479

RBMX
RNA-binding motif protein, X chromosome

2

15

High-throughput

0.834

High

1120012

TNPO3
Transportin-3

2

9

High-throughput

0.811

High

478038

SNRPA
U1 small nuclear ribonucleoprotein A

2

18

High-throughput

0.811

High

485134

ROA1
Heterogeneous nuclear ribonucleoprotein A1

2

20

High-throughput

0.789

High

1016437

SRSF3
Serine/arginine-rich splicing factor 3

2

20

High-throughput

0.783

High

515838

RBY1A
RNA-binding motif protein, Y chromosome, family 1 member A1

1

17

High-throughput

0.740

High

1119943

RBY1F
RNA-binding motif protein, Y chromosome, family 1 member F/J

1

17

High-throughput

0.740

High

965671

HNRPK
Heterogeneous nuclear ribonucleoprotein K

6

20

High-throughput

0.739

High

997706

CSK21
Casein kinase II subunit alpha

1

10

High-throughput

0.710

High

1119988

ANM1
Protein arginine N-methyltransferase 1

4

16

Small-scale

0.697

High

650548

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

10

High-throughput

0.691

High

919954

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.691

High

1115639

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

15

High-throughput

0.691

High

1119989

MEP50
Methylosome protein WDR77

3

14

High-throughput

0.667

High

1096306

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

19

High-throughput

0.656

High

396084

ESR1
Estrogen receptor

3

20

Small-scale

0.641

High

162567

ANM5
Protein arginine N-methyltransferase 5

2

16

High-throughput

0.628

High

1119985

ANM6
Protein arginine N-methyltransferase 6

2

16

High-throughput

0.628

High

1119990

RIOK1
Serine/threonine-protein kinase RIO1

2

5

High-throughput

0.628

High

1119993

RM01
Large ribosomal subunit protein uL1m

2

1

High-throughput

0.628

High

1120000

NGRN
Neugrin

2

4

High-throughput

0.628

High

1120008

PAI2B
Polyadenylate-binding protein-interacting protein 2B

2

11

High-throughput

0.628

High

1120010

SYYM
Tyrosine--tRNA ligase, mitochondrial

2

2

High-throughput

0.628

High

1119953

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

2

18

High-throughput

0.628

High

927290

ATX1
Ataxin-1

2

2

High-throughput

0.620

High

400814

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

12

High-throughput

0.618

High

472729

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

17

High-throughput

0.618

High

1087654

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

7

High-throughput

0.618

High

1119938

CIRBP
Cold-inducible RNA-binding protein

1

18

High-throughput

0.618

High

1119944

SF3A2
Splicing factor 3A subunit 2

1

8

High-throughput

0.618

High

1119948

LARP7
La-related protein 7

1

20

High-throughput

0.618

High

1119978

REQU
Zinc finger protein ubi-d4

1

17

High-throughput

0.618

High

1120006

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.618

High

926176

ICLN
Methylosome subunit pICln

2

0

High-throughput

0.602

High

1120001

COPRS
Coordinator of PRMT5 and differentiation stimulator

2

0

High-throughput

0.602

High

529772

TAU
Microtubule-associated protein tau

2

15

High-throughput

0.601

High

371992

MYC
Myc proto-oncogene protein

2

19

High-throughput

0.584

High

943940

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.575

High

1119968

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.575

High

1119983

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

2

1

High-throughput

0.574

High

1119972

LNX1
E3 ubiquitin-protein ligase LNX

1

3

High-throughput

0.573

High

765496

BMI1
Polycomb complex protein BMI-1

2

20

High-throughput

0.571

High

1119960

RHG22
Rho GTPase-activating protein 22

2

3

High-throughput

0.571

High

1119996

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.553

High

1005424

SERB
Phosphoserine phosphatase

2

0

High-throughput

0.551

High

105908

APRIO
Alternative prion protein

2

4

Small-scale

0.543

High

1120007

BAG5
BAG family molecular chaperone regulator 5

1

3

High-throughput

0.541

High

140909

NOP56
Nucleolar protein 56

1

3

High-throughput

0.536

High

342178

BRD1
Bromodomain-containing protein 1

1

7

High-throughput

0.536

High

521344

ARAF
Serine/threonine-protein kinase A-Raf

1

13

High-throughput

0.536

High

1112475

CUL1
Cullin-1

1

20

High-throughput

0.536

High

1112830

CUL2
Cullin-2

1

20

High-throughput

0.536

High

1113067

CUL3
Cullin-3

1

20

High-throughput

0.536

High

1119945

NEDD8
Ubiquitin-like protein NEDD8

1

3

High-throughput

0.536

High

1119952

ANGE2
Protein angel homolog 2

1

1

High-throughput

0.536

High

1119955

KDM4D
Lysine-specific demethylase 4D

1

2

High-throughput

0.536

High

1119963

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

13

High-throughput

0.536

High

1119965

FABD
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

1

2

High-throughput

0.536

High

1119970

TDRD7
Tudor domain-containing protein 7

1

9

High-throughput

0.536

High

1119971

WDR48
WD repeat-containing protein 48

1

15

High-throughput

0.536

High

1119979

CSN5
COP9 signalosome complex subunit 5

1

9

High-throughput

0.536

High

1119980

CUL5
Cullin-5

1

20

High-throughput

0.536

High

1120005

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

8

High-throughput

0.536

High

549321

SRF
Serum response factor

1

0

High-throughput

0.518

High

899746

PAPOA
Poly(A) polymerase alpha

1

0

High-throughput

0.513

High

1104307

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.513

High

1119998

B2L12
Bcl-2-like protein 12

1

0

High-throughput

0.513

High

1059832

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

18

High-throughput

0.508

High

404786

PRIO
Major prion protein

1

2

Small-scale

0.501

High

422089

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

507952

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

15

High-throughput

0.501

High

1120011

FBX7
F-box only protein 7

1

2

High-throughput

0.501

High

776189

SOX6
Transcription factor SOX-6

1

13

High-throughput

0.500

High

1119974

BRX1
Ribosome biogenesis protein BRX1 homolog

1

0

High-throughput

0.493

High

1119991

LXN
Latexin

1

0

High-throughput

0.493

High

1119982

MTEF3
Transcription termination factor 3, mitochondrial

1

3

High-throughput

0.489

High

1120002

ANM8
Protein arginine N-methyltransferase 8

1

15

High-throughput

0.489

High

241643

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.479

High

252348

TLR2
Toll-like receptor 2

1

2

Small-scale

0.479

High

254365

CC14B
Dual specificity protein phosphatase CDC14B

1

7

High-throughput

0.479

High

272155

OBSL1
Obscurin-like protein 1

1

10

High-throughput

0.479

High

315578

RECQ4
ATP-dependent DNA helicase Q4

1

20

High-throughput

0.479

High

317174

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

4

High-throughput

0.479

High

319752

UFL1
E3 UFM1-protein ligase 1

1

5

High-throughput

0.479

High

324852

HEXI1
Protein HEXIM1

1

7

High-throughput

0.479

High

335123

ARI2
E3 ubiquitin-protein ligase ARIH2

1

20

High-throughput

0.479

High

363265

EGFR
Epidermal growth factor receptor

1

5

High-throughput

0.479

High

406164

MYCN
N-myc proto-oncogene protein

1

19

High-throughput

0.479

High

482471

F16P1
Fructose-1,6-bisphosphatase 1

1

4

High-throughput

0.479

High

766541

PHB1
Prohibitin 1

1

9

High-throughput

0.479

High

904696

MECP2
Methyl-CpG-binding protein 2

1

8

High-throughput

0.479

High

937746

FOXA1
Hepatocyte nuclear factor 3-alpha

1

6

High-throughput

0.479

High

951669

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.479

High

964935

WDR5
WD repeat-containing protein 5

1

9

High-throughput

0.479

High

967149

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

4

High-throughput

0.479

High

1024568

VIGLN
Vigilin

1

20

High-throughput

0.479

High

1088833

TP53B
TP53-binding protein 1

1

5

High-throughput

0.479

High

1092123

NFX1
Transcriptional repressor NF-X1

1

5

High-throughput

0.479

High

1115185

CUL4B
Cullin-4B

1

20

High-throughput

0.479

High

1119939

RHG19
Rho GTPase-activating protein 19

1

4

High-throughput

0.479

High

1119940

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1119941

RAGE
Advanced glycosylation end product-specific receptor

1

5

Small-scale

0.479

High

1119946

EZH2
Histone-lysine N-methyltransferase EZH2

1

13

High-throughput

0.479

High

1119947

E2F4
Transcription factor E2F4

1

2

High-throughput

0.479

High

1119951

RC3H1
Roquin-1

1

14

High-throughput

0.479

High

1119954

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1119957

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1119958

PAXI1
PAX-interacting protein 1

1

13

High-throughput

0.479

High

1119959

MEPCE
7SK snRNA methylphosphate capping enzyme

1

9

High-throughput

0.479

High

1119961

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

7

High-throughput

0.479

High

1119962

ZCH18
Zinc finger CCCH domain-containing protein 18

1

11

High-throughput

0.479

High

1119964

MF2L2
Probable guanine nucleotide exchange factor MCF2L2

1

2

High-throughput

0.479

High

1119966

DOCK3
Dedicator of cytokinesis protein 3

1

1

High-throughput

0.479

High

1119967

CMTR1
Cap-specific mRNA

1

2

High-throughput

0.479

High

1119973

WDR20
WD repeat-containing protein 20

1

10

High-throughput

0.479

High

1119975

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

5

High-throughput

0.479

High

1119976

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

1119977

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1119984

DDRGK
DDRGK domain-containing protein 1

1

6

High-throughput

0.479

High

1119986

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.479

High

1119987

BARD1
BRCA1-associated RING domain protein 1

1

8

High-throughput

0.479

High

1119992

DUS23
Dual specificity protein phosphatase 23

1

12

High-throughput

0.479

High

1119997

NANOG
Homeobox protein NANOG

1

6

High-throughput

0.479

High

1119999

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

7

High-throughput

0.479

High

1120003

RHG35
Rho GTPase-activating protein 35

1

3

High-throughput

0.479

High

1120004

LYAR
Cell growth-regulating nucleolar protein

1

1

High-throughput

0.479

High

1120009

FZR1
Fizzy-related protein homolog

1

18

High-throughput

0.479

High

1120013

MAFB
Transcription factor MafB

1

9

High-throughput

0.479

High

1119950

HABP4
Intracellular hyaluronan-binding protein 4

1

3

Small-scale

0.457

High

429868

JUN
Transcription factor Jun

1

12

High-throughput

0.445

High

1056717

FMR1
Fragile X messenger ribonucleoprotein 1

1

7

High-throughput

0.445

High

1119117

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

9

High-throughput

0.445

High

1119949

NCBP3
Nuclear cap-binding protein subunit 3

1

6

High-throughput

0.445

High

51075

PKHG3
Pleckstrin homology domain-containing family G member 3

1

11

High-throughput

0.437

High

318767

RHBT1
Rho-related BTB domain-containing protein 1

1

17

High-throughput

0.437

High

336953

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

1

Small-scale

0.437

High

377570

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

389351

FINC
Fibronectin

1

11

High-throughput

0.437

High

1116197

PTC1
Protein patched homolog 1

1

1

Small-scale

0.437

High

1119956

PKHG7
Pleckstrin homology domain-containing family G member 7

1

2

High-throughput

0.437

High

1119969

NGEF
Ephexin-1

1

10

High-throughput

0.437

High

1119981

CHM4C
Charged multivesicular body protein 4c

1

13

High-throughput

0.437

High

1119994

DOCK9
Dedicator of cytokinesis protein 9

1

4

High-throughput

0.437

High

886845

CEBPA
CCAAT/enhancer-binding protein alpha

1

13

High-throughput

0.408

High

619786

VCAM1
Vascular cell adhesion protein 1

1

13

High-throughput

0.407

High

1119995

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.407

High

1119942

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025