HitPredict

Interactor 1: FKBP6 (O75344)
Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (Inactive PPIase FKBP6) (36 kDa FK506-binding protein) (36 kDa FKBP) (FKBP-36) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36)
Gene: FKBP6

Interactor 2: PDE4A (P27815)
3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A)
Gene: PDE4A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 327 Hs			1 886
+	Rn
		872397 AIP_RAT (33-316): 5.76e-52: 176: 16.77		PDE4A_RAT (1-885): 0: 1253: 80.36
+	Hs
		118730 AIP_HUMAN (33-316): 2.17e-53: 180: 17.39		PDE7A_HUMAN (319-708): 1.88e-136: 417: 29.70
+	Hs
		283088 AIPL1_HUMAN (36-317): 4.56e-56: 188: 17.90		PDE5A_HUMAN (371-696): 1.05e-120: 388: 26.14
+	Hs
		1032770 FKBP8_HUMAN (1-319): 8.64e-60: 198: 23.80		PDE3B_HUMAN (369-657): 8.01e-43: 171: 32.64
+	Hs
		118735 AIP_HUMAN (33-316): 2.17e-53: 180: 17.39		PDE3A_HUMAN (369-657): 1e-40: 164: 32.64
+	Rn
		963099 AIP_RAT (33-316): 5.76e-52: 176: 16.77		PDE2A_RAT (398-677): 8.72e-35: 145: 30.25