Protein: SUB2
ATP-dependent RNA helicase SUB2 (EC 3.6.4.13) (Suppressor of BRR1 protein 2)

Gene: SUB2
Organism: Saccharomyces cerevisiae S288C
Interactions: 142
UniProt ID: Q07478

Gene Ontology (top 5):
GO:0000346 - transcription export complex
GO:0000398 - mRNA splicing, via spliceosome
GO:0000781 - chromosome, telomeric region
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

921198

THO2
THO complex subunit 2

4

9

Small-scale

0.892

High

923910

TEX1
Protein TEX1

3

14

Small-scale

0.847

High

594594

RPB3
DNA-directed RNA polymerase II subunit RPB3

3

3

Small-scale

0.827

High

817433

THO1
Protein THO1

2

1

High-throughput

0.801

High

1059469

SUB2
ATP-dependent RNA helicase SUB2

2

17

High-throughput

0.800

High

1059477

YRA1
RNA annealing protein YRA1

9

20

Small-scale

0.758

High

757546

NCBP1
Nuclear cap-binding protein complex subunit 1

2

6

Small-scale

0.754

High

605931

HPR1
THO complex subunit HPR1

11

0

Small-scale

0.727

High

753267

MFT1
THO complex subunit MFT1

7

0

Small-scale

0.711

High

150190

THP2
THO complex subunit THP2

5

0

Small-scale

0.684

High

738933

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

3

4

Small-scale

0.650

High

779935

YRA2
RNA annealing protein YRA2

3

0

Small-scale

0.641

High

393416

HSP82
ATP-dependent molecular chaperone HSP82

3

9

High-throughput

0.633

High

470602

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.618

High

518403

IF4A
ATP-dependent RNA helicase eIF4A

1

19

High-throughput

0.618

High

632828

DBP5
ATP-dependent RNA helicase DBP5

1

18

High-throughput

0.618

High

664624

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

1

9

High-throughput

0.618

High

812126

DHH1
ATP-dependent RNA helicase DHH1

1

18

High-throughput

0.618

High

874555

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.618

High

1044479

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.618

High

1059476

RRP6
Exosome complex exonuclease RRP6

1

3

High-throughput

0.618

High

1059480

DBP10
ATP-dependent RNA helicase DBP10

1

19

High-throughput

0.618

High

676775

GBP2
Serine/arginine

2

17

Small-scale

0.611

High

858364

SAC3
Nuclear mRNA export protein SAC3

2

3

Small-scale

0.601

High

1031060

NOP3
Serine/arginine

2

20

Small-scale

0.600

High

1059479

SMT3
Ubiquitin-like protein SMT3

2

7

High-throughput

0.600

High

580150

HSC82
ATP-dependent molecular chaperone HSC82

2

9

High-throughput

0.584

High

850223

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

15

High-throughput

0.584

High

794007

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

15

High-throughput

0.575

High

821991

PSA6
Proteasome subunit alpha type-6

1

4

Small-scale

0.541

High

1052934

MDM30
Mitochondrial distribution and morphology protein 30

1

0

Small-scale

0.537

High

763033

SPT7
SAGA complex subunit SPT7

1

13

High-throughput

0.536

High

801987

KIC1
Serine/threonine-protein kinase KIC1

1

5

High-throughput

0.536

High

893347

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

7

High-throughput

0.536

High

923136

BRE5
UBP3-associated protein BRE5

1

8

High-throughput

0.536

High

1036348

ADA2
SAGA complex subunit ADA2

1

4

High-throughput

0.536

High

1042384

GCN5
Histone acetyltransferase GCN5

1

17

High-throughput

0.536

High

1046944

POB3
FACT complex subunit POB3

2

6

Small-scale

0.533

High

916607

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

0

High-throughput

0.513

High

381290

H2B1
Histone H2B.1

1

10

High-throughput

0.479

High

381652

H2B2
Histone H2B.2

1

10

High-throughput

0.479

High

382378

H4
Histone H4

1

5

High-throughput

0.479

High

386879

TBB
Tubulin beta chain

1

8

High-throughput

0.479

High

402132

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

7

High-throughput

0.479

High

403671

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

16

Small-scale

0.479

High

404991

PUR3
Phosphoribosylglycinamide formyltransferase

1

1

High-throughput

0.479

High

419520

H2A1
Histone H2A.1

1

4

High-throughput

0.479

High

419890

H2A2
Histone H2A.2

1

4

High-throughput

0.479

High

435393

RS3
Small ribosomal subunit protein uS3

1

5

High-throughput

0.479

High

442134

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.479

High

455289

RS19A
Small ribosomal subunit protein eS19A

1

5

High-throughput

0.479

High

525311

HSP71
Heat shock protein SSA1

1

13

High-throughput

0.479

High

531409

METK1
S-adenosylmethionine synthase 1

1

3

High-throughput

0.479

High

536177

ARF1
ADP-ribosylation factor 1

1

3

High-throughput

0.479

High

548731

RNA1
Ran GTPase-activating protein 1

1

6

High-throughput

0.479

High

558876

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.479

High

585734

UBC4
Ubiquitin-conjugating enzyme E2 4

1

2

High-throughput

0.479

High

616456

SEC18
Vesicular-fusion protein SEC18

1

9

High-throughput

0.479

High

642481

MCK1
Protein kinase MCK1

1

11

High-throughput

0.479

High

649247

SAN1
Protein SAN1

1

1

Small-scale

0.479

High

671174

SIS1
Protein SIS1

1

6

High-throughput

0.479

High

674861

RS2
Small ribosomal subunit protein uS5

1

7

High-throughput

0.479

High

680103

CDC48
Cell division control protein 48

1

8

High-throughput

0.479

High

701741

URA7
CTP synthase 1

1

5

High-throughput

0.479

High

708327

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

727354

HS104
Heat shock protein 104

1

5

High-throughput

0.479

High

735188

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

737955

HOG1
Mitogen-activated protein kinase HOG1

1

10

High-throughput

0.479

High

741146

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

20

High-throughput

0.479

High

750791

PRS6A
26S proteasome regulatory subunit 6A

1

5

High-throughput

0.479

High

760628

TSA1
Peroxiredoxin TSA1

1

5

Small-scale

0.479

High

778560

RS27A
Small ribosomal subunit protein eS27A

1

4

High-throughput

0.479

High

793662

ARL1
ADP-ribosylation factor-like protein 1

1

6

High-throughput

0.479

High

796130

IMB2
Importin subunit beta-2

1

6

High-throughput

0.479

High

801796

KPR3
Ribose-phosphate pyrophosphokinase 3

1

1

High-throughput

0.479

High

803701

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

805758

YHS7
Uncharacterized protein YHR127W

1

1

Small-scale

0.479

High

806825

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

807696

HRB1
Serine/arginine

1

17

Small-scale

0.479

High

811242

PCF11
Protein PCF11

1

2

Small-scale

0.479

High

824800

MLP2
Protein MLP2

1

13

High-throughput

0.479

High

825634

AIR1
Protein AIR1

1

6

Small-scale

0.479

High

836920

MPG1
Mannose-1-phosphate guanyltransferase

1

3

High-throughput

0.479

High

874235

TRF5
Poly(A) RNA polymerase protein 1

1

5

Small-scale

0.479

High

918703

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

919015

PESC
Pescadillo homolog

1

2

High-throughput

0.479

High

919404

RBG2
Ribosome-interacting GTPase 2

1

7

High-throughput

0.479

High

924196

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

12

High-throughput

0.479

High

963753

H3
Histone H3

1

10

High-throughput

0.479

High

1033593

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

1034641

MTD1
Methylenetetrahydrofolate dehydrogenase [NAD(+)]

1

3

High-throughput

0.479

High

1038759

XRN2
5'-3' exoribonuclease 2

1

3

Small-scale

0.479

High

1040554

ESP1
Separin

1

1

High-throughput

0.479

High

1044568

CTK1
CTD kinase subunit alpha

1

14

Small-scale

0.479

High

1051190

SYRC
Arginine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

1053927

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

1054852

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.479

High

1059470

THP1
Nuclear mRNA export protein THP1

1

3

Small-scale

0.479

High

1059471

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.479

High

1059474

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

1059478

RIO1
Serine/threonine-protein kinase RIO1

1

7

High-throughput

0.479

High

1059481

AHA1
Hsp90 co-chaperone AHA1

1

2

High-throughput

0.479

High

553663

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.458

High

577378

MTF1
Mitochondrial transcription factor 1

1

0

Small-scale

0.458

High

636958

CCA1
CCA tRNA nucleotidyltransferase, mitochondrial

1

0

High-throughput

0.458

High

797928

SDS24
Protein SDS24

1

0

High-throughput

0.458

High

865650

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.458

High

866142

JHD2
Histone demethylase JHD2

1

0

Small-scale

0.458

High

924678

NRK1
Nicotinamide riboside kinase

1

0

High-throughput

0.458

High

1023998

GPD1
Glycerol-3-phosphate dehydrogenase [NAD(+)] 1

1

0

High-throughput

0.458

High

1041923

HOT1
High-osmolarity-induced transcription protein 1

1

0

Small-scale

0.458

High

1053982

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

1059475

SWT1
Transcriptional protein SWT1

1

0

Small-scale

0.458

High

1035135

UBC7
Ubiquitin-conjugating enzyme E2 7

1

9

High-throughput

0.457

High

510855

HSP77
Import motor subunit, mitochondrial

1

15

High-throughput

0.445

High

527809

HSP72
Heat shock protein SSA2

1

14

High-throughput

0.445

High

546469

SSB1
Ribosome-associated molecular chaperone SSB1

1

15

High-throughput

0.445

High

554054

TCPA
T-complex protein 1 subunit alpha

1

10

High-throughput

0.445

High

742515

HSP7F
Heat shock protein homolog SSE1

1

17

High-throughput

0.445

High

752796

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.445

High

819930

SSB2
Ribosome-associated molecular chaperone SSB2

1

15

High-throughput

0.445

High

1043979

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

3

High-throughput

0.445

High

1059482

SET6
Potential protein lysine methyltransferase SET6

1

1

High-throughput

0.445

High

368198

THDH
Threonine dehydratase, mitochondrial

1

1

High-throughput

0.437

High

383919

RS17A
Small ribosomal subunit protein eS17A

1

4

High-throughput

0.437

High

503267

RS22A
Small ribosomal subunit protein uS8A

1

5

High-throughput

0.437

High

513248

RS8A
Small ribosomal subunit protein eS8A

1

5

High-throughput

0.437

High

633579

SAR1
Small COPII coat GTPase SAR1

1

10

High-throughput

0.437

High

753612

RS3A1
Small ribosomal subunit protein eS1A

1

7

High-throughput

0.437

High

779516

YKT6
Synaptobrevin homolog YKT6

1

1

High-throughput

0.437

High

812703

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

825484

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

3

High-throughput

0.437

High

926285

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

2

High-throughput

0.437

High

1059472

AP3D
AP-3 complex subunit delta

1

3

High-throughput

0.437

High

1050238

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.426

High

1059473

HFI1
SAGA complex subunit HFI1

1

0

High-throughput

0.426

High

671344

CANB
Calcineurin subunit B

1

0

High-throughput

0.249

Low

737591

ERG1
Squalene epoxidase ERG1

1

0

High-throughput

0.249

Low

796140

POA1
ADP-ribose 1''-phosphate phosphatase

1

0

High-throughput

0.249

Low

921493

COPZ
Coatomer subunit zeta

1

0

High-throughput

0.249

Low

924581

YNO0
Uncharacterized protein YNL140C

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025