HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: NUMA1 (Q14980)
Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)
Gene: NUMA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045618 - positive regulation of keratinocyte differentiation GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 369 Hs			1 2115
+	Hs
		1061275 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		555467 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		1061161 H2A2B_HUMAN (1-125): 5.78e-65: 204: 64.06		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		1061198 H2A1C_HUMAN (1-126): 5.97e-65: 204: 62.79		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		1061219 H2A1J_HUMAN (1-125): 5.25e-65: 204: 62.50		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		1061142 H2A2A_HUMAN (1-126): 8.18e-65: 203: 63.57		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		391707 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		594847 H2A1D_HUMAN (1-126): 1.88e-64: 203: 62.02		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		260775 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62
+	Hs
		260777 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		MYH11_HUMAN (1430-2076): 4.75e-22: 107: 8.41
+	Hs
		391578 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		MYH10_HUMAN (1281-2075): 5.26e-33: 142: 12.34
+	Hs
		1067434 H2A2A_HUMAN (1-126): 8.18e-65: 203: 63.57		EEA1_HUMAN (964-1838): 2.18e-28: 127: 12.15
+	Hs
		391713 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		EEA1_HUMAN (964-1838): 2.18e-28: 127: 12.15
+	Hs
		1067427 H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28		EEA1_HUMAN (964-1838): 2.18e-28: 127: 12.15
+	Hs
		728498 H2A1C_HUMAN (1-126): 5.97e-65: 204: 62.79		MYH11_HUMAN (1430-2076): 4.75e-22: 107: 8.41