HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: APLF (Q8IW19)
Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1)
Gene: APLF

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	26186194, 27067600, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0090734 - site of DNA damage GO:0160002 - ADP-D-ribose modification-dependent protein binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 369 Hs			1 511
+	Hs
		1218137 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		APLF_HUMAN (1-511): 0: 843: 100.00
+	Hs
		1216219 H2A2B_HUMAN (1-125): 5.78e-65: 204: 64.06		APLF_HUMAN (1-511): 0: 843: 100.00
+	Hs
		1151351 H2A2A_HUMAN (1-126): 8.18e-65: 203: 63.57		APLF_HUMAN (1-511): 0: 843: 100.00
+	Hs
		391779 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		APLF_HUMAN (1-511): 0: 843: 100.00
+	Hs
		470443 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		APLF_HUMAN (1-511): 0: 843: 100.00
+	Hs
		1087041 H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28		APLF_HUMAN (1-511): 0: 843: 100.00