HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24457600
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0001739 - sex chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0040029 - epigenetic regulation of gene expression
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 369 Hs			1 336
+	Hs
		260773 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		260986 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		BARD1_HUMAN (1-291): 1.2e-38: 147: 12.42
+	Hs
		260862 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		TRI26_HUMAN (36-282): 9.9e-36: 137: 17.90
+	Hs
		260784 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		1019374 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		TRI26_HUMAN (36-282): 9.9e-36: 137: 17.90
+	Hs
		555611 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		1216249 H2A2B_HUMAN (1-125): 5.78e-65: 204: 64.06		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		1185208 H2A3_HUMAN (1-126): 8.92e-65: 203: 62.79		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		391856 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		555425 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		391666 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		555627 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		391879 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		555322 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		391572 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		717932 H2A2A_HUMAN (1-126): 8.18e-65: 203: 63.57		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		555617 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		BARD1_HUMAN (1-291): 1.2e-38: 147: 12.42
+	Hs
		391861 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		BARD1_HUMAN (1-291): 1.2e-38: 147: 12.42
+	Hs
		555327 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		391581 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79