Protein: L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.2) (Duranin)

Gene: L2HDH, L2HGDH
Organism: Homo sapiens
Interactions: 56
UniProt ID: Q9H9P8

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006103 - 2-oxoglutarate metabolic process
GO:0016020 - membrane
GO:0044281 - small molecule metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

652412

TGM1
Protein-glutamine gamma-glutamyltransferase K

3

0

High-throughput

0.638

High

210784

KLK10
Kallikrein-10

3

3

High-throughput

0.609

High

457919

INVO
Involucrin

3

1

High-throughput

0.609

High

75727

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

3

1

High-throughput

0.585

High

683655

ITB8
Integrin beta-8

2

1

High-throughput

0.574

High

182778

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.536

High

777637

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

1

High-throughput

0.536

High

1310419

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

1437191

NPS3A
Protein NipSnap homolog 3A

1

1

High-throughput

0.536

High

1437192

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

2

High-throughput

0.536

High

1437193

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

521014

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

High-throughput

0.513

High

869242

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

1034822

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

1120504

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

1231469

ATLA3
Atlastin-3

1

0

High-throughput

0.513

High

1349120

F174A
Membrane protein FAM174A

1

0

High-throughput

0.513

High

1430255

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.513

High

69554

A2ML1
Alpha-2-macroglobulin-like protein 1

2

1

High-throughput

0.504

High

260959

RAMP3
Receptor activity-modifying protein 3

1

2

High-throughput

0.489

High

582623

PPAP
Prostatic acid phosphatase

1

1

High-throughput

0.489

High

1437194

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

242965

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

1033783

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

1114332

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1162559

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

2

High-throughput

0.479

High

1334937

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1367308

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

275108

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

766864

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

984284

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.458

High

1205149

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.458

High

831451

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

1115070

CUL4A
Cullin-4A

1

4

High-throughput

0.437

High

1255587

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

1433923

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

1437190

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.437

High

538807

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

0

High-throughput

0.426

High

261658

CATL2
Cathepsin L2

3

0

High-throughput

0.347

High

1009725

NGAL
Neutrophil gelatinase-associated lipocalin

3

0

High-throughput

0.347

High

190488

COPT1
High affinity copper uptake protein 1

2

0

High-throughput

0.313

High

302087

SEGN
Secretagogin

1

0

High-throughput

0.279

Low

502543

H2A1
Histone H2A type 1

1

0

High-throughput

0.279

Low

656024

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.279

Low

749399

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

874868

SPB4
Serpin B4

1

0

High-throughput

0.279

Low

1085955

HYAL1
Hyaluronidase-1

1

0

High-throughput

0.279

Low

1295036

TMM25
Transmembrane protein 25

1

0

High-throughput

0.279

Low

1415117

TBB2B
Tubulin beta-2B chain

1

0

High-throughput

0.279

Low

609334

SAP3
Ganglioside GM2 activator

1

0

High-throughput

0.249

Low

1178384

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1338379

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low

1397438

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1429349

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1429845

TOLIP
Toll-interacting protein

1

0

High-throughput

0.249

Low

1351532

HAVR2
Hepatitis A virus cellular receptor 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025