HitPredict

Interactor 1: FLNB (O75369)
Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)
Gene: FLNB

Interactor 2: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37071682
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~CH
Common GO terms	GO:0001725 - stress fiber GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2602 Hs			1 377
+	Hs
		261242 FLNB_HUMAN (1-2602): 0: 2855: 100.00		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Mm
		892189 FLNB_MOUSE (1-2602): 0: 2844: 95.85		ACTB_MOUSE (4-377): 0: 598: 94.12
+	Hs
		598031 FLNA_HUMAN (1-2602): 0: 2661: 69.59		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		598053 FLNA_HUMAN (1-2602): 0: 2661: 69.59		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		598055 FLNA_HUMAN (1-2602): 0: 2661: 69.59		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		598045 FLNA_HUMAN (1-2602): 0: 2661: 69.59		ACTA_HUMAN (1-377): 0: 596: 100.00
+	Hs
		891763 FLNC_HUMAN (6-2602): 0: 1470: 35.38		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		725637 ACTN2_HUMAN (5-364): 2.6e-116: 395: 26.61		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		891697 SPTB2_HUMAN (6-367): 4.86e-108: 389: 28.65		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		929824 SPTB2_HUMAN (6-367): 4.86e-108: 389: 28.65		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		932107 SPTB2_HUMAN (6-367): 4.86e-108: 389: 28.65		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		211548 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		211560 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		211561 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		ACTS_HUMAN (1-377): 0: 598: 97.88
+	Dm
		361167 ACTN_DROME (9-259): 5.05e-96: 336: 32.55		ACT4_DROME (1-377): 0: 647: 92.04
+	Hs
		506816 SPTB1_HUMAN (6-282): 2.13e-95: 347: 32.14		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Oc
		933099 Q07931_RABIT (5-265): 1.67e-105: 341: 34.34		ACTS_RABIT (1-377): 0: 598: 97.88
+	Hs
		892113 MACF1_HUMAN (16-239): 9.3e-35: 149: 40.69		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Dm
		284844 O77291_DROME (17-254): 3.17e-34: 147: 36.52		ACT1_DROME (1-377): 0: 597: 93.90