Protein: KLK7
Kallikrein-7 (hK7) (EC 3.4.21.117) (Serine protease 6) (Stratum corneum chymotryptic enzyme) (hSCCE)

Gene: KLK7
Organism: Homo sapiens
Interactions: 83
UniProt ID: P49862

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0002803 - positive regulation of antibacterial peptide production
GO:0004222 - metalloendopeptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

584495

VAV
Proto-oncogene vav

2

1

High-throughput

0.726

High

892146

PCOC2
Procollagen C-endopeptidase enhancer 2

1

14

High-throughput

0.691

High

421732

A4
Amyloid-beta precursor protein

1

13

High-throughput

0.647

High

391589

FRIH
Ferritin heavy chain

2

3

High-throughput

0.628

High

892109

LRC10
Leucine-rich repeat-containing protein 10

1

1

High-throughput

0.618

High

892137

ISK5
Serine protease inhibitor Kazal-type 5

1

9

Small-scale

0.618

High

892103

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

3

1

High-throughput

0.609

High

892131

GMCL1
Germ cell-less protein-like 1

3

4

High-throughput

0.609

High

338684

VNN2
Pantetheine hydrolase VNN2

2

0

High-throughput

0.602

High

892120

UBAC2
Ubiquitin-associated domain-containing protein 2

2

0

High-throughput

0.585

High

892132

CDK15
Cyclin-dependent kinase 15

2

1

High-throughput

0.574

High

892140

TB22B
TBC1 domain family member 22B

2

3

High-throughput

0.574

High

892149

FCF1
rRNA-processing protein FCF1 homolog

2

1

High-throughput

0.574

High

376761

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

8

High-throughput

0.541

High

722774

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

4

High-throughput

0.536

High

892098

UBE3A
Ubiquitin-protein ligase E3A

1

3

High-throughput

0.536

High

892138

TSSP
Thymus-specific serine protease

1

2

High-throughput

0.536

High

351671

SG1D1
Secretoglobin family 1D member 1

1

0

High-throughput

0.513

High

420248

IFNA4
Interferon alpha-4

1

0

High-throughput

0.513

High

892133

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.513

High

336642

BAG4
BAG family molecular chaperone regulator 4

1

3

High-throughput

0.494

High

354926

CHK2
Serine/threonine-protein kinase Chk2

1

3

High-throughput

0.494

High

611035

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

9

High-throughput

0.494

High

624486

WT1
Wilms tumor protein

1

2

High-throughput

0.494

High

664682

CCND1
G1/S-specific cyclin-D1

1

2

High-throughput

0.494

High

892100

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

10

High-throughput

0.494

High

892105

STK11
Serine/threonine-protein kinase STK11

1

2

High-throughput

0.494

High

219803

CHSTA
Carbohydrate sulfotransferase 10

1

3

High-throughput

0.489

High

282687

E2F6
Transcription factor E2F6

1

1

High-throughput

0.489

High

292585

RENR
Renin receptor

1

2

High-throughput

0.489

High

318462

TOX4
TOX high mobility group box family member 4

1

4

High-throughput

0.489

High

552169

ADT3
ADP/ATP translocase 3

1

13

High-throughput

0.489

High

639208

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

1

High-throughput

0.489

High

666813

CCNC
Cyclin-C

1

1

High-throughput

0.489

High

733308

CCR1
C-C chemokine receptor type 1

1

6

High-throughput

0.489

High

876296

PTSS1
Phosphatidylserine synthase 1

1

1

High-throughput

0.489

High

892097

STX17
Syntaxin-17

1

4

High-throughput

0.489

High

892099

GABPA
GA-binding protein alpha chain

1

4

High-throughput

0.489

High

892107

CR021
UPF0711 protein C18orf21

1

2

High-throughput

0.489

High

892113

ZC3C1
Zinc finger C3HC-type protein 1

1

1

High-throughput

0.489

High

892118

UB2J2
Ubiquitin-conjugating enzyme E2 J2

1

4

High-throughput

0.489

High

892121

EHBP1
EH domain-binding protein 1

1

3

High-throughput

0.489

High

892123

TRI41
E3 ubiquitin-protein ligase TRIM41

1

2

High-throughput

0.489

High

892124

ZDH19
Palmitoyltransferase ZDHHC19

1

2

High-throughput

0.489

High

892125

SIA8A
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

1

5

High-throughput

0.489

High

892126

PIGT
GPI-anchor transamidase component PIGT

1

3

High-throughput

0.489

High

892127

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

5

High-throughput

0.489

High

892134

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

6

High-throughput

0.489

High

892136

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

12

High-throughput

0.489

High

892139

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.489

High

892141

KLH11
Kelch-like protein 11

1

2

High-throughput

0.489

High

892143

DTL
Denticleless protein homolog

1

1

High-throughput

0.489

High

892145

PHF11
PHD finger protein 11

1

3

High-throughput

0.489

High

892147

PHF8
Histone lysine demethylase PHF8

1

1

High-throughput

0.489

High

892148

SSUH2
Protein SSUH2 homolog

1

4

High-throughput

0.489

High

892104

CDSN
Corneodesmosin

1

0

Small-scale

0.480

High

458676

SAP
Prosaposin

1

1

Small-scale

0.445

High

892096

CAMP
Cathelicidin antimicrobial peptide

1

2

Small-scale

0.445

High

892108

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

5

High-throughput

0.437

High

892135

FACD2
Fanconi anemia group D2 protein

1

5

High-throughput

0.437

High

892142

PLK2
Serine/threonine-protein kinase PLK2

1

2

High-throughput

0.437

High

219613

B2L11
Bcl-2-like protein 11

1

1

High-throughput

0.407

High

261130

NSMA
Sphingomyelin phosphodiesterase 2

1

5

High-throughput

0.407

High

839441

PI4KA
Phosphatidylinositol 4-kinase alpha

1

5

High-throughput

0.407

High

892110

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.407

High

892119

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

5

High-throughput

0.407

High

764224

CAH8
Carbonic anhydrase-related protein

3

0

High-throughput

0.347

High

892116

PLCZ1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

3

0

High-throughput

0.347

High

720091

PURA2
Adenylosuccinate synthetase isozyme 2

1

0

High-throughput

0.279

Low

892101

ZN154
Zinc finger protein 154

1

0

High-throughput

0.279

Low

892102

MTAP
S-methyl-5'-thioadenosine phosphorylase

1

0

High-throughput

0.279

Low

892106

ZIC1
Zinc finger protein ZIC 1

1

0

High-throughput

0.279

Low

892114

AROS
Active regulator of SIRT1

1

0

High-throughput

0.279

Low

892115

SFR1
Swi5-dependent recombination DNA repair protein 1 homolog

1

0

High-throughput

0.279

Low

892117

EPHX4
Epoxide hydrolase 4

1

0

High-throughput

0.279

Low

892122

MYBPP
MYCBP-associated protein

1

0

High-throughput

0.279

Low

892128

TOM6
Mitochondrial import receptor subunit TOM6 homolog

1

0

High-throughput

0.279

Low

892130

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.279

Low

892144

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

1

0

High-throughput

0.279

Low

105580

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

892111

CNKR3
Connector enhancer of kinase suppressor of ras 3

1

0

High-throughput

0.232

Low

892112

DEFI8
Differentially expressed in FDCP 8 homolog

1

0

High-throughput

0.232

Low

892129

MRAP2
Melanocortin-2 receptor accessory protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025