Protein: KLK5
Kallikrein-5 (EC 3.4.21.-) (Kallikrein-like protein 2) (KLK-L2) (Stratum corneum tryptic enzyme)

Gene: KLK5
Organism: Homo sapiens
Interactions: 134
UniProt ID: Q9Y337

Gene Ontology (top 5):
GO:0002803 - positive regulation of antibacterial peptide production
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1491052

LOXL2
Lysyl oxidase homolog 2

4

4

High-throughput

0.892

High

287633

LRP6
Low-density lipoprotein receptor-related protein 6

2

12

High-throughput

0.811

High

1446737

ISK5
Serine protease inhibitor Kazal-type 5

2

7

Small-scale

0.754

High

1439460

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

2

10

High-throughput

0.705

High

1047787

NOTC2
Neurogenic locus notch homolog protein 2

1

17

High-throughput

0.698

High

1160936

PRSS8
Prostasin

1

8

High-throughput

0.691

High

718919

CCND3
G1/S-specific cyclin-D3

3

2

High-throughput

0.667

High

997200

TBA4A
Tubulin alpha-4A chain

3

14

High-throughput

0.667

High

1259592

TBA1A
Tubulin alpha-1A chain

3

15

High-throughput

0.667

High

1329651

EFNMT
eEF1A lysine and N-terminal methyltransferase

3

1

High-throughput

0.667

High

1401339

PASK
PAS domain-containing serine/threonine-protein kinase

3

4

High-throughput

0.667

High

539931

ARY2
Arylamine N-acetyltransferase 2

3

0

High-throughput

0.638

High

943878

CF298
Cilia- and flagella-associated protein 298

3

0

High-throughput

0.638

High

62223

DEN11
DENN domain-containing protein 11

4

2

High-throughput

0.630

High

239899

PCDH7
Protocadherin-7

4

16

High-throughput

0.630

High

1294399

FRAS1
Extracellular matrix organizing protein FRAS1

4

20

High-throughput

0.630

High

391677

FRIH
Ferritin heavy chain

2

3

High-throughput

0.628

High

582366

ARSA
Arylsulfatase A

2

9

High-throughput

0.628

High

274933

LRP5
Low-density lipoprotein receptor-related protein 5

1

11

High-throughput

0.618

High

376566

LDLR
Low-density lipoprotein receptor

1

12

High-throughput

0.618

High

1144688

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

8

High-throughput

0.618

High

1384397

SO4A1
Solute carrier organic anion transporter family member 4A1

1

2

High-throughput

0.618

High

408195

TBB4A
Tubulin beta-4A chain

2

13

High-throughput

0.611

High

397629

NU1M
NADH-ubiquinone oxidoreductase chain 1

3

1

High-throughput

0.609

High

612129

ITB5
Integrin beta-5

3

5

High-throughput

0.609

High

940512

DPOE2
DNA polymerase epsilon subunit 2

3

1

High-throughput

0.609

High

1108766

TBB3
Tubulin beta-3 chain

3

13

High-throughput

0.609

High

1192015

TBB8
Tubulin beta-8 chain

3

13

High-throughput

0.609

High

1411862

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

3

6

High-throughput

0.609

High

1491056

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

3

1

High-throughput

0.609

High

1364947

AP3S1
AP-3 complex subunit sigma-1

3

2

High-throughput

0.593

High

1322271

FCSK
L-fucose kinase

2

0

High-throughput

0.585

High

1407526

CPNE1
Copine-1

2

0

High-throughput

0.585

High

1451938

MKS1
Tectonic-like complex member MKS1

2

0

High-throughput

0.585

High

772352

FBN2
Fibrillin-2 [Cleaved into: Placensin]

1

17

High-throughput

0.575

High

1127617

FAT1
Protocadherin Fat 1

1

10

High-throughput

0.575

High

1338555

PRS33
Serine protease 33

1

9

High-throughput

0.575

High

1105595

OS9
Protein OS-9

2

3

High-throughput

0.558

High

1212707

GT253
Inactive glycosyltransferase 25 family member 3

2

2

High-throughput

0.558

High

1460568

MCM8
DNA helicase MCM8

2

1

High-throughput

0.558

High

1462673

NEUR3
Sialidase-3

2

2

High-throughput

0.558

High

1307368

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

2

6

High-throughput

0.549

High

170446

AURKA
Aurora kinase A

1

1

High-throughput

0.541

High

336807

BAG4
BAG family molecular chaperone regulator 4

1

3

High-throughput

0.541

High

376934

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

9

High-throughput

0.541

High

397280

ESR1
Estrogen receptor

1

7

High-throughput

0.541

High

411132

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

14

High-throughput

0.541

High

1132470

CASP8
Caspase-8

1

5

High-throughput

0.541

High

1407503

TS101
Tumor susceptibility gene 101 protein

1

1

High-throughput

0.541

High

322773

RHBT3
Rho-related BTB domain-containing protein 3

1

6

High-throughput

0.536

High

335717

MOCS3
Adenylyltransferase and sulfurtransferase MOCS3

1

2

High-throughput

0.536

High

370023

TIMP1
Metalloproteinase inhibitor 1

1

2

High-throughput

0.536

High

457792

TBB5
Tubulin beta chain

1

13

High-throughput

0.536

High

535699

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.536

High

722823

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

4

High-throughput

0.536

High

760806

BMP8B
Bone morphogenetic protein 8B

1

9

High-throughput

0.536

High

858737

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

6

High-throughput

0.536

High

997574

TBB4B
Tubulin beta-4B chain

1

13

High-throughput

0.536

High

1112276

PEX6
Peroxisomal ATPase PEX6

1

1

High-throughput

0.536

High

1143825

PON2
Serum paraoxonase/arylesterase 2

1

4

High-throughput

0.536

High

1394118

SYNM
Asparaginyl-tRNA synthetase

1

2

High-throughput

0.536

High

1447067

TSSP
Thymus-specific serine protease

1

2

High-throughput

0.536

High

1460872

FBX2
F-box only protein 2

1

2

High-throughput

0.536

High

1336113

KREM2
Kremen protein 2

1

20

High-throughput

0.514

High

1025867

BORG5
Cdc42 effector protein 1

1

0

High-throughput

0.513

High

1291409

TRXR3
Thioredoxin reductase 3

1

0

High-throughput

0.513

High

1371170

CLP1
Polyribonucleotide 5'-hydroxyl-kinase Clp1

1

0

High-throughput

0.513

High

1400450

TPPC9
Trafficking protein particle complex subunit 9

1

0

High-throughput

0.513

High

465698

IGF1R
Insulin-like growth factor 1 receptor

1

15

High-throughput

0.494

High

565747

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

6

High-throughput

0.489

High

882963

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.489

High

1105884

TMED1
Transmembrane emp24 domain-containing protein 1

1

4

High-throughput

0.489

High

1118643

TBB2A
Tubulin beta-2A chain

1

13

High-throughput

0.489

High

1193220

OFUT4
GDP-fucose protein O-fucosyltransferase 4

1

2

High-throughput

0.489

High

1207025

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

6

High-throughput

0.489

High

1218876

GP107
Protein GPR107

1

3

High-throughput

0.489

High

1233678

DRS7B
Dehydrogenase/reductase SDR family member 7B

1

8

High-throughput

0.489

High

1235755

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

15

High-throughput

0.489

High

1242109

TTC27
Tetratricopeptide repeat protein 27

1

5

High-throughput

0.489

High

1245628

TXD11
Thioredoxin domain-containing protein 11

1

8

High-throughput

0.489

High

1288110

OAF
Out at first protein homolog

1

1

High-throughput

0.489

High

1312309

MIRO2
Mitochondrial Rho GTPase 2

1

8

High-throughput

0.489

High

1312342

MIRO1
Mitochondrial Rho GTPase 1

1

8

High-throughput

0.489

High

1358796

ZDH19
Palmitoyltransferase ZDHHC19

1

2

High-throughput

0.489

High

1364124

TM9S4
Transmembrane 9 superfamily member 4

1

8

High-throughput

0.489

High

1388127

ERLEC
Endoplasmic reticulum lectin 1

1

3

High-throughput

0.489

High

1400845

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.489

High

1410641

TBA1C
Tubulin alpha-1C chain

1

15

High-throughput

0.489

High

1410980

CSTN3
Calsyntenin-3

1

20

High-throughput

0.489

High

1414220

TBB6
Tubulin beta-6 chain

1

13

High-throughput

0.489

High

1417455

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

1

High-throughput

0.489

High

1458786

SE1L1
Protein sel-1 homolog 1

1

7

High-throughput

0.489

High

1461346

SARDH
Sarcosine dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

1462048

DD19B
ATP-dependent RNA helicase DDX19B

1

3

High-throughput

0.489

High

547225

PYC
Pyruvate carboxylase, mitochondrial

1

2

High-throughput

0.479

High

1311543

BBS7
BBSome complex member BBS7

1

0

High-throughput

0.458

High

1322495

TTC5
Tetratricopeptide repeat protein 5

1

0

High-throughput

0.458

High

219667

B2L11
Bcl-2-like protein 11

1

1

High-throughput

0.445

High

635651

FILA
Filaggrin

1

9

Small-scale

0.445

High

839524

PI4KA
Phosphatidylinositol 4-kinase alpha

1

5

High-throughput

0.445

High

892434

CAMP
Cathelicidin antimicrobial peptide

1

2

Small-scale

0.445

High

1323808

ARG28
Rho guanine nucleotide exchange factor 28

1

2

High-throughput

0.445

High

1195717

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

5

High-throughput

0.437

High

1211504

FREM2
FRAS1-related extracellular matrix protein 2

1

13

High-throughput

0.437

High

1292523

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

4

High-throughput

0.437

High

1413877

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.426

High

1430863

SIL1
Nucleotide exchange factor SIL1

1

0

High-throughput

0.426

High

1491055

TIM8B
Mitochondrial import inner membrane translocase subunit Tim8 B

1

0

High-throughput

0.426

High

261325

NSMA
Sphingomyelin phosphodiesterase 2

1

5

High-throughput

0.407

High

592709

ITB4
Integrin beta-4

1

7

High-throughput

0.407

High

848454

MAGA6
Melanoma-associated antigen 6

1

3

High-throughput

0.407

High

1196357

ZNG1F
Zinc-regulated GTPase metalloprotein activator 1F

1

6

High-throughput

0.407

High

1250386

PCD23
Protocadherin-23

1

12

High-throughput

0.407

High

1252849

NFXL1
NF-X1-type zinc finger protein NFXL1

1

16

High-throughput

0.407

High

1331173

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

5

High-throughput

0.407

High

1395507

PCD16
Protocadherin-16

1

15

High-throughput

0.407

High

1404075

MYCBP
c-Myc-binding protein

1

2

High-throughput

0.407

High

1458803

PEF1
Peflin

1

2

High-throughput

0.407

High

1462164

PCDGK
Protocadherin gamma-C3

1

5

High-throughput

0.407

High

1462179

PCDGG
Protocadherin gamma-B4

1

6

High-throughput

0.407

High

1491051

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

4

High-throughput

0.407

High

1491053

PCDBB
Protocadherin beta-11

1

4

High-throughput

0.407

High

1491054

PCDA8
Protocadherin alpha-8

1

6

High-throughput

0.407

High

1383756

EME1
Structure-specific endonuclease subunit EME1

3

0

High-throughput

0.347

High

1315224

TRM44
Probable tRNA

2

0

High-throughput

0.318

High

1447078

MANBL
Protein MANBAL

2

0

High-throughput

0.316

High

1389321

T3HPD
Trans-3-hydroxy-L-proline dehydratase

2

0

High-throughput

0.313

High

636036

PRPS3
Ribose-phosphate pyrophosphokinase 3

1

0

High-throughput

0.279

Low

1235431

ACD10
Acyl-CoA dehydrogenase family member 10

1

0

High-throughput

0.279

Low

1347977

NUBPL
Iron-sulfur cluster transfer protein NUBPL

1

0

High-throughput

0.279

Low

1450546

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.279

Low

1460523

GGT7
Glutathione hydrolase 7

1

0

High-throughput

0.279

Low

1403184

INT14
Integrator complex subunit 14

1

0

High-throughput

0.249

Low

1326758

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025