HitPredict

Interactor 1: NCOR1 (O75376)
Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)
Gene: NCOR1

Interactor 2: THB (P10828)
Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)
Gene: THRB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.752

Property	Details
Experiments	11903058, 19211732, 15336696, 14985366, 9121466, 25572392, 17242407, 7566114, 20956942
Identification Methods	pull down, two hybrid, far western blotting, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2440 Hs			1 461
+	Hs
		261399 NCOR1_HUMAN (1-2440): 0: 780: 100.00		RXRA_HUMAN (19-460): 4.47e-117: 352: 22.49
+	Hs
		261369 NCOR1_HUMAN (1-2440): 0: 780: 100.00		ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66
+	Hs
		261474 NCOR1_HUMAN (1-2440): 0: 780: 100.00		PPARD_HUMAN (87-461): 8.06e-112: 338: 28.46
+	Hs
		261381 NCOR1_HUMAN (1-2440): 0: 780: 100.00		RARA_HUMAN (30-461): 2.47e-111: 337: 30.46
+	Hs
		261450 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR1H2_HUMAN (9-460): 1.14e-110: 336: 25.48
+	Hs
		261493 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR1H3_HUMAN (11-460): 4.58e-110: 334: 26.97
+	Hs
		261382 NCOR1_HUMAN (1-2440): 0: 780: 100.00		THA_HUMAN (88-430): 1.49e-108: 331: 79.59
+	Hs
		261429 NCOR1_HUMAN (1-2440): 0: 780: 100.00		HNF4A_HUMAN (59-459): 1.3e-107: 329: 24.63
+	Hs
		261390 NCOR1_HUMAN (1-2440): 0: 780: 100.00		RARG_HUMAN (31-461): 3.61e-107: 327: 30.51
+	Hs
		261424 NCOR1_HUMAN (1-2440): 0: 780: 100.00		PPARG_HUMAN (28-461): 2.21e-100: 311: 24.33
+	Hs
		261481 NCOR1_HUMAN (1-2440): 0: 780: 100.00		PPARA_HUMAN (64-461): 1.91e-97: 302: 25.00
+	Hs
		261568 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR1H4_HUMAN (37-460): 1.25e-96: 300: 28.60
+	Mm
		723171 NCOR1_MOUSE (1-2440): 0: 701: 89.79		PPARD_MOUSE (76-461): 5.43e-97: 300: 26.68
+	Hs
		261355 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR1I2_HUMAN (105-459): 5.25e-43: 159: 29.18
+	Xl
		574911 NCOR1_XENLA (1-2440): 1.54e-154: 538: 62.28		THBA_XENLA (89-461): 5.46e-126: 372: 92.76
+	Xl
		546251 NCOR1_XENLA (1-2440): 1.54e-154: 538: 62.28		THAA_XENLA (79-461): 7.7e-120: 358: 81.20
+	Hs
		370824 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66
+	Hs
		488042 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		RARA_HUMAN (30-461): 2.47e-111: 337: 30.46
+	Mm
		193216 NCOR2_MOUSE (1-2439): 3.58e-138: 486: 34.08		NR1I3_MOUSE (107-436): 2.1e-40: 150: 30.15
+	Hs
		265885 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		NR1I2_HUMAN (105-459): 5.25e-43: 159: 29.18