HitPredict

Interactor 1: VAMP4 (O75379)
Vesicle-associated membrane protein 4 (VAMP-4)
Gene: VAMP4

Interactor 2: VTI1B (Q9UEU0)
Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1)
Gene: VTI1B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	28514442, 11839770, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Synaptobrevin~V-SNARE_C
Common GO terms	GO:0005794 - Golgi apparatus GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 141 Hs			1 232
+	Mm
		291513 VAMP7_MOUSE (15-139): 2.4e-33: 118: 28.00		VTI1B_MOUSE (1-232): 4.49e-61: 193: 92.24
+	Hs
		261703 VAMP4_HUMAN (1-120): 4.03e-40: 132: 100.00		VTI1A_HUMAN (7-231): 7.83e-55: 176: 27.56
+	At
		1276255 VA721_ARATH (10-140): 2.62e-41: 138: 31.30		NPS11_ARATH (1-214): 9.22e-51: 167: 16.67
+	At
		812696 VA722_ARATH (10-139): 9.81e-40: 134: 33.08		NPS11_ARATH (1-214): 9.22e-51: 167: 16.67
+	Hs
		850604 VAMP7_HUMAN (15-139): 2.43e-33: 118: 27.20		VTI1B_HUMAN (1-232): 7.05e-54: 174: 100.00
+	At
		221565 VA711_ARATH (7-138): 8.21e-36: 124: 23.49		VTI11_ARATH (7-230): 1.24e-49: 163: 26.22
+	Dm
		1178140 Q7JYX5_DROME (15-138): 4.76e-36: 125: 27.42		Q9W0N6_DROME (9-228): 1.19e-48: 161: 22.27
+	Hs
		151535 VAMP4_HUMAN (1-120): 4.03e-40: 132: 100.00		GOSR2_HUMAN (11-226): 4.43e-45: 151: 15.07
+	Rn
		1144366 VAMP1_RAT (32-125): 5.09e-29: 103: 31.92		VTI1A_RAT (7-232): 5.27e-56: 179: 27.88
+	Dm
		1178131 Q7JYX5_DROME (15-138): 4.76e-36: 125: 27.42		GOSR2_DROME (11-226): 3.82e-47: 156: 17.13
+	Dm
		577264 SYB_DROME (24-135): 9.5e-32: 112: 26.79		Q9W0N6_DROME (9-228): 1.19e-48: 161: 22.27
+	Hs
		1079397 VAMP3_HUMAN (47-119): 2.22e-26: 96.7: 41.10		VTI1A_HUMAN (7-231): 7.83e-55: 176: 27.56
+	Hs
		1079465 VAMP3_HUMAN (47-119): 2.22e-26: 96.7: 41.10		VTI1B_HUMAN (1-232): 7.05e-54: 174: 100.00
+	Hs
		1284295 VAMP8_HUMAN (41-120): 1.87e-25: 94.3: 27.50		VTI1A_HUMAN (7-231): 7.83e-55: 176: 27.56
+	Hs
		1313462 VAMP8_HUMAN (41-120): 1.87e-25: 94.3: 27.50		VTI1B_HUMAN (1-232): 7.05e-54: 174: 100.00
+	Dm
		577252 SYB_DROME (24-135): 9.5e-32: 112: 26.79		GOSR2_DROME (11-226): 3.82e-47: 156: 17.13
+	Hs
		151537 VAMP5_HUMAN (52-118): 5.78e-18: 75.8: 31.34		GOSR2_HUMAN (11-226): 4.43e-45: 151: 15.07
+	Sc
		979398 NYV1_YEAST (11-136): 5.27e-27: 102: 25.00		VTI1_YEAST (7-210): 3.79e-32: 118: 22.33
+	Sc
		605872 SEC22_YEAST (23-133): 3.08e-25: 97: 17.12		VTI1_YEAST (7-210): 3.79e-32: 118: 22.33
+	Sc
		704536 SNC2_YEAST (42-120): 1.73e-25: 95.1: 30.38		VTI1_YEAST (7-210): 3.79e-32: 118: 22.33